Design and Analysis of Fluid Pressure in Microchannel for Healthcare Application

Year : 2025 | Volume : 13 | Special Issue 06 | Page : 553 565
    By

    Ankur Saxena,

  • Mahesh Kumar,

  • Bhagwat Kakde,

  • Chandrmani Yadav,

  • Mukesh Tiwari,

  1. Assistant Professor, Department of Electronics and Communication Engineering, Bharat Institute of Engineering and Technology, Hyderabad, Telangana, India
  2. Assistant Professor, Department of Information and Communication Technology Pandit Deendayal Energy University, Gandhinagar, Gujarat, India
  3. Associate Professor, Department of Electronics & Telecommunication Engineering, Sandip Institute of Technology and Research Centre, Nashik, Maharshtra, India
  4. Assistant Professor, Department of Mechanical Engineering, Marwadi University Research Center, Faculty of Engineering & Technology, Marwadi University, Rajkot, Gujarat,
  5. Assistant Professor, Department of Electronics & Telecommunication Engineering, Padmabhooshan Vasantdada Patil Institute of Technology, Bavdhan, Pune, Maharshtra, India

Abstract

The research article study explores an innovative approach for optimizing fluid pressure within microchannels using 2D integrated microcantilevers. These microcantilevers, strategically placed within the microchannel, serve as sensitive sensors to monitor fluid pressure variations. The computational simulations illustrate the effective approach to achieving improved pressure measurement for cell separation outcomes. The integrated microcantilever can determine the fluid pressure inside the microchannel, and also determine the pressure required for the cell separation in the microchannel through the microcantilever deflection. The novelty of this research is to reduce the setup size of the device for the measurement of fluid pressure in the microchannel and the ability to control the cell pressure in the microchannel for the separation of cells. The research article designed an integrated microcantilever (R-cantilever, T-cantilever, Pi-cantilever) within microchannel maximum pressure and deflection. In the study, the T-microcantilever exhibited a maximum deflection of 5.32 µm, while the Pi-microcantilever reached a maximum pressure value of 4.66 Pa for the fluid water. The R-cantilever is an integrated microchannel for measurement of the pressure of fluid inside the microchannel where the cell separation takes place. The maximum pressure optimized is 9.17 Pa where get maximum deflection is 5.1 µm of R-cantilever. The design and simulation of the integrated microcantilever structures for the microfluidic pressure sensing mechanism were conducted using the Finite Element Method (FEM) tool for biological cell separation application.

Keywords: Microcantilever, Pressure, Microchannel, Microfluidic, Cell Separation, Finite element method.

[This article belongs to Special Issue under section in Journal of Polymer and Composites (jopc)]

How to cite this article:
Ankur Saxena, Mahesh Kumar, Bhagwat Kakde, Chandrmani Yadav, Mukesh Tiwari. Design and Analysis of Fluid Pressure in Microchannel for Healthcare Application. Journal of Polymer and Composites. 2025; 13(06):553-565.
How to cite this URL:
Ankur Saxena, Mahesh Kumar, Bhagwat Kakde, Chandrmani Yadav, Mukesh Tiwari. Design and Analysis of Fluid Pressure in Microchannel for Healthcare Application. Journal of Polymer and Composites. 2025; 13(06):553-565. Available from: https://journals.stmjournals.com/jopc/article=2025/view=227318


References

  1. Daridon A, Sequeira M, Pennarun-Thomas G, Dirac H, Krog JP, Gravesen P, et al. Chemical sensing using an integrated microfluidic system based on the Berthelot reaction. Sens Actuators B Chem. 2001;76(1–3):235–43.
  2. Srivastava N, Burns MA. Microfluidic pressure sensing using trapped air compression. Lab Chip. 2007;7(5):633–7.
  3. Iliescu C, Poenar DP, Carp M, Loe FC. A microfluidic device for impedance spectroscopy analysis of biological samples. Sens Actuators B Chem. 2007;123(1):168–76.
  4. Blanco FJ, Agirregabiria M, Berganzo J, Mayora K, Elizalde J, Calle A, et al. Microfluidic-optical integrated CMOS compatible devices for label-free biochemical sensing. J Micromech Microeng. 2006;16(5):1006.
  5. Shi Q, Wang H, Wang T, Lee C. Self-powered liquid triboelectric microfluidic sensor for pressure sensing and finger motion monitoring applications. Nano Energy. 2016;30:450–9.
  6. Kumar M, Kumar A, George SD, Singh K. A novel microfluidic device with tapered sidewall electrodes for efficient ternary blood cells (WBCs, RBCs and PLTs) separation. Meas Sci Technol. 2021;32(11):115106.
  7. Zhang Q, Lei J, Chen Y, Wu Y, Xiao H. Glass 3D printing of microfluidic pressure sensor interrogated by fiber-optic refractometry. IEEE Photon Technol Lett. 2020;32(7):414–7.
  8. Kumar M, Palekar N, Kumar A, Shrivastava A, Singh K. Influence of interdigitated electrode-gap width ratio on efficient separation trajectories of blood cells in a microfluidic device. In: 2021 International Conference on Advance Computing and Innovative Technologies in Engineering (ICACITE). IEEE; 2021. p. 1045–8.
  9. Zhou X, Zhang R, Li L, Zhang L, Liu B, Deng Z, et al. A liquid metal based capacitive soft pressure microsensor. Lab Chip. 2019;19(5):807–14.
  10. Oh JH, Woo JY, Jo S, Han CS. Pressure-conductive rubber sensor based on liquid-metal-PDMS composite. Sens Actuators A Phys. 2019;299:111610.
  11. Zhou Y, Werner EM, Lee E, Chu M, Nguyen T, Costa KD, et al. High-resolution integrated piezoresistive sensors for microfluidic monitoring. Lab Chip. 2021;21(1):83–92.
  12. Yoon SG, Chang ST. Microfluidic capacitive sensors with ionic liquid electrodes and CNT/PDMS nanocomposites for simultaneous sensing of pressure and temperature. J Mater Chem C. 2017;5(8):1910–9.
  13. Lien V, Vollmer F. Microfluidic flow rate detection based on integrated optical fiber cantilever. Lab Chip. 2007;7(10):1352–6.
  14. Kumar M, Palekar N, Kumar A, Sharma NN, Akhtar J, Singh K. Levitation of red blood cells in microchannel for microfluidic MEMS healthcare device application. Mater Today Proc. 2021.
  15. Nag M, Kumar A, Singh K, Pratap B. Graphene based flexible piezoresistive pressure sensor for electric vehicles applications. In: AIP Conf Proc. 2020;2294(1):020009.
  16. Hoera C, Kiontke A, Pahl M, Belder D. A chip-integrated optical microfluidic pressure sensor. Sens Actuators B Chem. 2018;255:2407–15.
  17. Hirayama K, Tsukagoshi T, Thanh-Vinh N, Ichikawa Y, Shimoyama I. Piezoresistive cantilever integrated microfluidic channel for measuring cellular properties. In: 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE; 2016. p. 698–700.
  18. Jung T, Yang S. Highly stable liquid metal-based pressure sensor integrated with a microfluidic channel. Sensors. 2015;15(5):11823–35.
  19. Saxena A, Agrawal VK. Comparative study of cantilever RF MEMS switch. Mater Today Proc. 2017;4(9):10328–31.
  20. Noeth N, Keller SS, Boisen A. Integrated cantilever-based flow sensors with tunable sensitivity for in-line monitoring of flow fluctuations in microfluidic systems. Sensors. 2014;14(1):229–44.
  21. Bungartz HJ, Schäfer M, editors. Fluid-structure interaction: modelling, simulation, optimization. Vol. 53. Springer; 2006.
  22. Rao KS, Sravani KG, Yugandhar G, Rao GV, Mani VN. Design and analysis of fluid structure interaction in a horizontal micro channel. Procedia Mater Sci. 2015;10:768–88.
  23. Tezduyar TE. Stabilized finite element methods for computation of flows with moving boundaries and interfaces. In: Lecture Notes on Finite Element Simulation of Flow Problems (Basic-Advanced Course). Tokyo: Japan Society of Computational Engineering and Sciences; 2003.
  24. Saxena A, Kumar M, Gupta A, Shrivastava A, Singh K. Optimization of microfluidic pressure sensing mechanism integrated microcantilever in microchannel. In: 2021 International Conference on Recent Trends on Electronics, Information, Communication & Technology (RTEICT). IEEE; 2021. p. 361–5.
  25. Arya S, Sharma V, Shimi SL. Design and fabrication of micro-channels-based fluid viscosity sensor. ISSS J Micro Smart Syst. 2017;6(2):119–25.
  26. Hao PF, He F, Zhu KQ. Flow characteristics in a trapezoidal silicon microchannel. J Micromech Microeng. 2005;15(6):1362.
  27. Burger J, Haldenwang R, Alderman N. Friction factor-Reynolds number relationship for laminar flow of non-Newtonian fluids in open channels of different cross-sectional shapes. Chem Eng Sci. 2010;65(11):3549–56.
  28. Saxena A, Kumar M, Mishra D, Singh K. An efficient microfluidic pressure sensing structure optimization using microcantilever integration. Phys Scr. 2023;98(5):055006.31. Saxena A, Kumar M, Singh K. Analytical study of 2D integrated microcantilever pressure sensing of fluid for healthcare application. J Mines Met Fuels. 2023;71(4).
  29. Saxena A, Kumar M, Singh K. Analytical study of 2D integrated microcantilever pressure sensing of fluid for healthcare application. J Mines Met Fuels. 2023;71(4).
  30. Singh K, Akhtar S, Varghese S, Akhtar J. Design and development of MEMS pressure sensor characterization setup with low interfacing noise by using NI-PXI system. In: Physics of Semiconductor Devices. Springer, Cham; 2014. p. 449–51.
  31. Kamat AM, Zheng X, Jayawardhana B, Kottapalli AGP. Bioinspired PDMS-graphene cantilever flow sensors using 3D printing and replica moulding. Nanotechnology. 2021;32(9):095501.
  32. Zhou X, Zhang R, Li L, Zhang L, Liu B, Deng Z, et al. A liquid metal based capacitive soft pressure microsensor. Lab Chip. 2019;19(5):807–14.
  33. Saxena A, Kumar M, Mishra D, Singh K. Optimization of Newtonian fluid pressure in microcantilever integrated flexible microfluidic channel for healthcare application. Biomed Phys Eng Express. 2024;10(3):035015.
  34. Kumar M, Palekar N, Saxena A, Kumar A, Singh K. Optimization of electrode excitation in a microfluidic bio-cell sorter with trapezoidal electrodes for blood cell separation. Mater Today Proc. 2023; 74:274–80.
  35. Kumar M, Gupta A, Mishra A, Saxena A, Kumar A, Singh K. Electrode optimization for improved dielectrophoretic separation of microparticles. In: AIP Conf Proc. 2023;2752(1).

Special Issue Subscription Original Research
Volume 13
Special Issue 06
Received 10/06/2025
Accepted 03/07/2025
Published 17/09/2025
Publication Time 99 Days


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