Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery

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Year : 2025 | Volume : 13 | 06 | Page :
    By

    Jisha Annie Geevarghese,

  • Chitra Khanwelkar,

  • Rashmi Gudur,

  • Bijoy Kumar Panda,

  1. , Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India
  2. , Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India
  3. , Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad-415539, Maharashtra, India
  4. , Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India

Abstract

Polymer chemistry has revolutionized pharmaceutical technology by enabling the development of advanced drug delivery systems with improved precision, stability, and therapeutic outcomes. This review explores the role of polymer design, synthesis, and functionalization in the development of responsive and targeted drug carriers. Emphasis is placed on various types of polymers—biodegradable, synthetic, natural, and stimuli-responsive—and their suitability for drug delivery platforms such as nanoparticles, micelles, hydrogels, dendrimers, and implants. The physicochemical properties of polymers, including architecture, crosslinking, and functional group availability, are discussed in relation to their drug loading efficiency, release kinetics, and bioavailability. The paper also details polymer synthesis techniques, including free radical and ring-opening polymerization, as well as green chemistry approaches aimed at sustainability. Case studies in oncology, vaccine delivery, gene therapy, and transdermal systems illustrate real-world applications. Additionally, regulatory and industrial considerations are addressed, highlighting the translational potential of polymer-based systems. This review underscores the interdisciplinary integration of polymer science and pharmaceutical technology, presenting polymer chemistry as a cornerstone for next-generation therapeutics. Future research directions focus on personalized medicine, responsive delivery systems, and scalable manufacturing of safe, effective polymer-based therapeutics.

Keywords: polymer chemistry, drug delivery, nanocarriers, hydrogels, smart polymers, PLGA, controlled release, pharmaceutical technology.

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How to cite this article:
Jisha Annie Geevarghese, Chitra Khanwelkar, Rashmi Gudur, Bijoy Kumar Panda. Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery. Journal of Polymer and Composites. 2025; 13(06):-.
How to cite this URL:
Jisha Annie Geevarghese, Chitra Khanwelkar, Rashmi Gudur, Bijoy Kumar Panda. Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery. Journal of Polymer and Composites. 2025; 13(06):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=224235


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Ahead of Print Subscription Review Article
Volume 13
06
Received 13/05/2025
Accepted 29/05/2025
Published 21/08/2025
Publication Time 100 Days
233

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