Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds

Year : 2026 | Volume : 14 | Special Issue 01 | Page : 7 13
    By

    Pratik Prakash Somade,

  • Atul R Chopade,

  1. Tutor, Department of Anatomy, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth, Karad, Maharashtra, India
  2. Associate Professor, Department of Pharmacology, Rajaram Institute of Pharmacy, Islampur, Maharashtra, India

Abstract

Polymer chemistry plays a fundamental role in advancing biomaterials for anatomical tissue engineering, particularly in the design of composite scaffolds that replicate the intrinsic characteristics of native tissues. The regeneration of damaged tissues, especially within anatomically complex structures such as bone, cartilage, and skin, necessitates biomaterials that closely emulate the hierarchical architecture and biological functions of native extracellular matrices (ECMs). The capacity to replicate both mechanical and biochemical cues of the natural ECM has positioned these scaffolds at the center of current strategies in regenerative medicine and pharmaceutical technology. This review presents a comprehensive examination of polymer-based composites, focusing on innovations reported between 2020 and 2025. It begins by categorizing polymers into synthetic, natural, and hybrid types and proceeds to discuss composite design principles including matrix–filler interactions, crosslinking, and surface functionalization. Furthermore, the review emphasizes structure–property relationships and their relevance in mimicking human tissues. The anatomical relevance of mechanical properties and scaffold geometry is evaluated for both load-bearing and soft tissues. Future directions highlight multi-scale modeling for personalized scaffold design, the emergence of sustainable and green polymers, and the potential of 4D printing for adaptive, patient-specific systems. By integrating recent research trends, this review provides a foundational understanding of how polymer chemistry continues to shape the future of functional and anatomically relevant biomaterials in regenerative medicine.

Keywords: 3D printing; 4D printing; anatomical modeling; biomimetic scaffolds; functional polymers; green biomaterials; polymer composites; regenerative medicine; tissue engineering.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Pratik Prakash Somade, Atul R Chopade. Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds. Journal of Polymer & Composites. 2025; 14(01):7-13.
How to cite this URL:
Pratik Prakash Somade, Atul R Chopade. Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds. Journal of Polymer & Composites. 2025; 14(01):7-13. Available from: https://journals.stmjournals.com/jopc/article=2025/view=224196


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Special Issue Subscription Review Article
Volume 14
Special Issue 01
Received 13/05/2025
Accepted 06/06/2025
Published 21/08/2025
Publication Time 100 Days
220

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