Polymer Chemistry and Its Applications in Pharmaceutical Composite Formulations

Year : 2025 | Volume : 13 | Special Issue 06 | Page : 216 221
    By

    Anuradha Niranjan Chivate,

  • Niranjan D. Chivate,

  • Kiran A. Wadkar,

  • Shubhangi A. Patil,

  1. Assistant Professor, Department of Pharmacology, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharshtra, India
  2. Associate Professor, Department of Pharmacology, Krishna Charitable Trust’s Krishna College of Pharmacy, Karad, Maharshtra, India
  3. Professor & Head, Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharshtra, India
  4. Head of Department, Department of Pharmacology, Krishna Charitable Trust’s Krishna College of Pharmacy, Karad, Maharshtra, India

Abstract

Polymer chemistry plays a critical role in pharmaceutical formulations, particularly in enhancing drug stability, bioavailability, and controlled release. Polymers are widely utilized in drug delivery systems. Polymers are widely used in pharmaceutical sciences for drug delivery, controlled release, and stability enhancement. This paper explores the role of polymers in the extraction and formulation of glycyrrhetinic acid from Glycyrrhiza glabra, a bioactive compound. Various polymer-based extraction and purification techniques are discussed, emphasizing their efficiency, yield improvement, and sustainability. These methods, including polymeric micelles, solid-phase extraction, and molecularly imprinted polymers, have been shown to enhance the selective isolation of glycyrrhetinic acid while reducing solvent consumption and environmental impact. Additionally, the formulation of glycyrrhetinic acid using polymer-based excipients such as surfactants and co-surfactants is reviewed. Polymers like polyvinyl alcohol, polyethylene glycol, and chitosan play a crucial role in stabilizing formulations, enhancing solubility, and enabling targeted delivery. The use of polymeric nanoparticles, hydrogels, further improves the bioavailability and therapeutic potential of glycyrrhetinic acid. This paper highlights the advancements in polymer-assisted techniques for extraction and formulation, showcasing their importance in modern pharmaceutical development. By integrating polymer chemistry, researchers can achieve higher drug efficacy, stability, and sustainability in herbal-based formulations.

Keywords: Polymer chemistry, glycyrrhetinic acid, pharmaceutical formulation, bioavailability, surfactants, controlled release, purification.

[This article belongs to Special Issue under section in Journal of Polymer & Composites (jopc)]

How to cite this article:
Anuradha Niranjan Chivate, Niranjan D. Chivate, Kiran A. Wadkar, Shubhangi A. Patil. Polymer Chemistry and Its Applications in Pharmaceutical Composite Formulations. Journal of Polymer & Composites. 2025; 13(06):216-221.
How to cite this URL:
Anuradha Niranjan Chivate, Niranjan D. Chivate, Kiran A. Wadkar, Shubhangi A. Patil. Polymer Chemistry and Its Applications in Pharmaceutical Composite Formulations. Journal of Polymer & Composites. 2025; 13(06):216-221. Available from: https://journals.stmjournals.com/jopc/article=2025/view=224182


References

  1. Zhuo Y, Zhao YG, Zhang Y. Enhancing drug solubility, bioavailability, and targeted therapeutic applications through magnetic nanoparticles. Molecules. 2024 Oct 13;29(20):4854.
  2. Liu M, Jing S, Xie T, Liu H, Bai L. Fabrication of a bio-based polymer adsorbent and its application for extraction and determination of glycosides from Huangqi Liuyi decoction. Journal of Pharmaceutical and Biomedical Analysis. 2024 Mar 15;240:115947.
  3. Cheng H, Jia X, Yuan D, Li H, Wang L, Fu T, Qiao H, Chen J, Wang Z, Cui X, Cheng J. Excipient-free nanodispersions dominated by amphiphilic glycosides for bioavailability enhancement of hydrophobic aglycones, a case of glycyrrhetinic acid with diammonium glycyrrhizinate. International Journal of Pharmaceutics. 2022 May 25;620:121770.
  4. Abasian P, Shakibi S, Maniati MS, Nouri Khorasani S, Khalili S. Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers. Polymers for Advanced Technologies. 2021 Mar;32(3):931-44.
  5. Hessel V, Tran NN, Asrami MR, Tran QD, Long NV, Escribà-Gelonch M, Tejada JO, Linke S, Sundmacher K. Sustainability of green solvents–review and perspective. Green Chemistry. 2022;24(2):410-37.
  6. Babich O, Ivanova S, Ulrikh E, Popov A, Larina V, Frolov A, Prosekov A. Study of the chemical composition and biologically active properties of Glycyrrhiza glabra extracts. Life. 2022 Nov 2;12(11):1772.
  7. Seker A. Adsorptive Recovery of Polyphenolic Antioxidants from Winery By-products Using Polyethylene Glycol (PEG) Grafted Silica Particles (Doctoral dissertation, Washington State University).
  8. Singh J, Nayak P. pH‐responsive polymers for drug delivery: trends and opportunities. Journal of Polymer Science. 2023 Nov 15;61(22):2828-50.
  9. Espinoza SM, Patil HI, San Martin Martinez E, Casanas Pimentel R, Ige PP. Poly-ε-caprolactone (PCL), a promising polymer for pharmaceutical and biomedical applications: Focus on nanomedicine in cancer. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020 Jan 22;69(2):85-126.
  10. Kuperkar K, Patel D, Atanase LI, Bahadur P. Amphiphilic block copolymers: their structures, and self-assembly to polymeric micelles and polymersomes as drug delivery vehicles. Polymers. 2022 Nov 3;14(21):4702.
  11. Hessel V, Tran NN, Asrami MR, Tran QD, Long NV, Escribà-Gelonch M, Tejada JO, Linke S, Sundmacher K. Sustainability of green solvents–review and perspective. Green Chemistry. 2022;24(2):410-37.
  12. Cheng H, Jia X, Yuan D, Li H, Wang L, Fu T, Qiao H, Chen J, Wang Z, Cui X, Cheng J. Excipient-free nanodispersions dominated by amphiphilic glycosides for bioavailability enhancement of hydrophobic aglycones, a case of glycyrrhetinic acid with diammonium glycyrrhizinate. International Journal of Pharmaceutics. 2022 May 25;620:121770.
  13. Wang H, Li R, Rao Y, Liu S, Hu C, Zhang Y, Meng L, Wu Q, Ouyang Q, Liang H, Qin M. Enhancement of the bioavailability and anti-inflammatory activity of glycyrrhetinic acid via novel Soluplus®—a glycyrrhetinic acid solid dispersion. Pharmaceutics. 2022 Aug 26;14(9):1797.
  14. Lei X, Liu B, Hou Q, Wang Y, Ahmadi M, Liu Z, Chen Z. Switchability and synergistic effect of a CO2-responsive surfactant with co-surfactants at an O/W interface: A molecular insight. Journal of Molecular Liquids. 2024 Jul 1;405:125051.
  15. Verma R, Mittal V, Pandey P, Bhatia S, Bhatia M, Karavasili C, Behl T, Al-Harrasi A, Tagde P, Kumar M, Kaushik D. Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances. Current Drug Delivery. 2023 Nov 1;20(9):1241-61.
  16. Gurram S, Jha DK, Shah DS, Kshirsagar MM, Amin PD. Insights on the critical parameters affecting the probiotic viability during stabilization process and formulation development. AAPS PharmSciTech. 2021 May 18;22(5):156.
  17. Goel M, Leung D, Famili A, Chang D, Nayak P, Al-Sayah M. Accelerated in vitro release testing method for a long-acting peptide-PLGA formulation. European Journal of Pharmaceutics and Biopharmaceutics. 2021 Aug 1;165:185-92.
  18. Kumar AP, Depan D, Tomer NS, Singh RP. Nanoscale particles for polymer degradation and stabilization—trends and future perspectives. Progress in polymer science. 2009 Jun 1;34(6):479-515.
  19. Pranjali Pokharkar, Namrata Gaonkar, Shashikiran N.D., Sachin Gugawad, Swapnil Taur, Savita Hadakar. Qualitative and Quantitative Effects of Non-Thermal Atmospheric Pressure Plasma and ErCr: YSGG Laser Activation on Surface Remineralization and Fluoride Release of Three Different Fluoride Varnishes. Journal of Polymer and Composites. 2024; 12(05):292-303.
  20. Abdeltawab H, Svirskis D, Sharma M. Formulation strategies to modulate drug release from poloxamer based in situ gelling systems. Expert Opinion on Drug Delivery. 2020 Apr 2;17(4):495-509.
  21. Prasad Tayde, Pronob Kumar Sanyal, Ajay Gaikwad, Shubha Joshi, Shivsagar Tewary, Amit Jadav. Evaluate and Compare the Effect of Water of Different Hardness Levels on the Surface Irregularity in 3 Different Heat-Polymerized Denture Base Resins. Journal of Polymer and Composites. 2024; 12(04):130-136.
  22. Joiner JB, Prasher A, Young IC, Kim J, Shrivastava R, Maturavongsadit P, Benhabbour SR. Effects of drug physicochemical properties on in-situ forming implant polymer degradation and drug release kinetics. Pharmaceutics. 2022 Jun 1;14(6):1188.
  23. Palaniappan M, Palanisamy S, Khan R, H.Alrasheedi N, Tadepalli S, Murugesan T mani, et al. Synthesis and suitability characterization of microcrystalline cellulose from Citrus x sinensis sweet orange peel fruit waste-based biomass for polymer composite applications. Journal of Polymer Research [Internet]. 2024 Mar 19;31(4). Available from: http://dx.doi.org/10.1007/s10965-024-03946-0
  24. Palanisamy S, Mayandi K, Palaniappan M, Alavudeen A, Rajini N, Vannucchi de Camargo F, et al. Mechanical Properties of Phormium Tenax Reinforced Natural Rubber Composites. Fibers [Internet]. 2021 Feb 1;9(2):11. Available from: http://dx.doi.org/10.3390/fib9020011
  25. Karuppiah G, Kuttalam KC, Palaniappan M, Santulli C, Palanisamy S. Multiobjective Optimization of Fabrication Parameters of Jute Fiber/Polyester Composites with Egg Shell Powder and Nanoclay Filler. Molecules [Internet]. 2020 Nov 27;25(23):5579. Available from: http://dx.doi.org/10.3390/molecules25235579
  26. Palanisamy S, Kalimuthu M, Santulli C, Palaniappan M, Nagarajan R, Fragassa C. Tailoring Epoxy Composites with Acacia caesia Bark Fibers: Evaluating the Effects of Fiber Amount and Length on Material Characteristics. Fibers [Internet]. 2023 Jul 17;11(7):63. Available from: http://dx.doi.org/10.3390/fib11070063
  27. Sumesh KR, Palanisamy S, Khan T, Ajithram A, Ahmed OS. Mechanical, morphological and wear resistance of natural fiber / glass fiber-based polymer composites. BioResources [Internet]. 2024 Apr 11;19(2):3271–89. Available from: http://dx.doi.org/10.15376/biores.19.2.3271-3289.
Special Issue Subscription Review Article
Volume 13
Special Issue 06
Received 12/03/2025
Accepted 19/05/2025
Published 08/08/2025
Publication Time 149 Days
196

Login


My IP

PlumX Metrics