Role of Polymeric Composites in Controlled Drug Release Systems

Year : 2025 | Volume : 13 | Special Issue 04 | Page : 453 465
    By

    Gharal R. R,

  • M. K. Nalawade,

  • Sameer Sawarkar,

  • Rakesh Raushan,

  1. Assistant Professor, Department of Pharmaceutics, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharashtra, India
  2. Professor, Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharashtra, India
  3. Associate Professor, Department of Civil Engineering, PCCOER, Ravet, Pune, Maharashtra, India
  4. Assistant Professor, Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharashtra, India

Abstract

In the realm of controlled drug release systems, polymeric composites have attracted a lot of interest as they possess several diverse characteristics that enable exact control of the drug delivery rate. This lowers adverse effects and increases the efficacy of treatment. Usually composed of biocompatible polymers combined with functional fillers like nanoparticles, ceramics, or hydrogels, these composites help to get the desired drug release patterns. Stable, biodegradable, and bioactive materials are crucial for polymeric composites used for regulated drug release. Drugs therefore are released to the target place over a certain period of time. It has been shown that adding nanoparticles or other fillers to polymer matrix increases mechanical strength, enhances drug encapsulation efficiency, and facilitates controlled degradation. Changing elements like the polymer composition, filler content, and crosslinking density helps the drug release kinetics to match various therapeutic demands. Because they release medications in reaction to outside signals like pH, temperature, or magnetic fields, stimuli-responsive polymeric composites are also very beneficial for localised therapy. This reduces the possibility of negative effects on a systemically level. Improved manufacturing techniques include electrospinning, 3D printing, and microfluidic systems have made it feasible to accurately regulate the structure of composites and the dosage of pharmaceuticals they contain, therefore enabling controlled release systems even more. Another interesting approach to create safe for the environment and long-lasting drug delivery systems from synthetic materials is incorporating natural polymers like chitosan and alginate to them.

Keywords: Polymeric composites, controlled drug release, drug delivery systems, nanoparticles, biodegradable polymers, stimuli-responsive systems.

[This article belongs to Special Issue under section in Journal of Polymer and Composites (jopc)]

How to cite this article:
Gharal R. R, M. K. Nalawade, Sameer Sawarkar, Rakesh Raushan. Role of Polymeric Composites in Controlled Drug Release Systems. Journal of Polymer and Composites. 2025; 13(04):453-465.
How to cite this URL:
Gharal R. R, M. K. Nalawade, Sameer Sawarkar, Rakesh Raushan. Role of Polymeric Composites in Controlled Drug Release Systems. Journal of Polymer and Composites. 2025; 13(04):453-465. Available from: https://journals.stmjournals.com/jopc/article=2025/view=211703


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Special Issue Subscription Review Article
Volume 13
Special Issue 04
Received 20/03/2025
Accepted 20/05/2025
Published 01/06/2025
Publication Time 73 Days
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