Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications

Open Access

Year : 2024 | Volume : 12 | Special Issue 06 | Page : 68 78
    By

    AK. Sanivarapu,

  • BK Babu,

  • D. Sravani,

  • U. Naga Babu,

  • SK Raziya,

  1. Associate Professor, Department of Chemistry, Aditya University, Suramplaem, Andhra Pradesh, India
  2. Associate Professor, Department of Engineering Chemistry, AU College of Engineering, Visakhapatnam, Andhra Pradesh, India
  3. Associate Professor, Department of Chemistry, Aditya College of Engineering and Technology Suramplaem, Andhra Pradesh, India
  4. Associate Professor, Department of Engineering Chemistry, SRKR College, Bhimavaram, Andhra Pradesh, India
  5. Assistant Professor, Department of Basic Sciences & Humanities, Viskha Institute of Engineering & Technology, Narava, Viskhapatnam, Andhra Pradesh, India

Abstract

A well established strategy is to introduce a biologically relevant organic molecule in coordination sphere of transition metal complexes to increase the selectivity and biocompatibility. Phenylacetic acid (PAA), an organic molecule with a phenyl functional group and a carboxylic acid functional group, is a phenylalanine that is generated from the naturally occurring auxin, which is extensively present in plants. The most promising outcomes in the battle against cancer and microbes come from metal complexes having ligands including bio molecules. In this work we synthesized two complexes of copper with phenyl acetic acid as primary ligand and pseudo halide and orthophenyl diamine as secondary ligands and characterized them by IR, LC-MS, UV and TG-DTA. Later investigated for antimicrobial and cytotoxic activity. The results indicate that these complexes of phenyl acetic acid have proved that they are good antibacterial agents in comparison with the cytotoxicity against MCF-7, A-431, HepG-2. The complex1 which is having pseudo halide as secondary ligand is found to have good battle against cancer and microbes than the other complex2 which is having orthophenyl diamine as secondary ligand. This is because pseudo halides have ability to disrupt cell membranes, enzymes or metabolic process in microorganisms.

Keywords: Phenylacetic acid, biocompatibility, biomolecules, metal complexes, ligand.

[This article belongs to Special Issue under section in Journal of Polymer and Composites (jopc)]

How to cite this article:
AK. Sanivarapu, BK Babu, D. Sravani, U. Naga Babu, SK Raziya. Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications. Journal of Polymer and Composites. 2024; 12(06):68-78.
How to cite this URL:
AK. Sanivarapu, BK Babu, D. Sravani, U. Naga Babu, SK Raziya. Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications. Journal of Polymer and Composites. 2024; 12(06):68-78. Available from: https://journals.stmjournals.com/jopc/article=2024/view=191127


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Special Issue Open Access Original Research
Volume 12
Special Issue 06
Received 24/04/2024
Accepted 25/06/2024
Published 23/09/2024
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