Encapsulation of Karela Extract in Polymer Nanoparticles

Open Access

Year : 2025 | Volume : 13 | Special Issue 01 | Page : 864 867
    By

    Arti Zende,

  • Rohit Ghanwat,

  • Shilpa Ruikar,

  • Girish Pathade,

  1. Research scholar, Department of Allied Sciences, Krishna Institute of Allied Sciences, Krishna Vishwa Vidyapeeth,Karad, Maharashtra, India
  2. MSc student, Department of Allied Sciences, Krishna Institute of Allied Sciences, Krishna Vishwa Vidyapeeth Karad, Maharashtra, India
  3. Assistant Professor, Department of Allied Sciences, Krishna Institute of Allied Sciences, Krishna Vishwa Vidyapeeth Karad, Maharashtra, India
  4. Professor, Department of Allied Sciences, Krishna Institute of Allied Sciences, Krishna Vishwa Vidyapeeth Karad, Maharashtra, India

Abstract

Karela (Momordica charantia) fruit extract possesses promising antibacterial properties. However, its direct application can be limited by factors like degradation and uncontrolled release. This study explores the encapsulation of Karela extract within biocompatible and biodegradable polymeric nanoparticles as a potential strategy to enhance its efficacy. The research investigates the development of nanoparticle systems using various polymers and their impact on the stability, controlled release, and antibacterial activity of the encapsulated Karela extract. The abstract will be further refined based on the specific polymers chosen and the evaluation methods employed. The overall goal is to demonstrate the feasibility of using polymer nanoparticles as a delivery system to improve the therapeutic potential of Karela extract against bacterial strains. Many plants, and their parts such as fruits, roots, stems, and extracts have medicinal value. Further the objective of the research was to examine the antibacterial function of Karela powder against laboratory strains. In this study, the karela fruit extract (25%) was prepared in the lab. The powder was diluted with sterile water and filtered through the bacteria-proof filter; a solution was used for the testing of the antimicrobial effectiveness of karela. The antimicrobial effectiveness of karela was assessed utilizing the agar disk diffusion method. Ten-fold dilutions of concentrated 10% aqueous extracts were made, and organisms were spread inoculated on the agar surface and wells were prepared by using a sterile borer and filled with different dilutions of karela solution. Eight isolates such as (four Gram-positive and four Gram-negative) were used as organisms under investigation, out of these eight only three were found organisms such as B. subtilis, M. luteus, and E. coli sensitive to both types of Karela solutions. Slightly increased sensitivity was observed to fresh Karela fruit extract. It indicates that the incorporation of Karela in a regular diet helps to maintain stomach health. Also, karela extract can be useful in controlling contamination of Bacillus subtilis, Micrococcus luteus, and E. coli.

Keywords: polymeric nanoparticles, Karela, antimicrobial activity, Escherichia coli, Balsam Pear, Terpenoids, Nanoparticles.

[This article belongs to Special Issue under section in Journal of Polymer and Composites (jopc)]

How to cite this article:
Arti Zende, Rohit Ghanwat, Shilpa Ruikar, Girish Pathade. Encapsulation of Karela Extract in Polymer Nanoparticles. Journal of Polymer and Composites. 2024; 13(01):864-867.
How to cite this URL:
Arti Zende, Rohit Ghanwat, Shilpa Ruikar, Girish Pathade. Encapsulation of Karela Extract in Polymer Nanoparticles. Journal of Polymer and Composites. 2024; 13(01):864-867. Available from: https://journals.stmjournals.com/jopc/article=2024/view=187120


References

  1. Álvarez-Martínez FJ, Barrajón-Catalán E, Micol V. Tackling antibiotic resistance with compounds of natural origin: A comprehensive review. Biomedicines. 2020 Oct 11;8(10):405.
  2. Muribeca AD, Gomes PW, Paes SS, da Costa AP, Gomes PW, Viana JD, Reis JD, Pamplona SD, Silva C, Bauermeister A, Santos LD. Antibacterial Activity from Momordica charantia L. Leaves and Flavones Enriched Phase. Pharmaceutics. 2022 Aug 26;14(9):1796.
  3. Naqvi SA, Ali S, Sherazi TA, Haq AU, Saeed M, Sulman M, Rizwan M, Alkahtani S, Abdel-Daim MM. Antioxidant, antibacterial, and anticancer activities of bitter gourd fruit extracts at three different cultivation stages. Journal of Chemistry. 2020;2020(1):7394751.
  4. Gupta M, Sharma S, Gautam AK, Bhadauria R. Momordica charantia Linn.(Karela): Nature’s silent healer. International Journal of Pharmaceutical Sciences Review and Research. 2011;11(1):32-7.
  5. Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian pacific journal of tropical disease. 2013 Apr 1;3(2):93-102.
  6. Liu Z, Gong J, Huang W, Lu F, Dong H. The effect of Momordica charantia in the treatment of diabetes mellitus: A review. Evidence‐Based Complementary and Alternative Medicine. 2021;2021(1):3796265.
  7. Mahwish, Saeed F, Arshad MS, Nisa MU, Nadeem MT, Arshad MU. Hypoglycemic and hypolipidemic effects of different parts and formulations of bitter gourd (Momordica Charantia). Lipids in health and disease. 2017 Dec;16:1-1.
  8. Gomaa EZ. Silver nanoparticles as an antimicrobial agent: A case study on Staphylococcus aureus and Escherichia coli as models for Gram-positive and Gram-negative bacteria. The Journal of general and applied microbiology. 2017;63(1):36-43.
  9. El-Ghwas DE, Yehia H. Antibacterial efficiency of natural products against multiple-drug-resistant clinical isolates. Egyptian Pharmaceutical Journal. 2022 Oct 1;21(4):432-9.
  10. Tribiana1&2, Gilly Anne, and Ernesto D. Dimaculangan. “AWARENESS, RECALL AND ATTITUDES OF PIZZA HUT CONSUMERS TOWARD DIGITAL ADVERTISING.” (2014).
  11. Mehta J, Rolta R, Dev K. Role of medicinal plants from North Western Himalayas as an efflux pump inhibitor against MDR AcrAB-TolC Salmonella enterica serovar typhimurium: In vitro and In silico studies. Journal of Ethnopharmacology. 2022 Jan 10;282:114589.
  12. Saeed F, Afzaal M, Niaz B, Arshad MU, Tufail T, Hussain MB, Javed A. Bitter melon (Momordica charantia): A natural healthy vegetable. International Journal of Food Properties. 2018 Jan 1;21(1):1270-90.
  13. Mwambete KD. The in vitro antimicrobial activity of fruit and leaf crude extracts of Momordica charantia: A Tanzania medicinal plant. African health sciences. 2009 Mar 20;9(1):34-9.
  14. Adadi P, Barakova NV, Krivoshapkina EF. Selected methods of extracting carotenoids, characterization, and health concerns: A review. Journal of agricultural and food chemistry. 2018 May 31;66(24):5925-47.
  15. Ramalingum N, Mahomoodally MF. The therapeutic potential of medicinal foods. Advances in Pharmacological and Pharmaceutical Sciences. 2014;2014(1):354264.
Special Issue Open Access Original Research
Volume 13
Special Issue 01
Received 02/04/2024
Accepted 01/08/2024
Published 04/12/2024
Publication Time 246 Days
440

Login


My IP

PlumX Metrics