Development of a Polymeric Detection System for Salivary Annexin-1: A Potential Tool for Point-of-Care Diagnostics in Periodontal Disease

Open Access

Year : 2024 | Volume : 12 | Special Issue 05 | Page : 101 110
    By

    Reema Shah,

  • Sameer Zope,

  • Girish Suragimath,

  • Siddharth Varma,

  • Vaishali Mashalkar,

  • Apurva Kale,

  1. PhD student, Department of Periodontology School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad, Maharshtra, India
  2. Professor, Department of Periodontology School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad, Maharshtra, India
  3. Professor, Department of Periodontology School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad, Maharshtra, India
  4. Assistant professor, Department of Periodontology School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad, Maharshtra, India
  5. Associate professor, Department of Periodontology School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad, Maharshtra, India
  6. Assistant professor, Department of Periodontology School of Dental Sciences, Krishna Vishwa Vidyapeeth Deemed to be University, Karad, Maharshtra, India

Abstract

Salivary annexin-1, a protein with anti-inflammatory properties, has emerged as a potential biomarker for periodontal disease. However, current detection methods, like ELISA, are often complex and require laboratory settings. This study explores the development of a novel polymeric detection system for the rapid and sensitive identification of salivary annexin-1. This system could leverage the unique properties of polymers to create a point-of-care diagnostic tool for: (1) early detection and monitoring of periodontal disease, particularly in diabetic populations, and (2) providing valuable insights into the inflammatory status of patients. The proposed system has the potential to offer several advantages, including: Rapid and user-friendly testing format suitable for clinical settings. High sensitivity and specificity for accurate annexin-1 detection. Potential for cost-effectiveness and portability compared to traditional methods. The development of such a polymeric detection system could revolutionize the diagnosis and management of periodontal disease, enabling early intervention and improved patient outcomes. Further, this study aimed to conduct a comparative assessment of salivary annexin-1 levels in Type-2 diabetic patients with and without periodontitis. Annexin-1, a glucocorticoid-regulated protein with anti-inflammatory properties, has been implicated in the regulation of inflammatory responses in periodontal disease. In this investigation, salivary annexin-1 levels were measured using enzyme-linked immunosorbent assay (ELISA) in diabetic patients with and without periodontitis, along with a control group of non-diabetic individuals. The results were statistically analyzed to determine any significant differences in annexin-1 levels between the diabetic groups with and without periodontitis, as well as compared to the control group. Findings from this study may provide insights into the role of annexin-1 in the pathogenesis of periodontal disease in diabetic individuals and its potential as a biomarker for periodontal health in diabetic populations.

Keywords: Polymeric detection system, Annexin-1, salivary biomarker, Type-2 diabetes, periodontitis, glucocorticoid-regulated protein, enzyme-linked immunosorbent assay (ELISA), periodontal disease, Polymorphism.

[This article belongs to Special Issue under section in Journal of Polymer and Composites (jopc)]

How to cite this article:
Reema Shah, Sameer Zope, Girish Suragimath, Siddharth Varma, Vaishali Mashalkar, Apurva Kale. Development of a Polymeric Detection System for Salivary Annexin-1: A Potential Tool for Point-of-Care Diagnostics in Periodontal Disease. Journal of Polymer and Composites. 2024; 12(05):101-110.
How to cite this URL:
Reema Shah, Sameer Zope, Girish Suragimath, Siddharth Varma, Vaishali Mashalkar, Apurva Kale. Development of a Polymeric Detection System for Salivary Annexin-1: A Potential Tool for Point-of-Care Diagnostics in Periodontal Disease. Journal of Polymer and Composites. 2024; 12(05):101-110. Available from: https://journals.stmjournals.com/jopc/article=2024/view=181771


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Special Issue Open Access Original Research
Volume 12
Special Issue 05
Received 02/04/2024
Accepted 24/07/2024
Published 31/07/2024
254

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