Neha Ghawate,
Shreyas Gagare,
Rohini Ghotale,
Akanksha Halle,
Ashwini Kamble,
- Assistant Professor, Department of Information Technology, Parvatibai Genba Moze College, Maharashtra, India
- Student, Department of Information Technology, Parvatibai Genba Moze College, Maharashtra, India
- Student, Department of Information Technology, Parvatibai Genba Moze College, Maharashtra, India
- Student, Department of Information Technology, Parvatibai Genba Moze College, Maharashtra, India
- Student, Department of Information Technology, Parvatibai Genba Moze College, Maharashtra, India
Abstract
A degenerative neurological state of affairs, Alzheimer’s disease (AD) gradually impairs cognitive and functional capacities, especially in people over 65. Early AD detection is crucial for efficient management and treatment prep. This study delves into novel approaches for the early detection of AD using non-invasive methods. We’ve implemented a blend of neuroimaging data analysis and machine learning algorithms to pinpoint markers indicative of the disease during its initial phases. Our methodology entails scrutinizing patterns within MRI and PET scans and correlating them with clinical assessments to refine diagnostic precision. The outcomes suggest that our approach significantly enhances early detection rates compared to conventional diagnostic techniques. We can detect small changes in the brain’s structure and operation that might occur before clinical symptoms by utilizing cutting-edge technology and predictive modeling. This research not only furthers our comprehension of Alzheimer’s Disease but also fosters a proactive and personalized approach to healthcare in neurodegenerative conditions. Our discoveries stand to aid healthcare professionals in making timelier and more accurate diagnoses, potentially enhancing patient outcomes through prompt intervention. he algorithms tested include Support Vector Machines (SVM), Random Forests, k-Nearest Neighbors (k-NN), and Convolutional Neural Networks (CNN). Each model was assessed for accuracy, sensitivity, and specificity in distinguishing between healthy controls, mild cognitive impairment (MCI), and AD patients. Experimental results reveal that CNN models applied to MRI data achieved the highest classification accuracy, demonstrating the effectiveness of deep learning techniques in detecting early structural changes associated with AD. Findings contribute to the development of robust, non-invasive diagnostic tools that leverage ML for early AD detection, paving the way for precision medicine in neurodegenerative disease management.
Keywords: Alzheimer’s Disease, Early Diagnosis, Cognitive Testing, Predictive Analytics, Medical Technology, Diagnostic Methods, Brain Disorders Prediction Algorithms
[This article belongs to Journal of Experimental & Applied Mechanics ]
Neha Ghawate, Shreyas Gagare, Rohini Ghotale, Akanksha Halle, Ashwini Kamble. Alzheimer’s Disease Detection Using ML Algorithm. Journal of Experimental & Applied Mechanics. 2024; 15(03):53-57.
Neha Ghawate, Shreyas Gagare, Rohini Ghotale, Akanksha Halle, Ashwini Kamble. Alzheimer’s Disease Detection Using ML Algorithm. Journal of Experimental & Applied Mechanics. 2024; 15(03):53-57. Available from: https://journals.stmjournals.com/joeam/article=2024/view=188444
References
- Alzheimer’s Association. (2022). Alzheimer’s disease facts and figures. Alzheimer’s & Dementia, 18(4), 700-789. https://doi.org/10.1002/alz.12328
- Liu, M., Cheng, D., & Yan, W. (2018). Classification of Alzheimer’s Disease by Combination of Convolutional and Recurrent Neural Networks Using FDG-PET Images. Frontiers in Neuroinformatics, 12, 35. https://doi.org/10.3389/fninf.2018.00035
- Weiner, M. W., Veitch, D. P., Aisen, P. S., et al. (2017). The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimer’s & Dementia, 13(4), 511-521. https://doi.org/10.1016/j.jalz.2017.01.005
- Zhang, D., Wang, Y., & Zhou, L. (2019). Multi-Modal Neuroimaging Feature Learning for Diagnosis of Alzheimer’s Disease: A Survey. IEEE Transactions on Neural Networks and Learning Systems, 30(9), 2830-2845. https://doi.org/10.1109/TNNLS.2018.2877370
- Sweeney, J. A., & Ryan, K. J. (2021). The Role of Biomarkers in the Diagnosis of Alzheimer’s Disease. Nature Reviews Neurology, 17(7), 405-417. https://doi.org/10.1038/s41582-021-00488-4
- Sinha, S., & Wang, C. Y. (2020). Machine Learning Approaches in Alzheimer’s Disease: A Review. Frontiers in Computational Neuroscience, 14, 29. https://doi.org/10.3389/fncom.2020.00029
- Ni, M., Wei, W., & Cheng, Y. (2021). An Overview of the Machine Learning Techniques in Alzheimer’s Disease Diagnosis. Frontiers in Aging Neuroscience, 13, 21. https://doi.org/10.3389/fnagi.2021.674857
- Yoon, S. W., & Kim, J. H. (2021). Early Detection of Alzheimer’s Disease with Machine Learning and Biomarkers. Journal of Alzheimer’s Disease, 83(1), 367-377. https://doi.org/10.3233/JAD-201008
- Frisoni, G. B., Fox, N. C., & Jack, C. R. (2010). The clinical use of structural MRI in Alzheimer disease. Nature Reviews Neurology, 6(2), 77-86. https://doi.org/10.1038/nrneurol.2009.225
- Bäckman, L., Jones, S., Berger, A. K., & Laukka, E. J. (2005). Cognitive impairment in preclinical Alzheimer’s disease: A meta-analysis. Neuropsychology, 19(4), 628-641. https://doi.org/10.1037/0894-4105.19.4.628
Journal of Experimental & Applied Mechanics
Volume | 15 |
Issue | 03 |
Received | 14/10/2024 |
Accepted | 30/10/2024 |
Published | 09/12/2024 |