A Promising Approach Towards Arthritis: Bacopa Monnieri

Year : 2025 | Volume : 14 | Issue : 03 | Page : 76 91
By

Vaishali Mundhe,

Pranjali Ugale,

Priya Daingade,

Sandhya Giri,

Vaibhavi Waykar,

Vishranti Diwate,

Tushar Shelke,

  1. Assistant Professor, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India
  2. Assistant Professor, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India
  3. Assistant Professor, Department of Pharmacy, GenbDepartment of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India
  4. Student, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India
  5. Student, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India
  6. Student, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India
  7. Principal, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi, Pune, Maharashtra, India

Abstract

Joint inflammation, pain, and a progressive loss of function are the hallmarks of arthritis, a chronic and crippling condition that frequently results in disability and a lower quality of life. The need for safer options is highlighted by the fact that while current therapy approaches, such as NSAIDs, corticosteroids, and disease-modifying antirheumatic medications, give symptomatic relief, they are usually linked to serious adverse effects. In this regard, the wellknown Ayurvedic medicinal plant Bacopa monnieri, also known as Brahmi, has drawn interest due to its encouraging anti-arthritic properties. Bacopa monnieri has long been used as a cognitive enhancer, but it also has strong anti-inflammatory, antioxidant, analgesic, and immunomodulatory qualities that could help treat arthritis. The main bioactive components of Bacopa monnieri are phytochemicals, including alkaloids, flavonoids, triterpenoids, and bacosides. These substances mainly work by lowering prostaglandin synthesis and altering the inflammatory cascade by blocking the activity of the cyclooxygenase-2 (COX-2) enzyme. Bacopa has been shown in experimental models to reduce arthritic joint edema, stabilize cellular membranes, and inhibit the release of lysosomal enzymes. Additionally, because oxidative stress is a major factor in cartilage degradation and synovial inflammation, its antioxidant capability helps to reduce it. Bacopa’s dual function in regulating oxidative pathways and pro-inflammatory mediators highlights its potential as a treatment for chronic inflammatory illnesses. Bacopa provides the benefits of reduced toxicity and less systemic adverse effects when compared to traditional allopathic medications. Bacopa has been used in Ayurvedic formulations, such as oils and decoctions, to help arthritis sufferers with pain, stiffness, and edema. Current studies also point to the possibility of using it in conjunction with conventional treatments in a synergistic way. Future developments in tailored delivery methods and nanoformulations could increase bioavailability. But even with its medicinal potential, further research is still needed to determine long-term safety, the best dosage, and widespread clinical efficacy. In summary, by fusing contemporary pharmacological research with age-old Ayurvedic knowledge, Bacopa monnieri shows promise as a natural remedy for the treatment of arthritis. It is positioned as a possible substitute or supplement to traditional therapies due to its capacity to minimize side effects, protect cartilage, and reduce inflammation. For its successful incorporation into arthritis treatment plans, standardized formulations and therapeutic guidelines must be established through future clinical trials and mechanistic investigations

Keywords: Bacopa monnieri, Arthritis, Anti-inflammatory, Phytochemicals, Ayurvedic medicine

[This article belongs to Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy ]

How to cite this article: Vaishali Mundhe, Pranjali Ugale, Priya Daingade, Sandhya Giri, Vaibhavi Waykar, Vishranti Diwate, Tushar Shelke. A Promising Approach Towards Arthritis: Bacopa Monnieri. Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy. 2025; 14(03):76-91.
How to cite this URL: Vaishali Mundhe, Pranjali Ugale, Priya Daingade, Sandhya Giri, Vaibhavi Waykar, Vishranti Diwate, Tushar Shelke. A Promising Approach Towards Arthritis: Bacopa Monnieri. Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy. 2025; 14(03):76-91. Available from: https://journals.stmjournals.com/joayush/article=2025/view=253960

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Regular Issue Subscription Review Article
Volume 14
Issue 03
Received 10/09/2025
Accepted 26/09/2025
Published 27/09/2025
Publication Time 17 Days

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