Km Priyanka Singh,
Rifat Siraj,
- Student, Department of Dental Sciences, Adesh Institute of Dental Science and Research, Adesh University, Bathinda, Punjab, India
- Student, Department of Dental Sciences, Adesh Institute of Dental Science and Research, Adesh University, Bathinda, Punjab, India
Abstract
H.I.V remains a significant health issue of great concern to the world and with great impact to the individuals and communities on a global scale. This is a comprehensive literature review on the epidemiology of HIV, including both the world prevalence of HIV and the regional variations, especially in sub-Saharan Africa. It discusses the most important modes of transmission including sexual, blood, and vertical transmission and investigates the effectiveness of prevention measures including behavioral interventions, pre-exposure prophylaxis (PrEP) and the current research on vaccines. The obstacles therein encountered in resource-limited settings and the development of drug resistance are also covered in the review. In addition, it brings out international initiatives to contain HIV such as the 90-90-90 goals and the contribution of technology towards improving HIV care. There are directions in treatment of HIV in the future such as long-acting formulations of ART and possible cures. This review highlights the role of further research and policy formulation, as well as global community, in the fight against HIV epidemic and enhancing health outcomes of the affected populations.
Keywords: HIV, epidemiology, prevention measures, 90-90-90 goals, drug resistance, ART, global health, PrEP, HIV vaccine.
[This article belongs to International Journal of Virus Studies ]
Km Priyanka Singh, Rifat Siraj. Impact of HIV on Global Health: A Comprehensive Review of Epidemiology and Interventions. International Journal of Virus Studies. 2026; 03(01):39-45.
Km Priyanka Singh, Rifat Siraj. Impact of HIV on Global Health: A Comprehensive Review of Epidemiology and Interventions. International Journal of Virus Studies. 2026; 03(01):39-45. Available from: https://journals.stmjournals.com/ijvs/article=2026/view=237727
References
- Global AI. Update. Seizing the moment, tackling entrenched inequalities to end epidemics. Published online. 2020;384.
- Phillips JA. HIV and Workers. Workplace Health & Safety. 2021 Nov;69(11):541-.
- Kallings LO. The first postmodern pandemic: 25 years of HIV/AIDS. Journal of internal medicine. 2008 Mar;263(3):218-43.
- Keen PM. Improving the timely diagnosis of HIV among gay and other men who have sex with men (Doctoral dissertation, University of New South Wales (Australia)).
- Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. New England journal of medicine. 2012 Aug 2;367(5):399-410.
- Lepere P. Achieving HIV treatment targets in the era of digital health: the promises and challenges of mHealth..
- Zhang J, Gao F, Ye Z. Remote consultation based on mixed reality technology. Global Health Journal. 2020 Mar 1;4(1):31-2.
- Hutton ML, Pehlivanoglu H, Vidor CJ, James ML, Thomson MJ, Lyras D. Repurposing auranofin as a Clostridioides difficile therapeutic. Journal of Antimicrobial Chemotherapy. 2020 Feb 1;75(2):409-17.
- Tsekwe NO. Bridging The Divide: Translating HIV Awareness Into Sustainable HIV Prevention In Vulnerable Communities. European Journal of Emerging Scientific Research. 2025 Jan 3;2(01):01-12.
- Balogun K, Slev PR. Towards achieving the end of the HIV epidemic: advances, challenges and scaling-up strategies. Clinical biochemistry. 2023 Jul 1;117:53-9.
- Perry HB, Zulliger R, Rogers MM. Community health workers in low-, middle-, and high-income countries: an overview of their history, recent evolution, and current effectiveness. Annual review of public health. 2014 Mar 18;35:399-421.
- Khatri RB, Endalamaw A, Erku D, Wolka E, Nigatu F, Zewdie A, Assefa Y. Enablers and barriers of community health programs for improved equity and universal coverage of primary health care services: A scoping review. BMC primary care. 2024 Oct 29;25(1):385.
- Gray JM, Cohn DL. Tuberculosis and HIV coinfection. InSeminars in respiratory and critical care medicine 2013 Feb (Vol. 34, No. 01, pp. 032-043). Thieme Medical Publishers.
- Monroe AK, Polyak CS, Castel AD, Esber AL, Byrne ME, Maswai J, Owuoth J, Maganga L, Bahemana E, Adamu Y, Iroezindu M. Clinical similarities and differences between two large HIV cohorts in the United States and Africa. Plos one. 2022 Apr 4;17(4):e0262204.
- Azman AS, Moore SM, Lessler J. Surveillance and the global fight against cholera: setting priorities and tracking progress. Vaccine. 2020 Feb 29;38:A28-30.
- Gupta GR, Parkhurst JO, Ogden JA, Aggleton P, Mahal A. Structural approaches to HIV prevention. The lancet. 2008 Aug 30;372(9640):764-75.
- Willis VC, Thomas Craig KJ, Jabbarpour Y, Scheufele EL, Arriaga YE, Ajinkya M, Rhee KB, Bazemore A. Digital health interventions to enhance prevention in primary care: scoping review. JMIR medical informatics. 2022 Jan 21;10(1):e33518.
- Lovly CM, Shaw AT. Molecular pathways: resistance to kinase inhibitors and implications for therapeutic strategies. Clinical Cancer Research. 2014 May 1;20(9):2249-56.
- Parekh BS, Ou CY, Fonjungo PN, Kalou MB, Rottinghaus E, Puren A, Alexander H, Hurlston Cox M, Nkengasong JN. Diagnosis of human immunodeficiency virus infection. Clinical microbiology reviews. 2018 Dec 19;32(1):10-128.
- Sobia P, Archary D. Preventive HIV vaccines-leveraging on lessons from the past to pave the way forward. Vaccines. 2021 Sep 8;9(9):1001.
- Threats M, Brawner BM, Montgomery TM, Abrams J, Jemmott LS, Crouch PC, Freeborn K, Kamitani E, Enah C. A review of recent HIV prevention interventions and future considerations for nursing science. Journal of the Association of Nurses in AIDS Care. 2021 May 1;32(3):373-91.
- Mallik S. Health Geography. InThe Encyclopedia of Human Geography 2026 Jan 22 (pp. 583-590). Cham: Springer Nature Switzerland.
- Kariuki W, Manuel JI, Kariuki N, Tuchman E, O’Neal J, Lalanne GA. HIV and smoking: associated risks and prevention strategies. HIV/AIDS-Research and Palliative Care. 2015 Dec 24:17-36.
- Esparza J. Lessons from history: what can we learn from 300 years of pandemic flu that could inform the response to COVID-19?. American journal of public health. 2020 Aug;110(8):1160.
- Tang Y, Yan H, Luo Y, Zhang T, Liu Y, Wang S, Yang Z. Effectiveness of mobile health (mHealth) interventions on ART adherence among people living with HIV in low-and middle-income countries: a systematic review and meta-analysis. AIDS care. 2026 Mar 4;38(3):435-51.
- Fox MP, Mazimba A, Seidenberg P, Crooks D, Sikateyo B, Rosen S. Barriers to initiation of antiretroviral treatment in rural and urban areas of Zambia: a cross‐sectional study of cost, stigma, and perceptions about ART. Journal of the International AIDS Society. 2010 Jan;13(1):8-.
- Moyo E, Moyo P, Mangwana H, Murewanhema G, Dzinamarira T. Facilitators and Barriers to Antiretroviral Therapy Adherence Among Adolescents and Young Adults in Sub-Saharan Africa: A Scoping Review. Adolescents. 2025 Mar 31;5(2):10.
- Strathdee SA, Martin NK, Pitpitan EV, Stockman JK, Smith DM. What the HIV pandemic experience can teach the United States about the COVID-19 response. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2021 Jan 1;86(1):1-0.
- Bhagat M, Kamal R, Sharma J, Kaur K, Sharma A, Singh TG, Bhatia R, Awasthi A. Gene therapy: towards a new era of medicine. AAPS PharmSciTech. 2024 Dec 19;26(1):17.
- Zubair A, Jawad M, Khan L, Hidayat Z, Ali M. Advancing HIV Treatment Through Nanoparticles: A Precision Medicine Approach. Current HIV Research. 2025.

International Journal of Virus Studies
| Volume | 03 |
| Issue | 01 |
| Received | 05/02/2026 |
| Accepted | 05/02/2026 |
| Published | 20/02/2026 |
| Publication Time | 15 Days |
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