Unmasking Human Metapneumovirus: The Emerging Threat to Vulnerable Populations

Year : 2025 | Volume : 02 | Issue : 01 | Page : 16 24
    By

    Alisha Arzoo,

  1. Reasearcher, Department of Virology, The School of Interdisciplinary Studies,Jamia Hamdard,New Delhi-110062., New Delhi, India

Abstract

Human Metapneumovirus (HMPV) is a contagious respiratory virus that commonly spreads among individuals. It can cause serious infections, especially in high-risk groups like infants, older adults, and individuals with weakened immune systems.It is a major contributor to acute respiratory illnesses. Since its discovery in 2001, HMPV has been identified as a common cause of both upper and lower respiratory tract illnesses, with clinical presentations ranging from mild symptoms to severe conditions like bronchiolitis and pneumonia. Accurate diagnosis relies on advanced laboratory techniques, including polymerase chain reaction (PCR) and antigen detection methods. Currently, treatment is primarily supportive, focusing on symptom relief and the prevention of complications, as no specific antiviral therapies or vaccines are available. Preventive measures emphasizing hygiene practices and respiratory etiquette are crucial in minimizing transmission. Continued research on vaccines and targeted treatments is crucial for better managing HMPV infections. This review explores various aspects of HMPV, including its history, structure, spread, how it causes disease, symptoms, diagnostic methods, and possible treatment options. By bringing together the latest information, it aims to emphasize HMPV’s impact on global respiratory health and the importance of ongoing efforts to develop effective prevention and treatment strategies.Human Metapneumovirus (HMPV) is a contagious respiratory virus that commonly spreads among individuals. It can cause serious infections, especially in high-risk groups like infants, older adults, and individuals with weakened immune systems.It is a major contributor to acute respiratory illnesses. Since its discovery in 2001, HMPV has been identified as a common cause of both upper and lower respiratory tract illnesses, with clinical presentations ranging from mild symptoms to severe conditions like bronchiolitis and pneumonia. Accurate diagnosis relies on advanced laboratory techniques, including polymerase chain reaction (PCR) and antigen detection methods. Currently, treatment is primarily supportive, focusing on symptom relief and the prevention of complications, as no specific antiviral therapies or vaccines are available. Preventive measures emphasizing hygiene practices and respiratory etiquette are crucial in minimizing transmission. Continued research on vaccines and targeted treatments is crucial for better managing HMPV infections. This review explores various aspects of HMPV, including its history, structure, spread, how it causes disease, symptoms, diagnostic methods, and possible treatment options. By bringing together the latest information, it aims to emphasize HMPV’s impact on global respiratory health and the importance of ongoing efforts to develop effective prevention and treatment strategies.

Keywords: Human Metapneumovirus (HMPV), Respiratory infections, Diagnosis and treatment, Virus transmission, Preventive measures.

[This article belongs to International Journal of Virus Studies ]

How to cite this article:
Alisha Arzoo. Unmasking Human Metapneumovirus: The Emerging Threat to Vulnerable Populations. International Journal of Virus Studies. 2025; 02(01):16-24.
How to cite this URL:
Alisha Arzoo. Unmasking Human Metapneumovirus: The Emerging Threat to Vulnerable Populations. International Journal of Virus Studies. 2025; 02(01):16-24. Available from: https://journals.stmjournals.com/ijvs/article=2025/view=203432


References

  1. Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nature medicine. 2001 Jun;7(6):719-24.
  2. Boivin G, De Serres G, Côté S, Gilca R, Abed Y, Rochette L, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis. 2003;9(6):634-40.
  3. Panda S, Mohakud NK, Pena L, Kumar S. Human metapneumovirus: Review of an important respiratory pathogen. Int J Infect Dis. 2014;25:45-52.
  4. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5):443-50.
  5. Xepapadaki P, Psarras S, Bossios A, Tsolia M, Gourgiotis D, Liapi-Adamidou G, et al. Human metapneumovirus as a causative agent of acute bronchiolitis in infants. J Clin Virol. 2004;30(3):267-70.
  6. Falsey AR, Erdman D, Anderson LJ, Walsh EE. Human metapneumovirus infections in young and elderly adults. J Infect Dis. 2003;187(5):785-90.
  7. Esper F, Boucher D, Weibel C, Martinello RA, Kahn JS. Human metapneumovirus infection in the United States: Clinical manifestations associated with a newly emerging respiratory infection in children. Clin Infect Dis. 2003;36(6):797-802.
  8. Feuillet F, Lina B, Rosa-Calatrava M, Boivin G. Ten years of human metapneumovirus research. J Clin Virol. 2012;53(2):97-105.
  9. Nissen MD, Siebert DJ, Mackay IM, Sloots TP, Withers SJ. Evidence of human metapneumovirus in Australian children. Med J Aust. 2002;176(4):188-92.
  10. Peret TC, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus AD, et al. Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis. 2002;185(11):1660-3.
  11. Savolainen-Kopra C, Amiryousefi A, Vainionpää R, Al-Hello H, Peltola V, Ziegler T, et al. Single treatment with oral oseltamivir does not prevent secondary transmission of influenza or human metapneumovirus infections within families. Antiviral Ther. 2011;16(6):805-9.
  12. Kahn JS. Epidemiology of human metapneumovirus. Clin Microbiol Rev. 2006;19(3):546-57.
  13. McCracken JP, Prill MM, Arvelo W, Lindblade KA, López MR, Estevez A, et al. Respiratory syncytial virus infection in Guatemala, 2007–2012. J Infect Dis. 2013;208(Suppl 3):S197-206.

Regular Issue Subscription Review Article
Volume 02
Issue 01
Received 06/02/2025
Accepted 01/03/2025
Published 05/03/2025
Publication Time 27 Days


Login


My IP

PlumX Metrics