Aman Suresh T.
Jeevan T.N.
Omkarswamy Maradimath
Abstract
Solubility enhancement holds significant importance in the field of pharmaceutical research as it aims to augment the solubility and bioavailability of drugs that possess low solubility. Poorly soluble drugs pose a considerable challenge in drug development due to their tendency to display inadequate absorption, bioavailability, and therapeutic efficacy. The advancement of solubility enhancement techniques encompasses a wide range of approaches, including physical and chemical methods, as well as innovative technologies such as cyclodextrin complexes, co-crystals, nanoemulsions, amorphous solid dispersions, and supercritical fluid technology. The choice of solubility enhancement technique depends on the specific physicochemical properties of the drug and the desired formulation characteristics. However, it is important to consider the stability, toxicity, and pharmacokinetic profile of the drug when selecting a solubility enhancement strategy. Solubility enhancement is an ongoing challenge in drug development, but advancements in solubility enhancement techniques offer promising solutions for improving drug delivery and efficacy. This audit gives an idea of different dissolvability upgrade methods and their potential applications in sedate advancement. Extra examination and headway in this space might result within the creation of novel and upgraded choices
Keywords: Solubility, cyclodextrin, nanosuspension, hydrophobic drugs, bioavailability.
[This article belongs to International Journal of Vaccines(ijv)]
References
- Limbachiya MI. Solubility enhancement techniques for poorly soluble drugs: A review. IJPRD, 2011; 4(4):71-86
- Patil MS, Godse SG, Saudagar RB. Solubility Enhancement by Various Techniques: An Overview.World Journal of Pharmacy and Pharmaceutical Sciences. 2013; 2(6):4558-4572.
- Pawar AR, Choudhari PD. Novel Techniques for Solubility, Dissolution Rate and Bioavailability Enhancement of Class II & IV drugs. Asian Journal of Biomedical & Pharmaceutical Science. 2012; 13:9-14.
- Godse SZ, Patil MS, Kothavade SM, Saudagar RB.Techniques for Solubility Enhancement of Hydrophobic Drugs: A Review, J Adv. Pharm. Edu. & Res. 2013;3(4):403-414.
- Vemula VR, Lagishetty V, Lingala S. Solubility enhancement techniques, International Journal of Pharmaceutical Sciences Review and Research. 2010;5(1):41-51.
- Savjani KT, Gajjar AK, Savjani JS. Drug Solubility:Importance and Enhancement Techniques. ISRN Pharmaceutics Article ID195727, 2012, 1-10, doi:10.5402/2012/195727.
- Blagden, M. de Matas, P.T. Gavan, P. York. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates, Advanced Drug Delivery Reviews, 2007; 59(7):617-630.
- Vogt, K. Kunath, J.B. Dressman. Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations, European Journal of Pharmaceutics and Biopharmaceutics. 2008; 68(2):283-288.
- Chaumeil JC. Micronization: a method of improving the bioavailability of poorly soluble drugs, Methods and Findings in Experimental and Clinical Pharmacology. 1998; 20(3):211-215.
- Ahmad Z, Maurya N, Mishra KS, Khan I. Solubility Enhancement of Poorly Water-Soluble Drugs: A Review.International Journal of Pharmacy & Technology. 2011;3(1):807-823.
- Riehemann K, Fuchs H, Schneider SW, Luger TA, Godin~ 28 ~B, Farrari M. Nanomedicine-Challenge and Perspectives.Chem. Int. Ed. Engl. 2009; 48:872-897.
- MofizurRahman, Abul Bashar Ripon Khalipha, Jamal Ahmed, Md. AbShuaibRafshanjani, ShanjidaHaque, Methods of Solubility and Dissolution Enhancement for Poorly Water-Soluble Drugs: A Review. 2014; 3(5):107-130.
- Sareen S, Mathew G, Joseph L. Improvement In Solubility of Poor Water-Soluble Drugs By Solid Dispersion, International Journal of Pharmaceutical Investigation: Review Article. 2012; 2(1):12-17.
- Mohanachandran PS, Sindhumol PG, Kiran TS.Enhancement of Solubility and Dissolution Rate: An Overview, Pharmacie Globale International Journal of Compehensive Pharmacy. 2010; 1(4):1-10.
- Rantakyla M. Particle production by supercritical antisolvent processing techniques, Licentiate’s Thesis, Helsinki University of Technology, Department of Chemical Technology, Espoo, 2004.
- Syed IM, Pavani E. The Liquisolid technique: based drug delivery system, Int. J PharmSci and Drug Resea rch. 2012; 4(2):88-96.
- Vajir S. Liquisolid Compct: a novel approch to enhance bioavailability of poorly soluble drug. Int. J Pharmacy. 2012; 2(3):586-590.
- Spiridon Spireas, Bolton SM. Liquisolids: Liquisolid system and methods of preparing the same. United States Patent, 1998.
- Nagabandi VK, Tadikonda R, Jayaveera KN.Enhancement of dissolution rate and micromeritics of poorly soluble drug ketopr ofen by liquisolid technique, Journal of Pharmaceutical and Biomedical Sciences. 2011; 9(9):1-6.
- Khalid ME, Ahmed M. Samy, Mohamed I. Fetouh for mulation and evaluation of Rofecoxib Liquisolid Tablets, International Journal of Pharmaceutical Sciences Review and Research. 2010; 3(1):135-142.
- Chandel P, Raj K, Kapoor A. Liquisolid technique: an approach for enhancement of solubility, Journal of Drug Delivery & Therapeutics. 2013; 3(4):131-137.
- Gavali SM, Pacharane SS, Sankpal SV, Jadhav KR, Kadam VJ. Liquisolid Compact: A new technique for enhancement of drug dissolution, International Journal of Research in Pharmacy And Chemistry. 2011; 1(3):705-713.
| Volume | 01 |
| Issue | 01 |
| Received | March 10, 2024 |
| Accepted | March 14, 2024 |
| Published | March 28, 2024 |