A Narrative Review on Osteogenesis Imperfecta and Its Management

Year : 2024 | Volume :02 | Issue : 01 | Page : 1-10
By

Asad Jamal Ansari

Guisia Khan

Kudshiya Khan

  1. Faculty Integral University Uttar Pradesh India
  2. Researcher Integral University Uttar Pradesh India
  3. Researcher Integral University Uttar Pradesh India

Abstract

Osteogenesis imperfecta (OI), sometimes referred to as brittle bone disease, is a heterogeneous illness characterized by short stature, several fractures, and distorted bones. The main contributing factor to OI is mutations in the genes needed to produce type 1 collagen. While severe OI is perinatally fatal, mild OI can occasionally not be detected until maturity. The frequency of Osteogenesis imperfecta ranges from about 1:15,000 to 1:20,000 births. Five kinds of the illness are commonly differentiated, ranging in severity from moderate (type I) to deadly (type II). Types III and IV are serious types that permit survival during the newborn period, but type V has a mild to moderate phenotype and interosseous membrane calcification. The majority of the time, mutations in the col I genes result in a decrease in the production of common type I collagen (col I) or the synthesis of uncommon collagen. Moreover, it has been shown that mutations in the genes responsible for osteoblast development, col I processing, and synthesis have occurred. The objective of this study is to review the research on the current medical treatments for osteogenesis imperfecta (OI) in patients. The treatments that are currently available aim to reduce or eliminate symptoms, prevent fractures, and build bone mass. Medications like bisphosphonates, denosumab, and teriparatide are frequently used to treat OI.

Keywords: Osteogenesis imperfecta, bisphosphonates, denosumab, teriparatide, physiotherapy

[This article belongs to International Journal of Orthopedic Nursing and Practices(ijornp)]

How to cite this article: Asad Jamal Ansari, Guisia Khan, Kudshiya Khan. A Narrative Review on Osteogenesis Imperfecta and Its Management. International Journal of Orthopedic Nursing and Practices. 2024; 02(01):1-10.
How to cite this URL: Asad Jamal Ansari, Guisia Khan, Kudshiya Khan. A Narrative Review on Osteogenesis Imperfecta and Its Management. International Journal of Orthopedic Nursing and Practices. 2024; 02(01):1-10. Available from: https://journals.stmjournals.com/ijornp/article=2024/view=148709

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Regular Issue Subscription Review Article
Volume 02
Issue 01
Received May 10, 2024
Accepted May 22, 2024
Published May 29, 2024
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