Maitry H. Rathod,
Hardini P. Chauhan,
Vaibhavi J. Panchal,
Hetvi H. Patel,
Bisojeet R. Khandai,
- Student, Department of Pharmacy Practice, Maliba Pharmacy College, Uka Tarsadia University, Bardoli, Gujarat, India
- Student, Department of Pharmacy Practice, Maliba Pharmacy College, Uka Tarsadia University, Bardoli, Gujarat, India
- Student, Department of Pharmacy Practice, Maliba Pharmacy College, Uka Tarsadia University, Bardoli, Gujarat, India
- Student, Department of Pharmacy Practice, Maliba Pharmacy College, Uka Tarsadia University, Bardoli, Gujarat, India
- Student, Department of Pharmacy Practice, Maliba Pharmacy College, Uka Tarsadia University, Bardoli, Gujarat, India
Abstract
Biological membranes are important structures that control cellular work, signal transmission, transport, and communication. Dysfunction of membranes has been considered in the development of many diseases, such as cancer, neurodegenerative diseases, and infections, with the distortion of lipid composition, protein activity, and cellular connections involved in the pathogenesis of the disease. The damage on membrane can be caused by oxidative stress, genetic mutation, and environmental influence to disrupt cellular homeostasis. Some therapeutic methods, including drug delivery systems, gene therapy, and membrane stabilization therapies, have the potential to repair membrane integrity and the outcomes of disease. The future studies are aimed at understanding the mechanisms of membrane dynamics, and special attention will be paid to personalized medicine as well as membrane-targeted therapies. The development of membrane biophysics, imaging methods, and gene editing technologies will make our current capacity to create targeted remedies more advanced. Learning about membrane changes at the molecular level will open new vistas for treating diseases and improving patient treatment.
Keywords: Biological membranes, cancer, drug delivery, gene therapy, membrane dysfunction, membrane stabilization, neurodegenerative diseases
[This article belongs to International Journal of Membranes ]
Maitry H. Rathod, Hardini P. Chauhan, Vaibhavi J. Panchal, Hetvi H. Patel, Bisojeet R. Khandai. Biological Membranes: Structure, Function, and Their Roles in Disease Pathophysiology. International Journal of Membranes. 2026; 03(01):38-46.
Maitry H. Rathod, Hardini P. Chauhan, Vaibhavi J. Panchal, Hetvi H. Patel, Bisojeet R. Khandai. Biological Membranes: Structure, Function, and Their Roles in Disease Pathophysiology. International Journal of Membranes. 2026; 03(01):38-46. Available from: https://journals.stmjournals.com/ijm/article=2026/view=238396
References
- Kuzu OF, Granerud LJ, Saatcioglu Navigating the landscape of protein folding and proteostasis: From molecular chaperones to therapeutic innovations. Signal Transduct Target Ther. 2025;10:358.
- Arnold C, Tahmaz I, Chapon ML, Maayouf H, Luchnikov V, Milan JL, et al. Bending the rules: Curvature’s impact on cell biology. BMC Biol. 2025;23:296.
- Wan L, Ge X, Xu Q, Huang G, Yang T, Campbell KP, et al. Structure and assembly of the dystrophin glycoprotein complex. Nature. 2025;637:1252–1260.
- Spinelli S, Marino A, Remigante A, Morabito R. Redox homeostasis in red blood cells: From molecular mechanisms to antioxidant strategies. Curr Issues Mol Biol. 2025;47:655.
- Zayani Z, Matinahmadi A, Tavakolpournegari A, Bidooki SH. Exploring stressors: Impact on cellular organelles and implications for cellular functions. Stresses. 2025;5:26.
- Xing H, Li R, Huang Z, Gao Z, Mao Q, Shen Y, et al. Engineered cell membrane-coated keratin nanoparticles attenuated intervertebral disc degeneration by remodeling the disc Adv Healthc Mater. 2025;14:2404173.
- Cheng YF, Zhao YJ, Chen C, Zhang F. Heavy metals toxicity: Mechanism, health effects, and therapeutic interventions. MedComm. 2025;6:e70241.
- Alvarez-Lorenzo C, Ramirez-Romero A, Peixoto D, Vivero-Lopez M, Rodríguez-Moldes I, Concheiro A. Biomimetic cell membrane-coated scaffolds for enhanced tissue regeneration. Adv Mater. 2025;37:2507084.
- Garab G, Böde K, Dlouhý O, Násztor Z, Karlický V, Dér A, et al. Lipid polymorphism of plant thylakoid membranes: The dynamic exchange model—facts and hypotheses. Physiol Plant. 2025;177:e70230.
- Jain N, Singh A, Bhatia D. DNA-amphiphilic nanostructures: Synthesis, characterization and applications. Nanoscale. 2025.
- Kaur J, Thakran A, Naqvi Recent advances in cell membrane-based biomimetic delivery systems
for Parkinson’s disease: Perspectives and challenges. Asian J Pharm Sci. 2025;20:101060.
- Priyadarsini S, Upadhyay VR, Pashupathi M, Mishra R. Physiology of membranes. In: Fundamentals of veterinary pathophysiology. CRC Press; 2025. p. 56–69.
- Herrera AS, Arias Esparza M. The unsuspected ability of the human cell to oxygenate itself: Applications in cell biology. Med Res Arch. 2025;13(3).
- Zhu Y, Verkhratsky A, Chen H, Yi Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases. Acta Physiol (Oxf). 2025;241:e14283.
- Kim S, Jung UJ, Kim The crucial role of the blood–brain barrier in neurodegenerative diseases: Mechanisms of disruption and therapeutic implications. J Clin Med. 2025;14:386.
- Radulovic M, Yang C, Stenmark H. Lysosomal membrane homeostasis and its importance in physiology and disease. Nat Rev Mol Cell Biol. 2025:1–7.
- Li L, Guo Z, Zhao Y, Liang C, Zheng W, Tian W, et The impact of oxidative stress on abnormal lipid metabolism-mediated disease development. Arch Biochem Biophys. 2025:110348.
- Jomova K, Alomar SY, Valko R, Fresser L, Nepovimova E, Kuca K, et al. Interplay of oxidative stress and antioxidant mechanisms in cancer development and Arch Toxicol. 2025:1–47.
- Ning J, Qiao L. Ferroptosis: Molecular mechanisms, pathophysiology, and role in pediatric pulmonary diseases. Cell Biol Toxicol. 2025;41:1–31.
- Poljšak B, Jamnik P, Milisav The importance of multifaceted approach for accurate and comprehensive
evaluation of oxidative stress status in biological systems. Antioxidants (Basel). 2025;14:1083.
- Ivanova AV, Kutuzova AD, Kuzmichev IA, Abakumov Alzheimer’s disease: From molecular mechanisms to promising therapeutic strategies. Int J Mol Sci. 2025;26:9444.
- Khan MT, Mohanty S, Devi S, Sharma S, Tripathi P. Dietary flavonoid, gut microbiota, and intestinal diseases: A review with bibliometric trends and research insights. Mol Nutr Food Res. 2026;70:e70368.
- Jain R, Vora L, Nathiya D, Khatri Nrf2–Keap1 pathway and NLRP3 inflammasome in
Parkinson’s disease: Mechanistic crosstalk and therapeutic implications. Mol Neurobiol. 2026;63:91.
- Hafez MH, El-Far AH, Elblehi Astaxanthin alleviates fipronil-induced neuronal damages in male rats through modulating oxidative stress, apoptosis, and inflammatory markers. Sci Rep. 2025;15:14299.
- Li Y, Sun H, Cao D, Guo Y, Wu D, Yang M, et Overcoming biological barriers in cancer therapy: Cell membrane-based nanocarrier strategies for precision delivery. Int J Nanomedicine. 2025:3113–3145.
- Sultana P, Kim YK, Cho SJ, Asadujjaman M, Jee JP. Advances in cell membrane-coated nanoparticles: Multifunctional platforms for targeted drug delivery, precision phototherapy, and enhanced immunotherapy. Biomater Sci. 2025;13:5232–5259.
- Alhowyan AA, Harisa From molecular therapies to lysosomal transplantation and targeted drug strategies: Present applications, limitations, and future prospects of lysosomal medications. Biomolecules. 2025;15:327.
- Bolideei M, Barzigar R, Gahrouei RB, Mohebbi E, Haider KH, Paul S, et al. Applications of gene editing and nanotechnology in stem cell-based therapies for human diseases. Stem Cell Rev Rep. 2025:1–30.
- Alibabaei-Omran F, Javanmehr N, Al-e-Ahmad A, Zabihi E, Najafi T. Viewing decellularized amniotic membrane through the lens of coupled scaffolding and drug delivery systems in regenerative medicine. J Tissue Eng Regen Med. 2025;2025:8818058.

International Journal of Membranes
| Volume | 03 |
| Issue | 01 |
| Received | 01/02/2026 |
| Accepted | 02/02/2026 |
| Published | 20/02/2026 |
| Publication Time | 19 Days |
Login
PlumX Metrics