Controlled Drug Delivery of Furosemides Using Floating Tablet System

Year : 2025 | Volume : 02 | Issue : 01 | Page : 23-31
    By

    Mohd. Wasiullah,

  • Piyush Yadav,

  • Manyata Yadav,

  • Yadav Rahulkumar Ramchandra,

  1. Principal, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  2. Academic Head, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  3. Lecturer, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  4. Scholar, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged gastric retention, providing controlled release and maintaining optimal drug concentration within the absorption site. Key formulation aspects are discussed, including pre-formulation studies to assess drug-excipient compatibility, solubility, flow properties, and buoyancy, which are crucial for floating tablet stability and effectiveness. Various polymers and gas-generating agents are outlined for their roles in achieving buoyancy, improving stability, and controlling drug release. In vitro evaluation methods, such as buoyancy, swelling, and drug release studies, are examined to evaluate the tablet’s performance and release kinetics. Despite challenges like formulation complexity and variability in gastric motility, ongoing research, and optimization in GRDDS for furosemide show promising potential. Prospects in this area could lead to better management of conditions treated with furosemide and improved patient outcomes.

Keywords: Gastroretentative furosemide buoyancy, bioavailability effervescent, Furosemide, Floating tablets, Controlled release.

[This article belongs to International Journal of Membranes ]

How to cite this article:
Mohd. Wasiullah, Piyush Yadav, Manyata Yadav, Yadav Rahulkumar Ramchandra. Controlled Drug Delivery of Furosemides Using Floating Tablet System. International Journal of Membranes. 2025; 02(01):23-31.
How to cite this URL:
Mohd. Wasiullah, Piyush Yadav, Manyata Yadav, Yadav Rahulkumar Ramchandra. Controlled Drug Delivery of Furosemides Using Floating Tablet System. International Journal of Membranes. 2025; 02(01):23-31. Available from: https://journals.stmjournals.com/ijm/article=2025/view=198463


References

  1. Chittam S, Bhosale A. Development and evaluation of floating and expanding gastroretentive film of furosemide. Int J Pharm Investig. 2020;10(2).
  2. Sharma N, Agarwal D, Gupta MK, Khinchi M. A comprehensive review on floating drug delivery system. Int J Res Pharm Biomed Sci. 2011;2(2):428–441.
  3. Ibrahim M, Naguib YW, Sarhan HA, Abdelkader H. Gastro-retentive oral drug delivery systems: A promising approach for narrow absorption window drugs. J Advan Biomed Pharm Sci. 2019;2(3):98–110.
  4. Diós P. Preformulation studies and optimization of floating drug delivery systems based on pharmaceutical technological and biopharmaceutical parameters [Doctorol dissertation]. Pecs: University of Pécs, Faculty of Medicine, Institute of Pharmaceutical Technology and Biopharmacy; 2015.
  5. Naz A, Sadia S, Zama MA, Tarannum SF. Design and evaluation of gastroretentive floating tablets of diuretic furosemide. World J Pharm Res. 2020;9(4):1243–1255.
  6. Prinderre P, Sauzet C, Fuxen C. Advances in gastro retentive drug-delivery systems. Expert Opinion Drug Deliv. 2011;8(9):1189–1203.
  7. Murthy PN, Mahapatra AK, Nayak TK, Dey D. Formulation, characterization and drug release kinetics of floating drug delivery systems. J Chem Pharm Res. 2015;7(6):781–792.
  8. Dixit N. Floating drug delivery system. J Curr Pharm Res. 2011;7(1):6–20.
  9. Gopalakrishnan S, Chenthilnathan A. Floating drug delivery systems: A review. J Pharm Sci Technol. 2011;3(2):548–554.
  10. Hima AVS, Bindu G, Bhavya K, Padmalatha. Floating drug delivery system: An overview. Asian J Res Pharm Sci. 2021;26:295–300.
  11. Karkhile VG, Karmarkar RR, Sontakke MA, Badgujar SD, Nemade LS. Formulation and evaluation of floating tablets of furosemide. Int J Pharm Res Dev. 2010;1:1–9.
  12. Rashmitha V, Madhusudan Rao Y, Pavani S. Formulation and evaluation of fenoverine floating tablets. Asian J Pharm Clin Res. 2021;14(4):175–180.
Regular Issue Subscription Review Article
Volume 02
Issue 01
Received 14/12/2024
Accepted 03/01/2025
Published 09/01/2025
Publication Time 26 Days
Total Visits: 155


My IP

PlumX Metrics