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Safiya Sajid,
- Student, Department of Pharmacy, Prasad Institute of Technology, Jaunpur,, Uttar Pradesh, India
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Bio-inspired membranes in oral drug delivery represent a significant advancement in pharmaceutical technology, harnessing principles of natural biological systems to improve drug permeability, bioavailability, and targeted release. This review discusses the design, materials, and fabrication techniques used in bio-inspired membranes, with a focus on materials like chitosan, silk fibroin, and synthetic polymers that mimic biological structures. By exploring the mechanisms of drug permeation, such as mucoadhesion and selective permeability, bio-inspired membranes demonstrate superior potential to overcome gastrointestinal and enzymatic barriers, enhancing the absorption of challenging drugs. Various applications are highlighted, including systems for chronic disease management and personalized medicine, underscoring the adaptability of bio-inspired membranes to release drugs in a controlled, sustained manner. The review further examines challenges in scaling and regulatory compliance, while emphasizing future research directions and interdisciplinary collaboration to accelerate the clinical translation of these promising systems. Bio-inspired membranes offer a unique solution for advancing oral drug delivery, paving the way for innovative, efficient, and patient-centered therapies
Keywords: Bio-inspired membranes, oral drug delivery, drug permeability, biomaterials, controlled release, mucoadhesion, drug bioavailability, personalized medicine, targeted drug delivery, pharmaceutical innovations
[This article belongs to International Journal of Membranes (ijm)]
Safiya Sajid. Bio-Inspired Membranes in Oral Drug Delivery: A Pathway to Enhanced Permeability and Targeted Therapy. International Journal of Membranes. 2024; 01(02):-.
Safiya Sajid. Bio-Inspired Membranes in Oral Drug Delivery: A Pathway to Enhanced Permeability and Targeted Therapy. International Journal of Membranes. 2024; 01(02):-. Available from: https://journals.stmjournals.com/ijm/article=2024/view=0
References
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- Tibbitt MW, Dahlman JE, Langer R. Emerging frontiers in drug delivery. J Am Chem Soc. 2016 Jan 27;138(3):704–17.
- Al-Dossary AA, Isichei AC, Zhang S, Li J, Errachid A, Elaissari A. Outer membrane vesicles (OMVs) as a platform for vaccination and targeted drug delivery. In: Pharmaceutical Nanobiotechnology for Targeted Therapy. Cham: Springer International Publishing; 2022. p. 1–25.
- Wang S, Gao J, Wang Z. Outer membrane vesicles for vaccination and targeted drug delivery. WIREs Nanomed Nanobiotechnol. 2019 Mar;11(2).
- Tang Y, Varyambath A, Ding Y, Chen B, Huang X, Zhang Y, et al. Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties. Biomater Sci. 2022;10(19):5369–90.
- Loo YS, Bose RJ, McCarthy JR, Azmi ID, Madheswaran T. Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications. Drug Discov Today. 2021 Apr 1;26(4):902–15.
- Wang Y, Lu X, Wu X, Li Y, Tang W, Yang C, et al. Chemically modified DNA nanostructures for drug delivery. The Innovation. 2022 Mar 29;3(2).
- Song W, Zhang M, Huang X, Chen B, Ding Y, Zhang Y, et al. Smart l-borneol-loaded hierarchical hollow polymer nanospheres with antipollution and antibacterial capabilities. Mater Today Chem. 2022 Dec 1;26:101252.
- Zhou Y, Wang M, Yan C, Liu H, Yu DG. Advances in the application of electrospun drug-loaded nanofibers in the treatment of oral ulcers. Biomolecules. 2022 Sep 7;12(9):1254.
- Zhang Y, Liu R, Jin H, Song W, Augustine R, Kim I. Straightforward access to linear and cyclic polypeptides. Commun Chem. 2018 Jul 18;1(1):40.
- Song Z, Han Z, Lv S, Chen C, Chen L, Yin L, et al. Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application. Chem Soc Rev. 2017;46(21):6570–99.
- Silva CO, Sarmento B, Reis CP. Oral delivery of biopharmaceuticals. In: Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies; 2014. p. 125–47.
- Peppas NA, Sahlin JJ. Hydrogels as mucoadhesive and bioadhesive materials: a review. Biomaterials. 1996 Jan 1;17(16):1553–61.
- Jawadi Z, Yang C, Haidar ZS, Santa Maria PL, Massa S. Bio-inspired muco-adhesive polymers for drug delivery applications. Polymers. 2022 Dec 13;14(24):5459.
- Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. Eur J Pharm Biopharm. 2011 Feb 1;77(2):187–99.
- Lohani A, Chaudhary G. Mucoadhesive microspheres: a novel approach to increase gastroretention. Chron Young Sci. 2012 Apr 1;3(2):121.
- Alexander A, Tripathi DK, Verma T, Maurya J, Patel S. Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: a review.
- Carvalho FC, Bruschi ML, Evangelista RC, Gremião MP. Mucoadhesive drug delivery systems. Braz J Pharm Sci. 2010;46:1–7.
- Mahajan P, Kaur A, Aggarwal G, Harikumar SL. Mucoadhesive drug delivery system: a review. Int J Drug Dev Res. 2013 Jan;5(1):11–20.
- Hombach J, Bernkop-Schnürch A. Mucoadhesive drug delivery systems. Drug Deliv. 2010:251–66.
| Volume | 01 |
| Issue | 02 |
| Received | 27/09/2024 |
| Accepted | 29/10/2024 |
| Published | 12/11/2024 |
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