Identification and Characterization of Genetic Predictors of Sickle Cell Anemia in Bilaspur District, Chhattisgarh, India

Open Access

Year : 2026 | Volume : 04 | Issue : 02 | Page : 1 9
    By

    Vandana Kumari,

  • Dowluru S. V. G. K. Kaladhar,

  1. Research Scholar, Department of Microbiology and Bioinformatics, UTD, Atal Bihari Vajpayee University, Bilaspur, Chhattisgarh, India
  2. Professor, Department of Microbiology and Bioinformatics, UTD, Atal Bihari Vajpayee University, Bilaspur, Chhattisgarh, India

Abstract

In the present decades, sickle cell anemia (SCA) is a challenging task for control of hereditary syndrome in Bilaspur district of Chhattisgarh state, India. The present study aims to identify and characterize genetic predictors of SCA from Bilaspur district (CG) in 2024. A total of 3000+ individuals were screened and categorized into carriers, positive (screening), and diseased cases. Fetal hemoglobin (HbF) level is determined by several genetic factors including genetic variation of BLC11A, HBS1L-MYB, ITGA1, RUNX1T1 and HBG2 genes. The results indicate a high prevalence of sickle cell carriers among females, and paediatric populations.

Keywords: Sickle cell anemia, data, carrier frequency, Bilaspur, Chhattisgarh

[This article belongs to International Journal of Genetic Modifications and Recombinations ]

How to cite this article:
Vandana Kumari, Dowluru S. V. G. K. Kaladhar. Identification and Characterization of Genetic Predictors of Sickle Cell Anemia in Bilaspur District, Chhattisgarh, India. International Journal of Genetic Modifications and Recombinations. 2026; 04(02):1-9.
How to cite this URL:
Vandana Kumari, Dowluru S. V. G. K. Kaladhar. Identification and Characterization of Genetic Predictors of Sickle Cell Anemia in Bilaspur District, Chhattisgarh, India. International Journal of Genetic Modifications and Recombinations. 2026; 04(02):1-9. Available from: https://journals.stmjournals.com/ijgmr/article=2026/view=245381


References

1. Mansour AK, Yahia S, El-Ashry R, Alwakeel A, Darwish A, Alrjjal K. Sickle cell disease (SCD). In: Inherited Hemoglobin Disorders. 2015 Nov 11;35.

2. Obeagu EI, Adias TC, Obeagu GU. Advancing life: Innovative approaches to enhance survival in sickle cell anemia patients. Ann Med Surg. 2024 Oct;86(10):6021–36.

3. Kavanagh PL, Fasipe TA, Wun T. Sickle cell disease: A review. JAMA. 2022 Jul 5;328(1):57–68.

4. Ben Hamda C, Sangeda R, Mwita L, Meintjes A, Nkya S, Panji S, et al. A common molecular signature of patients with sickle cell disease revealed by microarray meta-analysis and a genome-wide association study. PLoS One. 2018 Jul 6;13(7):e0199461.

5. Fitzsimmons R, Amin N, Uversky VN. Understanding the roles of intrinsic disorder in subunits of hemoglobin and the disease process of sickle cell anemia. Intrinsically Disord Proteins. 2016;4(1):e1248273.

6. Serjeant GR. Sickle cell disease. Assoc Gen Pract Jamaica Newsl. 1984:20–9.

7. Tebbi CK. Sickle cell disease, a review. Hemato. 2022 May 30;3(2):341–66.

8. Ranney HM, Sharma VI. Structure and function of hemoglobin. In: Williams’s Hematology. 6th ed. New York: McGraw Hill; 2000. p.345–53.

9. Venkatesan V, Srinivasan S, Babu P, Thangavel S. Manipulation of developmental gamma-globin gene expression: an approach for healing hemoglobinopathies. American Society for Microbiology Mol Cell Biol. 2021;41(1):e00253-20. doi: 10.1128/MCB.00253-20.

10. Sahu S, Gautam RK. Socio-Demographic and Related Indicators of Underwent Hysterectomy: A Cross-Sectional Study Conducted among the Women of District Bilaspur (CG), India.

11. Karri B, Mathew GS. A comparative analysis of reproductive measures and predictor variables among three tribes of Bilaspur, Chhattisgarh, India. Cogent Soc Sci. 2022;8(1):2106649.

12. Josephson CD, Su LL, Hillyer KL, Hillyer CD. Transfusion in the patient with sickle cell disease: A critical review of the literature and transfusion guidelines. Transfus Med Rev. 2007 Apr;21(2):118–33.


Regular Issue Open Access Original Research
Volume 04
Issue 02
Received 27/04/2026
Accepted 11/05/2026
Published 20/05/2026
Publication Time 23 Days


Login


My IP

PlumX Metrics