Innovative Antifungal strategies: Terbinafine hydrochloride in Niosomal carriers

Year : 2025 | Volume : 02 | Issue : 02 | Page : 1 16
    By

    Shraddha Bandgar,

  • Raju Rathod,

  • Vivekanand Teli,

  • Pankaj Jadhav,

  1. Lecturer, Department of Pharmaceutics, Dr. Shivajirao Kadam College of Pharmacy, Kasabe Digraj, Sangli, Maharashtra, India
  2. Assistant Professor, Department of Pharmaceutics, Shree Ambabai Talim Sanstha’s Diploma In Pharmacy College, Miraj, Maharashtra, India
  3. Assistant Professor, Department of Pharmaceutical chemistry, Riyajbhai Shamanji College of Pharmacy, Gadhinglaj, Maharashtra, India
  4. Associate Professor, Department of Pharmaceutics, Dr. Shivajirao Kadam College of Pharmacy, Kasabe Digraj, Sangli,, Maharashtra, India

Abstract

Onychomycosis, an infection caused by fungi that affects fingernails or toenails, causes the nails to grow, separate from the nail bed, and become discoloured. While anybody can get, those with weakened immune systems, children and the elderly are especially susceptible.  Present study was related to formulate an effective nail lacquer that would treat onychomycosis by utilizing Terbinafine hydrochloride. In this study, niosomes of a medication called terbinafine hydrochloride, an antifungal drug, were mixed in Nitrocellulose or Eudragit RL 100, a well-known polymer. Nail lacquer is created by simple mixing procedure. The frequency of application was reduced for twice per week by utilizing polymers like nitro cellulose, to maintain the release of drug for a whole day. Infection is characterized by discomfort as well as swelling surrounding the nail, as well as an unpleasant smell. Therefore, ethyl acetate will help to disguise the disagreeable smell and also have an anti-inflammatory effect to improve patient acceptability and compliance. Oleic acid serves as a penetration enhancer, boosting the medicament’s capacity to enter into the nail bed. When improving the formulation, factors including water resistance testing, drying time and non-volatile content were taken into account. For the optimized formulation, the optimal drying time was 2 minutes. Consequently, niosomal nail lacquer containing Terbinafine hydrochloride was successfully produced.

Keywords: Terbinafine hydrochloride, Nitro cellulose, Niosomal nails lacquer, Onychomycosis, hyperkeratosis.

[This article belongs to International Journal of Fungi ]

How to cite this article:
Shraddha Bandgar, Raju Rathod, Vivekanand Teli, Pankaj Jadhav. Innovative Antifungal strategies: Terbinafine hydrochloride in Niosomal carriers. International Journal of Fungi. 2025; 02(02):1-16.
How to cite this URL:
Shraddha Bandgar, Raju Rathod, Vivekanand Teli, Pankaj Jadhav. Innovative Antifungal strategies: Terbinafine hydrochloride in Niosomal carriers. International Journal of Fungi. 2025; 02(02):1-16. Available from: https://journals.stmjournals.com/ijf/article=2025/view=222077


References

  1. Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Aravind G, Kumar KS. Nail drug delivery system-a novel approaches for drug delivery system. The pharma innovation. 2013;1(11, Part A):3.
  2. Saner MV, Kulkarni AD, Pardeshi CV. Insights into drug delivery across the nail plate barrier. Journal of drug targeting. 2014 Nov 1;22(9):769-89.
  3. Murdan S. Enhancing the nail permeability of topically applied drugs. Expert opinion on drug delivery. 2008 Nov 1;5(11):1267-82.
  4. Šveikauskaitė I, Briedis V. Effect of film-forming polymers on release of naftifine hydrochloride from nail lacquers. International Journal of Polymer Science. 2017 Feb 16;2017.
  5. Vikas A, Rashmin P, Mrunali P, Chavan RB, Kaushik T. Mechanistic insights of formulation approaches for the treatment of nail infection: conventional and novel drug delivery approaches. AAPS PharmSciTech. 2020 Feb; 21:1-2.
  6. Jan S, Bora D, Bhise K. Preungual drug delivery systems of terbinafine hydrochloride nail lacquer. Asian Journal of Pharmaceutics (AJP). 2008;2(1).
  7. Ravalika V, Sailaja AK. Formulation and evaluation of etoricoxib niosomes by thin film hydration technique and ether injection method. Nano Biomed Eng. 2017 Sep 1;9(3):242-8.
  8. Morteza-Semnani K, Saeedi M, Akbari J, Hedayati S, Hashemi SM, Rahimnia SM, Babaei A, Ghazanfari M, Haghani I, Hedayati MT. Green formulation, characterization, antifungal and biological safety evaluation of terbinafine HCl niosomes and niosomal gels manufactured by eco-friendly green method. Journal of Biomaterials Science, Polymer Edition. 2022 Nov 23;33(18):2325-52.
  9. Marty JP. Amorolfine nail lacquer: a novel formulation. Journal of the European Academy of Dermatology and Venereology. 1995 Apr 1;4:S17-21.
  10. Shirwaikar AA, Thomas T, Shirwaikar A, Lobo R, Prabhu KS. Treatment of onychomycosis: an update. Indian journal of pharmaceutical sciences. 2008 Nov;70(6):710.
  11. Salve PS. Development and evaluation of topical drug delivery system for terbinafine hydrochloride using niosomes. Research Journal of Topical and Cosmetic Sciences. 2011;2(2):52-63.
  12. Shi H, Xie Y. Solubility and thermodynamics of terbinafine hydrochloride in different neat and binary solvents: Measurement, correlation and molecular interactions. Journal of Molecular Liquids. 2017 Oct 1; 243:293-301.
  13. Thavva VE, Baratam SR. Formulation and evaluation of terbinafine hydrochloride microsponge gel. Int J Appl Pharm. 2019 Nov 7;11(6):78-85.
  14. Bargir TN, Aj AD, Sa PA. Composition of terbinafine HCL polymeric gel for mucosal drug delivery. IJBPAS. 2016;5(9):2146-68.
  15. Van Dooren AA, Müller BW. Purity determinations of drugs with differential scanning calorimetry (DSC)—a critical review. International journal of pharmaceutics. 1984 Jul 1;20(3):217-33.
  16. Kuminek G, Rauber GS, Riekes MK, de Campos CE, Monti GA, Bortoluzzi AJ, Cuffini SL, Cardoso SG. Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride. Journal of pharmaceutical and biomedical analysis. 2013 May 5;78:105-11.
  17. Atici EB, Karlığa B. Quantitative determination of two polymorphic forms of imatinib mesylate in a drug substance and tablet formulation by X-ray powder diffraction, differential scanning calorimetry and attenuated total reflectance Fourier transform infrared spectroscopy. Journal of pharmaceutical and biomedical analysis. 2015 Oct 10;114:330-40.
  18. Gunst RF, Mason RL. Fractional factorial design. Wiley Interdisciplinary Reviews: Computational Statistics. 2009 Sep;1(2):234-44.
  19. Olii AT, Nugroho AK, Martien R, Riyanto S. Effect of Ratio Span 60-Cholesterol on the Characteristic of Niosomes Vitamin D3. Research Journal of Pharmacy and Technology. 2022;15(12):5551-4.
  20. Nowroozi F, Almasi A, Javidi J, Haeri A, Dadashzadeh S. Effect of surfactant type, cholesterol content and various downsizing methods on the particle size of niosomes. Iranian journal of pharmaceutical Research: IJPR. 2018;17(Suppl2):1.
  21. Lv Y, He H, Qi J, Lu Y, Zhao W, Dong X, Wu W. Visual validation of the measurement of entrapment efficiency of drug nanocarriers. International journal of pharmaceutics. 2018 Aug 25;547(1-2):395-403.
  22. Nordström R, Zhu L, Härmark J, Levi-Kalisman Y, Koren E, Barenholz Y, Levinton G, Shamrakov D. Quantitative cryo-TEM reveals new structural details of doxil-like PEGylated liposomal doxorubicin formulation. Pharmaceutics. 2021 Jan 19;13(1):123.
  23. Puri, V.; Savla, R.; Chen, K.; Robinson, K.; Virani, A.; Michniak-Kohn, B. Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate. Pharmaceutics 2022, 14, 2204. https://doi.org/10.3390/ pharmaceutics14102204
  24. Aggarwal R, Targhotra M, Sahoo PK, Chauhan MK. Efinaconazole nail lacquer for the transungual drug delivery: Formulation, optimization, characterization and in vitro evaluation. Journal of Drug Delivery Science and Technology. 2020 Dec 1;60:101998.
  25. Thatai P, Sapra B. Terbinafine hydrochloride nail lacquer for the management of onychomycosis: formulation, characterization and in vitro evaluation. Therapeutic Delivery. 2018 Feb;9(2):99-119.
  26. Mehta SK, Jindal N, Kaur G. Quantitative investigation, stability and in vitro release studies of anti-TB drugs in Triton niosomes. Colloids and Surfaces B: Biointerfaces. 2011 Oct 1;87(1):173-9.
  27. Singh CH, Jain CP, Kumar BN. Formulation, characterization, stability and invitro evaluation of nimesulide niosomes. Pharmacophore. 2011;2(3-2011):131-48.
  28. Thavva VE, Baratam SR. Formulation and evaluation of terbinafine hydrochloride microsponge gel. Int J Appl Pharm. 2019 Nov 7;11(6):78-85.
  29. Valdes BS, Serro AP, Gordo PM, Silva A, Gonçalves L, Salgado A, Marto J, Baltazar D, Dos Santos RG, Bordado JM, Ribeiro HM. New polyurethane nail lacquers for the delivery of terbinafine: formulation and antifungal activity evaluation. Journal of Pharmaceutical Sciences. 2017 Jun 1;106(6):1570-7.
  30. Ceren Ertekin Z, Sezgin Bayindir Z, Yuksel N. Stability studies on piroxicam encapsulated niosomes. Current drug delivery. 2015 Apr 1;12(2):192-9
Regular Issue Subscription Review Article
Volume 02
Issue 02
Received 14/03/2025
Accepted 13/07/2025
Published 28/07/2025
Publication Time 136 Days
176

Login


My IP

PlumX Metrics