Edible Mushrooms: Management of Diabetes Mellitus and Phytochemical Screening of Agaricus Bisporus

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Year : 2025 | Volume : 03 | Issue : 01 | Page : –
    By

    Varun Mishra,

  • Sarbjot Singh,

  • Rajneesh Kaur,

  • Brij Bhushan,

  • Shruti Jaswal,

  • Anita Devi,

  • Anuneet Kaur,

Abstract

A metabolic disease characterized by elevated blood glucose levels, diabetes mellitus affects millions of people. If not treated on time, it cause problems, damage organs, and even life-threatening. Studies have shown that diabetes can be avoided and controlled with a healthy lifestyle that incorporates exercise and a balanced diet. While there are several synthetic medications available to treat this illness using them over an extended period of time is linked to a number of negative effects. As a result, researchers are paying more attention to medicinal plants and herbs since they are seen as a safer option. Edible mushrooms are a type of plant-based therapy that may help with diabetes. They are rich in natural compounds like fibers, polysaccharides, phenolics, and alkaloids and have long been known for their anti-diabetic, antioxidant, and cholesterol-lowering properties. The carbohydrates in mushrooms act as prebiotics, helping to change gut bacteria composition and reduce insulin resistance. The etiology of diabetes is covered in this review, along with an explanation of a few possible mushroom species with anti-hyperglycemic properties. It has also been studied how various polysaccharides found in mushrooms affect the composition of gut macrobiotic in animal models of diabetes.

Keywords: Metabolic, Mushrooms, Diabetes mellitus, T cells, β-cells, cellular processes

[This article belongs to International Journal of Cell Biology and Cellular Functions ]

How to cite this article:
Varun Mishra, Sarbjot Singh, Rajneesh Kaur, Brij Bhushan, Shruti Jaswal, Anita Devi, Anuneet Kaur. Edible Mushrooms: Management of Diabetes Mellitus and Phytochemical Screening of Agaricus Bisporus. International Journal of Cell Biology and Cellular Functions. 2025; 03(01):-.
How to cite this URL:
Varun Mishra, Sarbjot Singh, Rajneesh Kaur, Brij Bhushan, Shruti Jaswal, Anita Devi, Anuneet Kaur. Edible Mushrooms: Management of Diabetes Mellitus and Phytochemical Screening of Agaricus Bisporus. International Journal of Cell Biology and Cellular Functions. 2025; 03(01):-. Available from: https://journals.stmjournals.com/ijcbcf/article=2025/view=203246



References

  1. Kumar A, Goel MK, Jain RB, Khanna P, Chaudhary V. India towards diabetes control: Key issues. Australasian Med J. 2013;6:524–31.
  1. Bordoloi R, Dutta KN. A review on herbs used in the treatment of diabetes mellitus. J Pharm Chem Biol Sci. 2014;2:86–92.
  1. Vision 2020 UK. IDF Diabetes Atlas, 7th Edition. Available from: http://www.vision2020uk.org.uk/idfdiabetes-atlas-7thedition
  1. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: Prevalence, numerical estimates, and projections. Diabetes Care. 1998;21:1414–31.
  1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.
  1. Ozkum D, Akı O, Toklu HZ. Herbal medicine use among diabetes mellitus patients in Northern Cyprus. J Med Plant Res. 2013;7:1652–64.
  1. Recent TP. Trends in therapeutic approaches for diabetes management: A comprehensive update. J Diabetes Res. 2015;11.
  1. Health and Social Care Information Centre (HSCIC). National Diabetes Foot Care Audit report 2014-2015. Report, England and Wales, March 2016.
  1. Narayan DS, Patra VJ, Dinda SC. Diabetes and Indian traditional medicines: An overview. Int J Pharm Pharm Sci. 2012;4.
  1. Kumari MS, Lakshmi KN, Prasanna TVVNL, Swapna K, Jyothi AS, Prasanth T. Natural herbs vs allopathic drugs: To treat diabetes. Indo Am J Pharm Sci. 2016;3:415–22.
  1. Kerr M, Rayman G, Jeffcoate WJ. Cost of diabetic foot disease to the National Health Service in England. Diabet Med. 2014;31:1498–504.
  1. Prabhakar PK, Doble M. Mechanism of action of natural products used in the treatment of diabetes mellitus. Chin J Integr Med. 2011;17.
  1. Boulton AJ. The pathway to foot ulceration in diabetes. Med Clin North Am. 2013;97:775–90.
  1. DeFronzo RA, Bonadonna RC, Ferrannini E, Zimmet P. Pathogenesis of NIDDM. In: International Textbook of Diabetes Mellitus. 1997. p. 635-712.
  1. Poudel A, Savari O, Striegel DA, Periwal V, Taxy J, Millis JM, et al. Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes. Endocrine. 2015;49:693–702.
  1. Wojcik JL, Devassy JG, Wu Y, Zahradka P, Taylor CG, Aukema HM. Protein source in a high-protein diet modulates reductions in insulin resistance and hepatic steatosis in fa/fa Zucker rats. Obesity (Silver Spring). 2016;24:123–31.
  1. Triplitt C, Solis-Herrera C, Cersosimo E, Abdul-Ghani M, Defronzo RA. Empagliflozin and linagliptin combination therapy for treatment of patients with type 2 diabetes mellitus. Expert Opin Pharmacother. 2015;16:2819–33. Fukuoka Y, Choi J, Gonzalez SB, Arai S. Family history and body mass index predict perceived risks of diabetes and heart attack among community-dwelling Caucasian, Filipino, Korean, and Latino Americans–DiLH survey. Diabetes Res Clin Pract. 2015;109:157–63.
  2. Chawla A, Chawla R, Jaggi S. Microvascular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian J Endocrinol Metab. 2016;20:546–51.
  3. Tripathi KD. Essentials of Medical Pharmacology. 7th ed. New Delhi: Jaypee Brothers Medical Publisher; 2013. p. 258-281.
  4. Harris MI. Undiagnosed NIDDM, clinical and public health issues. Diabetes Care. 1993;16:642-52.
  5. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, et al. Predicting type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes. 1996;45:926-33.
  6. Ahmad N, Bansal R, Rastogi AK, Kidwai JR. Effect of PHA-B fraction of Agaricus bisporus lectin on insulin release and 45Ca2+ uptake by islets of Langerhans in vitro. Acta Diabetol Lat. 1984;21:63–70. doi: 10.1007/BF02582088.
  7. Obodai M, Narh Mensah DL, Fernandes Â, Kortei NK, Dzomeku M, Teegarden M, Schwartz SJ, Barros L, Prempeh J, Takli RK, et al. Chemical characterization and antioxidant potential of wild Ganoderma species from Ghana. Molecules. 2017;22:196. doi: 10.3390/molecules22020196.
  8. Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH. A double-blind, randomized, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome. Sci Rep. 2016;6:29540. doi: 10.1038/srep29540.
  9. Li J, Cai C, Zheng M, Hao J, Wang Y, Hu M, Fan L, Yu G. Alkaline extraction, structural characterization, and bioactivities of (1→6)-β-d-glucan from Lentinus edodes. Molecules. 2019;24:1610. doi: 10.3390/molecules24081610.
  10. De Silva DD, Rapior S, Hyde KD, Bahkali AH. Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Divers. 2012;56:1–29. doi: 10.1007/s13225-012-0187-4.
  11. Firenzuoli F, Gori L, Lombardo G. The medicinal mushroom Agaricus blazei Murrill: Review of literature and pharmaco-toxicological problems. Evid Based Complement Altern Med. 2008;5:3–15. doi: 10.1093/ecam/nem007.
  12. Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N. Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J Diabetes. 2017;8:187. doi: 10.4239/wjd.v8.i5.187.
  13. Lei H, Guo S, Han J, Wang Q, Zhang X, Wu W. Hypoglycemic and hypolipidemic activities of MT-α-glucan and its effect on immune function of diabetic mice. Carbohydr Polym. 2012;89:245–50. doi: 10.1016/j.carbpol.2012.03.003.
  14. Khan MA, Tania M. Nutritional and medicinal importance of Pleurotus mushrooms: An overview. Food Rev Int. 2012;28:313–29. doi: 10.1080/87559129.2011.637267.
  15. Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: Improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi: 10.1155/2015/376387.
  16. Royse DJ. A global perspective on the high five: Agaricus, Pleurotus. Proceedings of the International Conference on Mushroom Biology and Mushroom Products, New Delhi, India; 2014 Nov 19–22. p. 2010–15.
  17. De Silva DD, Rapior S, Fons F, Bahkali AH, Hyde KD. Medicinal mushrooms in supportive cancer therapies: An approach to anti-cancer effects and putative mechanisms of action – A review. Fungal Divers. 2012;55:1–35.
  18. Chaturvedi VK, Singh A, Dubey SK, Hetta HF, John J, Singh MP. Molecular mechanistic insight of hepatitis B virus mediated hepatocellular carcinoma. Microb Pathol. 2019;128:184–94.
  19. Agarwal S, Vaseem H, Kushwaha A, Gupta KK, Maurya S, Chaturvedi VK, Pathak RK, Singh MP. Yield, biological efficiency and nutritional value of Pleurotus sajor-caju cultivated on floral and agro-waste. Cell Mol Biol. 2016;62:1–5.
  20. Cai M, Lin Y, Luo YL, et al. Extraction, antimicrobial, and antioxidant activities of crude polysaccharides from the wood ear medicinal mushroom Auricularia auricular-judae (higher basidiomycetes). Int J Med Mushrooms. 2015;17:591–600.
  21. Syafrizal, Ramadhan R, Kusuma IW, Egra S, Shimizu K, Kanzaki M, Arung ET. Diversity and honey properties of stingless bees from meliponiculture in East and North Kalimantan, Indonesia. Biodiversitas. 2020;21(10):4623–30. doi: 10.13057/biodiv/d211021.
  22. Obafemi TO, Onasanya A, Adeoye A, Falode JA, Daniel DJ, Irefo EF, Ojo AO, Fadaka A, Afolabi OB, Awe JO, Omiyale BO. Journal of Applied Pharmaceutical Science. 2019;9(5):065-72.
  23. Lavi I, Levinson D, Peri I, Tekoah Y, Hadar Y, Schwartz B. Cancer Lett. 2010;85:1977-90.
  24. Du M, Huang S, Zhang J, Wang J, Hu L, Jiang J. Open Journal of Forestry. 2015.
  25. Kozarski M, Klaus A, Vunduk J, Zizak Z, Niksic M, Jakovljevic D, Vrvic MM, Van Griensven LJLD. Nutraceutical properties of the methanolic extract of edible mushroom Cantharellus cibarius (Fries): Primary mechanisms. Food Funct. 2015;6:1875–86. doi: 10.1039/C5FO00312A.
  26. Klaus A, Kozarski M, Niksic M, Jakovljevic D, Todorovic N, Van Griensven LJLD. Antioxidative activities and chemical characterization of polysaccharides extracted from the basidiomycete Schizophyllum commune. LWT Food Sci Technol. 2011;44:2005–11. doi: 10.1016/j.lwt.2011.05.010.
  27. Ayeka PA. Potential of mushroom compounds as immunomodulators in cancer immunotherapy: A review. Evid Based Complement Altern Med. 2018;2018:7271509. doi: 10.1155/2018/7271509.
  28. Chen J, Seviour R. Medicinal importance of fungal beta-(1→3), (1→6)-glucans. Pt 6. Mycol Res. 2007;111:635–52. doi: 10.1016/j.mycres.2007.02.011.
  29. Badalyan S. Edible Ectomycorrhizal Mushrooms. Berlin, Germany: Springer; 2012. Medicinal aspects of edible ectomycorrhizal mushrooms. p. 317–34.
  30. Guillamón E, García-Lafuente A, Lozano M, D´ Arrigo M, Rostagno MA, Villares A, Martínez JA. Edible mushrooms: Role in the prevention of cardiovascular diseases. Fitoterapia. 2010;81(7):715–23. doi: 10.1016/j.fitote.2010.06.005.
  31. Dugler B, Gonuz A, Gucin F. Antimicrobial activity of the macrofungus Cantharellus cibarius. Pakistan J Biol Sci. 2004;7:1535–39.
  32. Ajit TA, Janardhana KK. Indian medicinal mushrooms as a source of antioxidant and antitumor agents. J Clin Biochem Nutr. 2007;40:157–62.
  33. Rahi DK, Malik D. Diversity of mushrooms and their metabolites of nutraceutical and therapeutic significance. J Mycol. 2016;2016:1–18.
  34. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70. doi: 10.1016/S0092-8674(00)81683-9.
  35. Behera BC, Verma N, Sonone A, Makhija U. Antioxidant and antibacterial activities of lichen Usnea ghattensis in vitro. Biotechnol Lett. 2005;27:991–95.
  36. Zhou CY, Jia W, Yang Y, Bai YQ. Experimental studies on prevention of several kinds of fungi polysaccharides against alcohol-induced hepatic injury. Edible Fungi. 2002;24:36–37.
  37. Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: Improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi: 10.1155/2015/376387.
Regular Issue Subscription Original Research
Volume 03
Issue 01
Received 06/03/2025
Accepted 08/03/2025
Published 10/03/2025
Publication Time 4 Days
Total Visits: 31


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