Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta Analysis

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Year : 2025 | Volume : 03 | Issue : 01 | Page : –
    By

    Mohammad Nadeem Khan,

  1. Assistant Professor, Senior Clinical Research Coordinator, Department of Pharmacology (Clinical Pharmacology), Sri Aurobindo Medical College &PG Institute, Sri Aurobindo University, Indore, Madhya Pradesh, India

Abstract

Background Non-enzymatic glycation, where reducing sugars react with proteins, lipids, and nucleic acids, contributes to various pathological conditions such as diabetic complications and cardiovascular diseases. This process is facilitated by the receptor for advanced glycation end-products (RAGE), which is pivotal in driving inflammation and causing tissue damage.Objective This meta-analysis evaluates the effects of plant-derived phytochemicals on RAGE expression and associated signaling pathways, assessing their therapeutic potential in glycation-related diseases.Methods A systematic search identified 26 studies, including in vitro (n = 16) and animal models (n = 10). Statistical analysis was performed using standardized mean difference (SMD) to assess the impact of different phytochemicals on RAGE expression, with subgroup analyses by phytochemical type and experimental model.Findings Results showed that flavonoids (e.g., quercetin and apigenin) had the most significant effects in reducing RAGE expression (SMD = -1.20), followed by polyphenols like resveratrol and curcumin (SMD = -0.70 to -0.85). Animal models exhibited greater efficacy in reducing RAGE expression compared to in vitro studies. These findings highlight the therapeutic potential of these compounds for managing diabetic nephropathy, cardiovascular diseases, and other glycation-related conditions.Conclusion Plant-derived phytochemicals, particularly flavonoids and polyphenols, show promise as therapeutic agents targeting RAGE expression. Future research should focus on clinical trials, bioavailability, combination therapies, and personalized medicine to optimize their use in treating glycation-related diseases.

Keywords: Non-enzymatic glycation, receptor for advanced glycation end-products (RAGE), phytochemicals, flavonoids, polyphenols, quercetin, resveratrol, curcumin, glycation-related diseases, diabetic nephropathy,

[This article belongs to International Journal of Cell Biology and Cellular Functions ]

How to cite this article:
Mohammad Nadeem Khan. Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta Analysis. International Journal of Cell Biology and Cellular Functions. 2025; 03(01):-.
How to cite this URL:
Mohammad Nadeem Khan. Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta Analysis. International Journal of Cell Biology and Cellular Functions. 2025; 03(01):-. Available from: https://journals.stmjournals.com/ijcbcf/article=2025/view=203241



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Regular Issue Subscription Original Research
Volume 03
Issue 01
Received 27/12/2024
Accepted 08/01/2025
Published 10/03/2025
Publication Time 73 Days
Total Visits: 34


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