Nicky Jaiswal,
Kabhi Khanna,
Shah Samreen,
Km Priyanka Singh,
Rifat Siraj,
- Assistant professor, Department of Pharmacy, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh Punjab, India
- Student, Department of Pharmacy, Adesh institute of Pharmacy and Biomedical Science, Adesh University, Bathinda Punjab, India
- Student, Department of Pharmacy, Adesh institute of Pharmacy and Biomedical Science, Adesh University, Bathinda Punjab, India
- Student, Department of Dental Sciences, Adesh institute of Dental Science and research, Adesh University, Bathinda Punjab, India
- Student, Department of Dental Sciences, Adesh institute of Dental Science and research, Adesh University, Bathinda Punjab, India
Abstract
Psychiatric health problems are also a large burden on global health and existing psychotropic drugs may be restricted by relative effectiveness, side effects, and inadequate long-term tolerability. Plant- based psychotropic agents have subsequently been the focus of interest in the form of complementary or alternative therapies. This review outlines the pharmacognostic, mechanisms of action and therapeutic importance of plant-based psychotropic agents against central neurotransmitter systems. The traditional medicinal practices give a lot of information on how botanicals can be used to treat mood disorders, mental anxiety, insomnia and intellectual incapacity. Preclinical evidence reveals that phytochemicals including alkaloids, flavonoids, terpenoids and phenolic compounds regulate serotonergic, dopaminergic, GABAergic and glutamatergic systems and also have neuroprotective and anti-inflammatory effects. The new clinical evidence shows some promise in psychiatric conditions of mild to moderate severity with relatively positive safety and tolerability rates. Nevertheless, issues associated with standardization, dose optimization, herb–drug interactions, and translation restrictions remain. Strict research and clinical validation could help to solve these problems and allow incorporating plant-derived psychotropic agents into the realm of the contemporary psychiatry.
Keywords: Medicinal plants, Neurotransmitter systems, Pharmacognosy, Phytochemicals, Plant- derived psychotropic agents
[This article belongs to International Journal of Brain Sciences ]
Nicky Jaiswal, Kabhi Khanna, Shah Samreen, Km Priyanka Singh, Rifat Siraj. Plant-Derived Psychotropic Agents Targeting Neurotransmitter Systems: Pharmacognostic Evidence, Mechanisms, and Clinical Relevance. International Journal of Brain Sciences. 2026; 03(01):34-42.
Nicky Jaiswal, Kabhi Khanna, Shah Samreen, Km Priyanka Singh, Rifat Siraj. Plant-Derived Psychotropic Agents Targeting Neurotransmitter Systems: Pharmacognostic Evidence, Mechanisms, and Clinical Relevance. International Journal of Brain Sciences. 2026; 03(01):34-42. Available from: https://journals.stmjournals.com/ijbs/article=2026/view=237772
References
1. Darabi F, Najafi Z, Arvan K, Mohammadi N, Shadmani FK, Soltani S. Quality of life among people with disabilities and its related factors in Iran: a cross-sectional study. BMC Public Health. 2025;25(1):2967. 2. Żółtaszek A. Mental and occupational difficulties of vulnerable groups in the labour force: women, young and older workers, demographic and sexual minorities, and people with disabilities. Employ Respons Rights J. 2025. 3. Borrego-Ruiz A, Borrego JJ. Plant-derived nutraceuticals in mental health and brain function: mechanisms of action and therapeutic potential. Int J Mol Sci. 2025;26(18):8849. 4. Carmellini P, Cuomo A, Rescalli MB, Fagiolini A. GLP-1 receptor agonists in mood disorders: a psychiatric perspective. Life. 2025;15(9):1422. 5. Qi X. Neuropharmacology of neurotransmitter systems: current drugs and their effects on neural and neuroendocrine pathways. Asia Pac J Clin Med Res. 2025;1(1). 6. Kumar D, Singh R, Mishra AK. Neurotransmitter modulation and cognitive enhancement. In: Jahan S, Siddiqui AJ, Khan A, editors. A mechanistic exploration of natural compounds for neuronal health. Singapore: Springer Nature Singapore; 2025. p. 109-142. 7. Unal ED. Phytomedicine interventions in mental health: mechanisms and implications. In: Mohamed W, Özge A, editors. Feeding the mind: the connection between diet, drugs, and mental health. Vol 2, Innovations and specialized approaches in nutritional neuroscience. Singapore: Springer Nature Singapore; 2025. p. 173-205. 8. Rigillo G, Blom JMC, Cocchi A, Martinucci V, Favaro F, Baini G, et al. Medicinal plants for child mental health: clinical insights, active compounds, and perspectives for rational use. Children (Basel). 2025;12(9):1142. 9. Balkrishna A, Agarwal U, Arya D, Chaudhary S, Arya V. From tradition to evidence: exploring the neurochemical basis of medicinal plants in anxiety therapy. World J Biol Psychiatry. 2025;26(8):371-408. 10. Naoi M, Wu Y, Maruyama W, Shamoto-Nagai M. Phytochemicals modulate biosynthesis and function of serotonin, dopamine, and norepinephrine for treatment of monoamine neurotransmission-related psychiatric diseases. Int J Mol Sci. 2025;26(7):2916. 11. Chintada V, Golla N. Exploring the therapeutic potential of bioactive compounds from plant sources. In: Devi J, editor. Biotechnological intervention in production of bioactive compounds: biosynthesis, characterization and applications. Cham: Springer Nature Switzerland; 2025. p. 229-247. 12. Sun Y, Hasbi A, George SR. G protein–coupled receptor heteromers in the brain: functional and therapeutic importance in neuropsychiatric disorders. Annu Rev Pharmacol Toxicol. 2025;65:215-236. 13. Sapienza J, Martini F, Comai S, Cavallaro R, Spangaro M, De Gregorio D, et al. Psychedelics and schizophrenia: a double-edged sword. Mol Psychiatry. 2025;30(2):679-692. 14. Nikbakhtzadeh M, Bordbar S, Seyedi S, Ranjbaran M, Ashabi G, Kheradmand A. Significance of neurotransmitters in cerebral ischemia: understanding the role of serotonin, dopamine, glutamate, and GABA in stroke recovery and treatment. CNS Agents Med Chem. 2025;25(3):211-229. 15. Gholami A, Mortezaee K. Neurotransmitters in neural circuits and neurological diseases. ACS Chem Neurosci. 2025;16(19):3653-3664. 16. Singh S, Kar A, Samantray S. Comprehensive guide to mental health: stress, therapies and trends. 2025. 17. Satapathy T, Sen K. Plant-based dietary supplements: an overview. In: Mukherjee B, editor. Dietary supplements and nutraceuticals. Singapore: Springer Nature Singapore; 2025. p. 39-88. 18. Bülbül EÖ, Okur NÜ. Difficulties in using natural herbal substances and their current use in some pharmaceutical dosage forms. Curr Pharm Des. 2025;31(28):2252-2266. 19. Mohite P, Puri A. Adulteration and evaluation of crude drugs of natural origin. In: Pharmacognosy and phytochemistry. 2025. p. 101-121. 20. Vanhee C, Deconinck E, George M, Hansen A, Hackl A, Wollein U, et al. The occurrence of illicit smart drugs or nootropics in Europe and Australia and their associated dangers: results from a market surveillance study by twelve official medicines control laboratories. J Xenobiot. 2025;15(3):88. 21. Sethi SS, Bhardwaj T, Sethi SK, Kaur S, Rimpi, Baldi A. Advancing herbal medicine safety: the need for a global pharmacovigilance approach. Naunyn Schmiedebergs Arch Pharmacol. 2025;398(10):13499-13514. 22. Karthikeyan M, Mehta A, Kumar SS, Mohan H, Usha B. Safety, dosage, and regulatory aspects in the use of phytochemicals. In: Kuca K, Patocka J, Kumar V, Dhalaria R, editors. Medicinal plants and their bioactives in human diseases. Cham: Springer Nature Switzerland; 2025. p. 207-233. 23. Vicente-Zurdo D, Morante-Zarcero S, Sierra I. Green and emerging microextraction strategies for bioanalytical determination of hormones: trends, challenges, and applications. Molecules. 2025;30(22):4471. 24. Latif R, Nawaz T. Medicinal plants and human health: a comprehensive review of bioactive compounds, therapeutic effects, and applications. Phytochem Rev. 2025. 25. Dragomanova S, Tancheva L, Abarova S, Grigorova VB, Gavazova V, Stanciu D, et al. Protective potential of Satureja montana-derived polyphenols in stress-related central nervous system disorders, including dementia. Curr Issues Mol Biol. 2025;47(7):556. 26. Ghosh S, Basu S, Kayal T, Ashok G, Ramaiah S, Anbarasu A. Computational advancements to facilitate therapeutic application of phytochemicals: where do we stand? Discover Appl Sci. 2025;7(5):491. 27. Bácskay I, Arany P, Fehér P, Józsa L, Vasvári G, Nemes D, et al. Bioavailability enhancement and formulation technologies of oral mucosal dosage forms: a review. Pharmaceutics. 2025;17(2):148. 28. Nagarajan P, Kannan S, Raj A, Louis LRP, Bazeer AB, Kaliaperumal R, et al. Future prospects in medicinal plant-derived drug development: unveiling opportunities and challenges. In: Sawicka B, Messaoudi M, Rebiai A, editors. Biotechnology and phytochemical prospects in drug discovery. Singapore: Springer Nature Singapore; 2025. p. 241-266.
International Journal of Brain Sciences
| Volume | 03 |
| Issue | 01 |
| Received | 28/01/2026 |
| Accepted | 30/01/2026 |
| Published | 11/02/2026 |
| Publication Time | 14 Days |
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