Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride

Year : 2024 | Volume : 02 | Issue : 02 | Page : 50 62
    By

    Sd. Riaz Hussain Chistia,

  • N. Jyothi Reddy,

  • H. Padma Latha,

  • CH. Sri Divya,

  • S. Deepa,

  1. Associate Professor, Department of pharmaceutics, gyana college of pharmacy,, Hyderabad, India
  2. Associate Professor, Department of pharmaceutics, gyana college of pharmacy,, Hyderabad, India
  3. Professor, Department of pharmaceutics, gyana college of pharmacy,, Hyderabad, India
  4. Associate Professor, Department of pharmaceutics, gyana college of pharmacy,, Hyderabad, India
  5. Assistant Professor, Department of pharmaceutics, gyana college of pharmacy,, Hyderabad, India

Abstract

The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The mouth-dissolving time varied from 7:06 to 30:28 minutes, with formulation F10 taking the longest to dissolve. The acceptable moisture content for lozenges should range from 0.5% to 1.5%, and the formulated lozenges meet this criterion. The drug content across all formulations (F1–F10) remained within the acceptable range of 90%–110%. In the in-vitro drug release study, metoclopramide hydrochloride lozenges containing methyl cellulose at concentrations of 0.75%, 0.5%, and 0.25% exhibited the highest drug release within 30 minutes, with formulation F10 achieving 100.6% release. The in-vitro release kinetic study of the optimized formulation (F10) followed a first-order release pattern, with drug release governed by diffusion, dissolution, and a non-Fickian diffusion mechanism. Based on this study, isomalt was successfully utilized as a tooth-friendly sugar substitute in medicated lozenges. Due to its low-caloric value and resistance to plaque formation, it can be safely recommended for diabetic and pediatric patients.

Keywords: Formulation Development, Evaluation, Metoclopramide Hydrochloride, Hard Candy Lozenges

[This article belongs to International Journal of Biomedical Innovations and Engineering ]

How to cite this article:
Sd. Riaz Hussain Chistia, N. Jyothi Reddy, H. Padma Latha, CH. Sri Divya, S. Deepa. Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride. International Journal of Biomedical Innovations and Engineering. 2024; 02(02):50-62.
How to cite this URL:
Sd. Riaz Hussain Chistia, N. Jyothi Reddy, H. Padma Latha, CH. Sri Divya, S. Deepa. Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride. International Journal of Biomedical Innovations and Engineering. 2024; 02(02):50-62. Available from: https://journals.stmjournals.com/ijbie/article=2024/view=157026


References

  1. Meghwal M, Goswami TK. Chemical composition, nutritional, medicinal and functional properties of black pepper: a review. Open Acc Sci Rep. 2012;1:1–5.
  2. Paul M, ESCMID guideline for the management of acute sore throat. 2012;18: 1–18.
  3. Maheshwari R, Jain V, Ansari R, et al. A review on lozenges. BBB. 2013;1(1):35–43.
  4. Munot M, Sharma N, Gujar NK. Orodental delivery systems. Int J Pharm Pharmaceut Sci. 2013;5(3):1–10.
  5. Maheshwari R, Jain V, Ansari R, Mahajan SC, Joshi G. A review on lozenges. BBB. 2013;1–9.
  6. Shinde SG, Kadam V, Kapse GR, Jadhav SB, Zameeruddin, Bharkad VB. A review on lozenges. IAJPR. 2014;4(2):567–570.
  7. Pothu R, Yamsani MR. Lozenges formulation and evaluation: a review. IJAPR. 2014;1:290–294.
  8. Shinde SG, Kadam V, Kapse GR, et al. A review on lozenges. Indo American J Pharmaceut Res. 2014;4(1):566–571.
  9. Pundir S, Verma A, Murari L. A review on lozenges. J der Pharma. Forschung. 2014;2(1):1–10.
  10. Shah DP, Gandhi TP. Lozenges as a novel drug delivery system: A review. International Journal of Pharmaceutical Sciences and Research. 2016;7(4):1455–1464.
Regular Issue Subscription Original Research
Volume 02
Issue 02
Received 26/03/2024
Accepted 09/04/2024
Published 20/07/2024
Publication Time 116 Days
379

Login


My IP

PlumX Metrics