Exploring Phytochemicals From Ricinus Communis For Potential Therapeutic Applications In Rheumatoid Arthristis: An In Silico Approach

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Year : 2025 | Volume :03 | Issue : 01 | Page : –
    By

    Gurusowmyasri Kota,

  1. Student, Department of Biotechnology, Garden City University, University in Bengaluru, Karnataka, India

Abstract

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Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions like RA.Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, identifying 95 compounds. Their drug-like properties were evaluated using the SwissADME tool, resulting in the selection of seven compounds: Ricinine, Apigenin, Glycolic acid, Shikimic acid, Nicotinamide, threo-9, 10-Dihydroxystearic acid, and uric acid. Toxicity assessments were conducted using the protox tool. Molecular docking was performed with pyrx to evaluate interactions was achieved using BIOVIA.Results: This study revealed that Ricinus communis Phytochemicals demonstrated strong binding affinities with autoimmune pathway-related proteins 1A8M and 1TNF, indicating significant anti-inflammatory and immunomodulatory potential. These finding suggest their promise as plant-based therapeutic agents for rheumatoid arthritis.Conclusion: This research underscores the promising anti-inflammatory and immunomodulatory properties of phytochemicals derived from Ricinus communis.  The identified compounds exhibit favorable drug-like and safety profiles, with significant binding to autoimmune pathway-related proteins. These findings provide a foundation for experimental studies and the development of plant-based therapies for autoimmune disorders such as RA.

Keywords: Rheumatoid arthritis, Ricinus communis, phytochemicals, autoimmune disorders, molecular docking, anti-inflammatory, immunomodulatory.

[This article belongs to International Journal of Bioinformatics and Computational Biology (ijbcb)]

How to cite this article:
Gurusowmyasri Kota. Exploring Phytochemicals From Ricinus Communis For Potential Therapeutic Applications In Rheumatoid Arthristis: An In Silico Approach. International Journal of Bioinformatics and Computational Biology. 2025; 03(01):-.
How to cite this URL:
Gurusowmyasri Kota. Exploring Phytochemicals From Ricinus Communis For Potential Therapeutic Applications In Rheumatoid Arthristis: An In Silico Approach. International Journal of Bioinformatics and Computational Biology. 2025; 03(01):-. Available from: https://journals.stmjournals.com/ijbcb/article=2025/view=0

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Regular Issue Subscription Original Research
Volume 03
Issue 01
Received 27/12/2024
Accepted 11/01/2025
Published 06/02/2025
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