Invivo Modulatory Effect of Clerodendrum Splendens (Glory Blossom) in Aluminum Induced Alzheimer Diseases and Lonchocarpus Sericeus in Rotenone-Induced Parkinson’s Disease on Na+/K+ Atpase (Sodium Pump) in the Cerebral Tissues of Male Albino Wister Rats

Year : 2023 | Volume : 01 | Issue : 02 | Page : 31-36
By

    Umoh Esther Udo

  1. Ojo Oluwabukola

  1. Researcher, Department of Biochemistry, School of Sciences Federal University of Technology Akure, Ondo State, Nigeria
  2. Researcher, Department of Biochemistry, School of Sciences Federal University of Technology Akure, Ondo State, Nigeria

Abstract

Elegant research has shown that plants are useful for both curative and preventive purpose on the humans populous. Prevalent among diseases associated with humans are neurological diseases which affect a large sector of the population especially the elderly. The most common neurological diseases are Parkinson and Alzheimer disease which affect a large sector of the brain and also cause an imbalance in brain electrolyte. Among such electrolytic mechanisms of the brain are those which regulate the inflow an out flow of sodium and potassium levels in the cerebral tissue and the system responsible for such is the sodium pump. This is a p type ATPase which controls the influx and out flux of sodium and potassium ions in the brain and whose damage can trigger a lot of neurological problems. Due to the important of this “pump”, this research was aimed at examining the modulatory effect of two plants species (Clerodendrum Splendens and Lonchocarpus sericeus) on sodium potassium ATPase in the cerebral tissue of mammals. Methodologies employed in this research are the Na+/K+ ATPase by Svoboda and Mosinger, 1981. All results were estimated at P<0.05. It is interesting to know that result obtained from this research shows that there was no significant different in the sodium potassium ATPase level in group three and four of both groups. However, as compared to the positive control, the sodium potassium ATPase level was higher and to the negative and standard, it almost obtained 100% efficiency. This implies that Clerodendrum Splendens and Lonchocarpus sericeus have great impact on restoring the sodium potassium ATPase activity in the cerebral tissue of Alzheimer and Parkinson disease patients and may also serves as a medicament in treating other neurological disorders.

Keywords: Neurological disease, cerebral tissue, Alzheimer and Parkinson

[This article belongs to International Journal of Biochemistry and Biomolecule Research(ijbbr)]

How to cite this article: Umoh Esther Udo, Ojo Oluwabukola Invivo Modulatory Effect of Clerodendrum Splendens (Glory Blossom) in Aluminum Induced Alzheimer Diseases and Lonchocarpus Sericeus in Rotenone-Induced Parkinson’s Disease on Na+/K+ Atpase (Sodium Pump) in the Cerebral Tissues of Male Albino Wister Rats ijbbr 2023; 01:31-36
How to cite this URL: Umoh Esther Udo, Ojo Oluwabukola Invivo Modulatory Effect of Clerodendrum Splendens (Glory Blossom) in Aluminum Induced Alzheimer Diseases and Lonchocarpus Sericeus in Rotenone-Induced Parkinson’s Disease on Na+/K+ Atpase (Sodium Pump) in the Cerebral Tissues of Male Albino Wister Rats ijbbr 2023 {cited 2023 Nov 12};01:31-36. Available from: https://journals.stmjournals.com/ijbbr/article=2023/view=130077

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Regular Issue Subscription Original Research
Volume 01
Issue 02
Received September 4, 2023
Accepted September 11, 2023
Published November 12, 2023