Butrin Tackles Retinoblastoma – A Clinical Hypothesis †

Year : 2024 | Volume : 02 | Issue : 01 | Page : 26 30
    By

    Rakshana Manikandan,

  • M. Mala,

  • G. Manikandan,

  • Prakash Vaithyanathan,

  1. Trustee, Tagore Educational Trust, Chennai, Tamil Nadu, India
  2. Chairperson and Managing Trustee, Tagore Educational Trust, Chennai, Tamil Nadu, India
  3. Secretary, Tagore Educational Trust, Chennai, Tamil Nadu, India
  4. Science Teacher and Innovator, L.B road, Adyar, Chennai, Tamil Nadu, India

Abstract

Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-taxing sicknesses like cancer, Alzheimer’s/Parkinson’s and acute kidney injury. To suppress the functions of legumain, it is hypothesized that a water soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside) may have the therapeutic potential owing to its special ability to bind to the key catalytic sites of legumain, discovered through bioinformatic studies.  Insights, into the docking structure of butrin were provided with emphasis on the relative binding abilities of various hydroxyl groups of butrin with the amino acid residues of  the legumain protein.

Keywords: Acute kidney injury, Alzheimer’s disease, biomarker, butrin, cancer tumor, legumain, molecular level interaction

[This article belongs to International Journal of Advance in Molecular Engineering ]

How to cite this article:
Rakshana Manikandan, M. Mala, G. Manikandan, Prakash Vaithyanathan. Butrin Tackles Retinoblastoma – A Clinical Hypothesis †. International Journal of Advance in Molecular Engineering. 2024; 02(01):26-30.
How to cite this URL:
Rakshana Manikandan, M. Mala, G. Manikandan, Prakash Vaithyanathan. Butrin Tackles Retinoblastoma – A Clinical Hypothesis †. International Journal of Advance in Molecular Engineering. 2024; 02(01):26-30. Available from: https://journals.stmjournals.com/ijame/article=2024/view=172066


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Regular Issue Subscription Hypothesis
Volume 02
Issue 01
Received 10/09/2024
Accepted 14/09/2024
Published 15/09/2024
328


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