Agricultural Waste-Derived Nanocellulose Composites in Pharmaceutical Packaging: Barrier Performance, Regulatory Considerations and Translational Gaps

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Year : 2026 | Volume : 14 | 05 | Page :
By

Bhawna Pant,

Manish Maan,

  1. Assistant Professor, DBS School of Pharmacy and Research, DBS Global University, Dehradun, Uttarakhand, India
  2. Assistant Professor, Doon School of Modern Agriculture and Forestry, DBS Global University, Dehradun, Uttarakhand, India

Abstract

Pharmaceutical primary packaging is dominated by poly (vinyl chloride) (PVC), poly (vinylidene chloride) laminates and cold-form aluminium, chosen for barrier performance rather than end-of-life behaviour. Nanocellulose from agricultural residues is widely proposed as a renewable alternative, but almost the entire evidence base has been generated against food-packaging requirements. This review re-examines that literature through a pharmaceutical lens. A search of three bibliographic databases covering 2010–2026, supplemented by Google Scholar and citation searching, screened and selected against the PRISMA 2020 flow structure, yielded 68 included studies on isolation routes for rice husk, sugarcane bagasse, rice and sugarcane straw, banana pseudostem, coir and pine needle feedstocks, compared on crystallinity index, particle geometry and residual impurity burden. Composite strategies for mitigating the intrinsic moisture sensitivity of cellulose nanomaterials are assessed, including matrix selection, silanisation, esterification, wax and clay incorporation and multilayer architecture, and are interpreted against Nielsen and Cussler tortuosity models. Reported barrier data are benchmarked against water vapour transmission rates for conventional blister formats, which span approximately two and a half orders of magnitude from PVC to cold-form foil. Package-level and film-level measurement bases are shown to be non-interconvertible and are presented separately. Converting behaviour, the applicable USP, ICH Q1A(R2) and draft ICH Q3E requirements, and toxicological status are then reviewed. Eight translational gaps are identified, the most consequential being the absence of any published stability study with a real active pharmaceutical ingredient and the absence of any thermoforming data. The gaps are prioritised into a staged research roadmap with explicit decision gates, and a minimum reporting framework is proposed. On the present evidence, agricultural-waste nanocellulose composites are suitable candidates for secondary packaging, unit-dose sachets for non-hygroscopic solids, intermediate plies of multilayer laminates and packaging for products that degrade principally by oxidation rather than hydrolysis, but not for high-barrier primary packaging.

Keywords: Nanocellulose, Agricultural waste, Pharmaceutical packaging, Water vapour transmission rate, Cellulose nanocrystals, Extractables and leachables, Barrier composites, Tortuosity

How to cite this article: Bhawna Pant, Manish Maan. Agricultural Waste-Derived Nanocellulose Composites in Pharmaceutical Packaging: Barrier Performance, Regulatory Considerations and Translational Gaps. Journal of Polymer & Composites. 2026; 14(05):-.
How to cite this URL: Bhawna Pant, Manish Maan. Agricultural Waste-Derived Nanocellulose Composites in Pharmaceutical Packaging: Barrier Performance, Regulatory Considerations and Translational Gaps. Journal of Polymer & Composites. 2026; 14(05):-. Available from: https://journals.stmjournals.com/jopc/article=2026/view=259994

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Ahead of Print Subscription Review Article
Volume 14
05
Received 22/09/2026
Accepted 05/10/2026
Published 12/10/2026
Publication Time 20 Days


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