Synthesis, Characterization, and Biomedical Applications of a Silver Nanoparticle-Coated Chitosan–Fucoidan–Polymer Nanocomposite Loaded with Persea americana Leaf Extract

Open Access

Year : 2026 | Volume : 14 | Issue : 05 | Page : 130 148
By

S. Divya Priya,

K. Rajathi,

M. E. Pavithra,

Mekala Moorthy,

G. Nivetha,

J. Srinaya,

  1. Assistant Professor, Department of Biochemistry, Dr. N. G. P. Arts and Science College, Coimbatore, Tamil Nadu, India
  2. Professor, Department of Biochemistry, Dr. N. G. P. Arts and Science College, Coimbatore, Tamil Nadu, India
  3. Associate Professor, Department of Microbiology, KMCH Institute of Health Science, Coimbatore, Tamil Nadu, India
  4. Assistant Professor, Department of OBG Nursing, KMCH College of Nursing, Coimbatore, Tamil Nadu, India
  5. M.Sc. (Biochemistry), Department of Biochemistry, Dr. N. G. P. Arts and Science College, Coimbatore, Tamil Nadu, India
  6. M.Sc. (Biochemistry), Department of Biochemistry, Dr. N. G. P. Arts and Science College, Coimbatore, Tamil Nadu, India

Abstract

Consuming a natural composite of Persea americana (Avocado) leaf extract and a chitosan and fucoidan form a biodegradable biopolymer matrix–polymer nanocomposite with biomedical applications, this study explored a potential therapeutic method. GC–MS and UV spectroscopy were used to describe the aqueous leaf extract, which was verified by phytochemical screening to contain flavonoids, tannins, phenols, terpenoids, and alkaloids. The chitosan–fucoidan biodegradable polymer matrix served as a biocompatible stabilizing and encapsulating carrier for silver nanoparticles (AgNPs), enhancing nanoparticle stability, controlled phytochemical release, and overall biomedical performance. To improve bioavailability and activity, it was added to a biopolymer matrix that had been coated with silver nanocomposite. Strong dose-dependent radical scavenging effects were demonstrated by antioxidant capacity as assessed by phosphomolybdic acid, hydrogen peroxide, DPPH, and FRAP assays. Tests of antifungal activity were conducted against Candida tropicalis and Candida albicans. Pancreatic lipase and α-amylase inhibition assays were used to measure anti-obesity and anti-diabetic potential. Significant protein stabilization and denaturation inhibition were found when anti-inflammatory activity was assessed using heat-induced hemolysis and albumin denaturation assays. In the absence of additional clinical validation, this biopolymer–nanoparticle delivery system shows promise as a treatment candidate for PCOS by providing a biocompatible, environmentally benign method of controlling oxidative stress and inflammation.

Keywords: Green synthesis, chitosan–fucoidan, biomedical polymer nanocomposite, antioxidant, antifungal, anti-inflammatory.

[This article belongs to Journal of Polymer & Composites ]

How to cite this article: S. Divya Priya, K. Rajathi, M. E. Pavithra, Mekala Moorthy, G. Nivetha, J. Srinaya. Synthesis, Characterization, and Biomedical Applications of a Silver Nanoparticle-Coated Chitosan–Fucoidan–Polymer Nanocomposite Loaded with Persea americana Leaf Extract. Journal of Polymer & Composites. 2026; 14(05):130-148.
How to cite this URL: S. Divya Priya, K. Rajathi, M. E. Pavithra, Mekala Moorthy, G. Nivetha, J. Srinaya. Synthesis, Characterization, and Biomedical Applications of a Silver Nanoparticle-Coated Chitosan–Fucoidan–Polymer Nanocomposite Loaded with Persea americana Leaf Extract. Journal of Polymer & Composites. 2026; 14(05):130-148. Available from: https://journals.stmjournals.com/jopc/article=2026/view=252254

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Regular Issue Open Access Original Research
Volume 14
Issue 05
Received 21/07/2026
Accepted 29/07/2026
Published 13/08/2026
Publication Time 23 Days

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