A Systematic Review of the Herbal Medicinal Plants With Anti-Obesity Potential

Year : 2026 | Volume : 15 | 02 | Page :
    By

    Deeksha M,

  1. Student, Department of Pharamacognosy Krupanidhi College of Pharmacy, ,

Abstract

Obesity is a chronic, multifactorial metabolic condition characterized by abnormal fat accumulation. It is mainly driven by the intricate influence of genetic, environmental, hormonal, metabolic and lifestyle determinants. The burden of obesity has risen considerably over the past few years, making it one of the major health concerns in both developed and developing countries alike. The rapid increase globally in obesity prevalence is linked with numerous health complications such as Type 2 diabetes mellitus, hypertension, and respiratory complications, creating a necessary and urgent need for the development of safer and more effective therapeutic strategies.  Although several synthetic anti-obesity drugs are available, due to their adverse effects and insufficient patient adherence, their long-term use is limited. Owing to the adverse effects of synthetic anti-obesity drugs, herbal medicinal plants offer safer therapeutic alternatives.  The present review comprehensively examines the currently available scientific evidence on herbal medicinal plants that possess anti-obesity properties, including the part of the plant used and the extraction methods. The synthesised evidence demonstrates that numerous herbal medicinal plants possess anti-obesity activity through diverse mechanisms, including appetite regulation, inhibition of lipid absorption, stimulation of lipolysis and thermogenesis, modulation of adipogenesis, increased energy expenditure, and enhanced glucose and lipid metabolism. This review was conducted by searching bibliographic databases, including PubMed, Scopus, Google Scholar, and Medex, for studies. Although various promising anti-obesity effects are reported for various herbal medicinal plants, their successful clinical utilization continues to be challenged by inadequate robust clinical data, lack of formulation standardization, variations in phytochemical composition, and regulatory concerns. Collectively, the reviewed findings support the potential of herbal medicinal plants to show complementary approaches in the treatment and management of obesity. However, further well-designed clinical trials and standardization of herbal formulations and detailed studies are required to incorporate evidence-based clinical practices.

Keywords: Obesity, Anti-obesity activity, BMI(Body mass index), Complications, Pathophysiology, Mechanism of action, Herbal medicinal plants, Discussion.

How to cite this article:
Deeksha M. A Systematic Review of the Herbal Medicinal Plants With Anti-Obesity Potential. Research & Reviews : Journal of Herbal Science. 2026; 15(02):-.
How to cite this URL:
Deeksha M. A Systematic Review of the Herbal Medicinal Plants With Anti-Obesity Potential. Research & Reviews : Journal of Herbal Science. 2026; 15(02):-. Available from: https://journals.stmjournals.com/rrjohs/article=2026/view=248884


References

  1. A. Elghazaly, N. A., H. Radwan, E., Zaatout, H. H., Elghazaly, M. M., & Allam, N. E. din. (2019). Beneficial Effects of Fennel (Foeniculum Vulgare) in Treating Obesity in Rats. Journal Of Obesity Management, 1(2), 16–33. https://doi.org/10.14302/issn.2574-450x.jom-18-2484
  2. Arora, E., Khajuria, V., Tandon, V., Sharma, A., Mahajan, A., Gillani, Z., & Choudhary, N. (2015). To evaluate efficacy and safety of Caralluma fimbriata in overweight and obese patients: A randomized, single-blinded, placebo control trial. Perspectives in Clinical Research, 6(1), 39. https://doi.org/10.4103/2229-3485.148812
  3. Bhutani, K. K., Birari, R., & Kapat, K. (2007). Potential anti-obesity and lipid lowering natural products: A review. Natural Product Communications, 2(3), 331–348. https://doi.org/10.1177/1934578×0700200316

Bonde, A. R., & Pinjari, R. M. (2023). Hoodia Gordonii a herbal plant: A Review. International Journal of Rural Development, Environment and Health Research, 7(5), 98–106. https://doi.org/10.22161/ijreh.7.5.8

  1. Charkravarty, A., & Ramasamy, G. (2023). Profiling of volatiles in tissues of Salacia reticulata Wight. with anti-diabetic potential using GC-MS and molecular docking. ArXiv Preprint, 2307.04109.
  2. Chung, M. Y., Hwang, J. T., & Park, S. H. (2023). Antiobesity effects of onion (Allium cepa) in subjects with obesity: Systematic review and meta-analysis. Food Science and Nutrition, 11(8), 4409–4418. https://doi.org/10.1002/fsn3.3426
  3. Eid, H. M., Ouchfoun, M., Brault, A., Vallerand, D., Musallam, L., Arnason, J. T., & Haddad, P. S. (2014). Lingonberry (Vaccinium vitis-idaea L.) exhibits antidiabetic activities in a mouse model of diet-induced obesity. Evidence-Based Complementary and Alternative Medicine, 2014. https://doi.org/10.1155/2014/645812
  4. Haidari, F., Samadi, M., Mohammadshahi, M., Jalali, M. T., & Engali, K. A. (2017). Energy restriction combined with green coffee bean extract affects serum adipocytokines and the body composition in obese women. Asia Pacific Journal of Clinical Nutrition, 26(6), 1048–1054. https://doi.org/10.6133/apjcn.022017.03
  5. Han, L. K., Zheng, Y. N., Yoshikawa, M., Okuda, H., & Kimura, Y. (2005). Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complementary and Alternative Medicine, 5, 1–10. https://doi.org/10.1186/1472-6882-5-9
  6. Hasani-Ranjbar, S., Jouyandeh, Z., & Abdollahi, M. (2013). A systematic review of anti-obesity medicinal plants – an update. Journal of Diabetes and Metabolic Disorders, 12(1). https://doi.org/10.1186/2251-6581-12-28
  7. He, Y., Tao, Y., Qiu, L., Xu, W., Huang, X., Wei, H., & Tao, X. (2022). Lotus (Nelumbo nucifera Gaertn.) Leaf-Fermentation Supernatant Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Induced Obese Rats. Nutrients, 14(20), 1–17. https://doi.org/10.3390/nu14204348
  8. Herranz-López, M., Olivares-Vicente, M., Encinar, J. A., Barrajón-Catalán, E., Segura-Carretero, A., Joven, J., & Micol, V. (2017). Multi-targeted molecular effects of Hibiscus sabdariffa polyphenols: An opportunity for a global approach to obesity. Nutrients, 9(8). https://doi.org/10.3390/nu9080907
  9. Jyotirmayee, B., & Mahalik, G. (2022). A review on selected pharmacological activities of Curcuma longa L. International Journal of Food Properties, 25(1), 1377–1398. https://doi.org/10.1080/10942912.2022.2082464
  10. Kang, Y.-R., Lee, H.-Y., Kim, J.-H., Moon, D.-I., Seo, M.-Y., Park, S.-H., Choi, K.-H., Kim, C.-R., Kim, S.-H., Oh, J.-H., Cho, S.-W., Kim, S.-Y., Kim, M.-G., Chae, S.-W., Kim, O., & Oh, H.-G. (2012). Anti-obesity and anti-diabetic effects of Yerba Mate ( Ilex paraguariensis ) in C57BL/6J mice fed a high-fat diet . Laboratory Animal Research, 28(1), 23. https://doi.org/10.5625/lar.2012.28.1.23
  11. Karimi, A., Majlesi, M., & Rafieian-Kopaei, M. (2015). Herbal versus synthetic drugs; beliefs and facts. Journal of Nephropharmacology, 4(1), 27–30. http://www.ncbi.nlm.nih.gov/pubmed/28197471%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5297475
  12. Kazemipoor, M., Cordell, G. A., Sarker, M. M. R., Radzi, C. W. J. B. W. M., Hajifaraji, M., & En Kiat, P. (2015). Alternative Treatments for Weight Loss: Safety/Risks and Effectiveness of Anti-Obesity Medicinal Plants. International Journal of Food Properties, 18(9), 1942–1963. https://doi.org/10.1080/10942912.2014.933350
  13. Kilany, O. E., Abdelrazek, H. M. A., Aldayel, T. S., Abdo, S., & Mahmoud, M. M. A. (2020). Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats. Saudi Journal of Biological Sciences, 27(10), 2733–2746. https://doi.org/10.1016/j.sjbs.2020.06.026
  14. Kim, S. Y., Oh, M. R., Kim, M. G., Chae, H. J., & Chae, S. W. (2015). Anti-obesity effects of Yerba Mate (Ilex Paraguariensis): A randomized, double-blind, placebo-controlled clinical trial. BMC Complementary and Alternative Medicine, 15(1), 1–8. https://doi.org/10.1186/s12906-015-0859-1
  15. Kong, Y., Yang, H., Nie, R., & Zhang, X. (2024). Progress of the anti-obesity of Berberine. Kunming Medical University, 1–6.
  16. Kumar, M., Kaushik, D., Kaur, J., Proestos, C., Oz, F., Oz, E., Gupta, P., Kundu, P., Kaur, A., Anisha, A., & Ritika, R. (2022). A Critical Review on Obesity: Herbal Approach, Bioactive Compounds, and Their Mechanism. Applied Sciences (Switzerland), 12(16), 1–19. https://doi.org/10.3390/app12168342
  17. Labban, L., Mustafa, U. E.-S., & Ibrahim, Y. M. (2014). The Effects of Rosemary (Rosmarinus officinalis) Leaves Powder on Glucose Level, Lipid Profile and Lipid Perodoxation. International Journal of Clinical Medicine, 05(06), 297–304. https://doi.org/10.4236/ijcm.2014.56044
  18. Lim, S. H., Lee, H. S., Lee, C. H., & Choi, C. I. (2021). Pharmacological Activity of Garcinia indica (Kokum): An Updated Review. Pharmaceuticals, 14(12), 1–13. https://doi.org/10.3390/ph14121338
  19. Lim, T. K. (2013). Edible Medicinal and Non-Medicinal Plants: Volume 5, Fruits. In Edible Medicinal and Non-Medicinal Plants: Volume 5, Fruits (Vol. 5). https://doi.org/10.1007/978-94-007-5653-3
  20. Lipids, B., & Control, W. (2018). Green Coffee Bean Extract Improves Body Composition and Lipid Metabolism in Obese Individuals. (2017).
  21. Majeed, M., Majeed, S., Nagabhushanam, K., Lawrence, L., & Mundkur, L. (2020). Garcinia indica extract standardized for 20% Garcinol reduces adipogenesis and high fat diet-induced obesity in mice by alleviating endoplasmic reticulum stress. Journal of Functional Foods, 67(February), 103863. https://doi.org/10.1016/j.jff.2020.103863
  22. Mane, K. (2012). Journal of Advanced Scientific Research. … of Advanced Scientific …, 1(2), 19–23. http://www.sciensage.info/journal/1359303580JASR_3006121.pdf
  23. Medagama, A. B. (2015). The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials. Nutrition Journal, 14(1), 1–12. https://doi.org/10.1186/s12937-015-0098-9
  24. Meireles, D., Gomes, J., Lopes, L., Hinzmann, M., & Machado, J. (2020). A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: integrative approach on conventional and traditional Asian medicine. Advances in Traditional Medicine, 20(4), 495–515. https://doi.org/10.1007/s13596-020-00468-0
  25. Noreen, S., Tufail, T., Badar Ul Ain, H., & Awuchi, C. G. (2023). Pharmacological, nutraceutical, functional and therapeutic properties of fennel (foeniculum vulgare). International Journal of Food Properties, 26(1), 915–927. https://doi.org/10.1080/10942912.2023.2192436
  26. Odendaal, A. Y., Deshmukh, N. S., Marx, T. K., Schauss, A. G., Endres, J. R., & Clewell, A. E. (2013). Safety assessment of a hydroethanolic extract of caralluma fimbriata. International Journal of Toxicology, 32(5), 385–394. https://doi.org/10.1177/1091581813492827
  27. Parveen, A., Parveen, B., Parveen, R., & Ahmad, S. (2015). Challenges and guidelines for clinical trial of herbal drugs. Journal of Pharmacy and Bioallied Sciences, 7(4), 329–333. https://doi.org/10.4103/0975-7406.168035
  28. Roza, O., Lovász, N., Zupkó, I., Hohmann, J., & Csupor, D. (2013). Sympathomimetic activity of a hoodia gordonii product: A possible mechanism of cardiovascular side effects. BioMed Research International, 2013, 15–17. https://doi.org/10.1155/2013/171059
  29. Saad, B. (2023). A Review of the Anti-Obesity Effects of Wild Edible Plants in the Mediterranean Diet and Their Active Compounds: From Traditional Uses to Action Mechanisms and Therapeutic Targets. International Journal of Molecular Sciences, 24(16). https://doi.org/10.3390/ijms241612641
  30. Shaik Mohamed Sayed, U. F., Moshawih, S., Goh, H. P., Kifli, N., Gupta, G., Singh, S. K., Chellappan, D. K., Dua, K., Hermansyah, A., Ser, H. L., Ming, L. C., & Goh, B. H. (2023). Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management. Frontiers in Pharmacology, 14(June), 1–30. https://doi.org/10.3389/fphar.2023.1182937
  31. Sung, Y. Y., Yoon, T., Yang, W. K., Moon, B. C., & Kim, H. K. (2013). Anti-obesity effects of actinidia polygama extract in mice with high-fat diet induced obesity. Molecular Medicine Reports, 7(2), 396–400. https://doi.org/10.3892/mmr.2012.1239
  32. Tainaka, T., Shimada, Y., Kuroyanagi, J., Zang, L., Oka, T., Nishimura, Y., Nishimura, N., & Tanaka, T. (2011). Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutrition and Metabolism, 8, 1–11. https://doi.org/10.1186/1743-7075-8-88
  33. Tavakkoli, A., Mahdian, V., Razavi, B. M., & Hosseinzadeh, H. (2017). Review on clinical trials of black seed (Nigella sativa ) and its active constituent, thymoquinone. Journal of Pharmacopuncture, 20(3), 179–193. https://doi.org/10.3831/kpi.2017.20.021
  34. Tsuruta, Y., Nagao, K., Kai, S., Tsuge, K., Yoshimura, T., Koganemaru, K., & Yanagita, T. (2011). Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. Lipids in Health and Disease, 10, 1–8. https://doi.org/10.1186/1476-511X-10-202
  35. Velusami, C. C., Agarwal, A., & Mookambeswaran, V. (2013). Effect of nelumbo nucifera petal extracts on lipase, adipogenesis, adipolysis, and central receptors of obesity. Evidence-Based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/2013/145925
  36. Wang, S., Zeng, T., Zhao, S., Zhu, Y., Feng, C., Zhan, J., Li, S., Ho, C. T., & Gosslau, A. (2022). Multifunctional health-promoting effects of oolong tea and its products. Food Science and Human Wellness, 11(3), 512–523. https://doi.org/10.1016/j.fshw.2021.12.009
  37. Wasim, R., Mahmood, T., Shamim, A., Ahsan, F., & Singh, A. (2024). Metaphorical investigation of aqueous distillate of Cichorium intybus, Foeniculum vulgare and Solanum nigrum along with atorvastatin and orlistat in experimental rodent models of dyslipidaemia and obesity. Intelligent Pharmacy, 2(1), 1–11. https://doi.org/10.1016/j.ipha.2023.08.011
  38. Wu, Y., Tan, F., Zhang, T., Xie, B., Ran, L., & Zhao, X. (2020). The anti-obesity effect of lotus leaves on high-fat-diet-induced obesity by modulating lipid metabolism in C57BL/6J mice. Applied Biological Chemistry, 63(1). https://doi.org/10.1186/s13765-020-00541-x
  39. Yadav, M., Jyoti, J., Mohanta, R., & Ks, Y. (2019). Ethnopharmacological Approach of Anti-obesity Medicinal Plants: A Review. ~ 1793 ~ Journal of Pharmacognosy and Phytochemistry, 8(1), 1793–1798.
  40. Yadav, U. C. S., & Baquer, N. Z. (2014). Pharmacological effects of Trigonella foenum-graecum L. in health and disease. Pharmaceutical Biology, 52(2), 243–254. https://doi.org/10.3109/13880209.2013.826247
  41. Yuan, E., Duan, X., Xiang, L., Ren, J., Lai, X., Li, Q., Sun, L., & Sun, S. (2018). Aged oolong tea reduces high-fat diet-induced fat accumulation and dyslipidemia by regulating the AMPK/ACC signaling pathway. Nutrients, 10(2). https://doi.org/10.3390/nu10020187
Ahead of Print Subscription Review Article
Volume 15
02
Received 15/06/2026
Accepted 30/06/2026
Published 30/06/2026
Publication Time 15 Days
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