Comparative Assessment of Methylparaben concentration in Cosmetic product, analyzed using Enzyme Biosensor and ultra-high-pressure liquid chromatography (UPLC): An approach towards detection of the environmental toxicant with higher accuracy and sensitivity

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Year : 2026 | Volume : 28 | 02 | Page :
    By

    Pooja Upadhyay,

  • Pammi Gauba,

  • Ashwani Mathur,

  1. Research Scholar, department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India
  2. Professor and Head, department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India
  3. Professor, department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India

Abstract

Methylparaben (MP) is one of the most widely used preservatives and is associated with a catalog of recently identified health hazards. Existing studies have also highlighted these compounds as environmental contaminants and toxicants that affect water quality and the associated microbial diversity of the habitat. The conventional methods for parabens detection is performed using chromatographic techniques, which assist in quantitative analysis of the group of compounds. However, the biggest challenge is the fact that such techniques are often time- consuming and costly. Furthermore, the pre-processing of samples is often required before chromatographic analysis. The growing scientific interest towards development of rapid detection techniques for the group of compounds, had brought a paradigm shift towards accepting the emerging techniques including nanotechnology and electrochemistry, for rapid detection of parabens. In the quest to explore and fabricate a point-of-detection device and develop a rapid detection method for low level quantification of MP, the current study highlights the use of a novel enzyme-based biosensor, designed by our group, to detect methylparaben concentration in one of the personal care products (PCP), commercially available in India. The comparative assessment of the Methylparaben concentration in the cosmetic sample, determined using the fabricated esterase-enzyme-based electrochemical biosensor, was observed to be more accurate than Ultra-High-Performance Liquid Chromatography (UPLC). The results indicate the applicability, accuracy, and sensitivity of the designed biosensor for quantifying methylparaben in cosmetic samples.

Keywords: Parabens, Methylparaben, electrochemical, biosensor, voltammetry, chromatography

How to cite this article:
Pooja Upadhyay, Pammi Gauba, Ashwani Mathur. Comparative Assessment of Methylparaben concentration in Cosmetic product, analyzed using Enzyme Biosensor and ultra-high-pressure liquid chromatography (UPLC): An approach towards detection of the environmental toxicant with higher accuracy and sensitivity. Nano Trends – A Journal of Nano Technology & Its Applications. 2026; 28(02):-.
How to cite this URL:
Pooja Upadhyay, Pammi Gauba, Ashwani Mathur. Comparative Assessment of Methylparaben concentration in Cosmetic product, analyzed using Enzyme Biosensor and ultra-high-pressure liquid chromatography (UPLC): An approach towards detection of the environmental toxicant with higher accuracy and sensitivity. Nano Trends – A Journal of Nano Technology & Its Applications. 2026; 28(02):-. Available from: https://journals.stmjournals.com/nts/article=2026/view=243024


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Ahead of Print Subscription Review Article
Volume 28
02
Received 03/04/2026
Accepted 09/04/2026
Published 05/05/2026
Publication Time 32 Days
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