In Silico Screening and Molecular Docking of Cynodon dactylon phytochemicals against COPD-Associated Proteins

Year : 2026 | Volume : 16 | 02 | Page :
    By

    Namita Krishnakumar,

  • Deekshitha M,

  1. Student, Department of Pharmacy, Chanakya University, Haralur, Karnataka, India
  2. Research Associate, Department of Pharmacy, Chanakya University, Haralur, Karnataka, India

Abstract

Chronic Obstructive Pulmonary Disease or COPD is a pulmonary disease that obstructs airways and alveoli accompanied by respiratory issues like emphysema and bronchitis. This disease is caused mainly by inflammatory responses of the body to foreign particles that enter the respiratory path including tobacco smoke, air pollutants and irritants. The hallmark of COPD is excessive inflammation caused by imbalance in protease anti-protease activity. Proteases like elastase breakdown the ECM of alveoli in lung and the antiproteases like alpha- 1-antitrypsin help curb the protease activity protecting the lung tissue. The imbalance here causes excessive elastase activity leading to deterioration of lung tissue. Drugs have been administered for the treatment of COPD such as short- and long-acting β2-agonists (SABA and LABA) but these primarily target specific pathways. To help in effective COPD management, research is being pursued on drugs and lead molecules that can target multiple COPD pathways with less side effects. Cynodon dactylon or durva is used in traditional Ayurvedic and folk medicine for its anti-inflammatory, wound healing and anti-oxidant properties. Owing to the inflammatory response in COPD, bermuda grass(durva) seemed to be a viable subject of study to look into its COPD targets and the properties of its phytocompounds. This in silico study aimed to understand the potential of phytocompounds present in durva for multiple pathway COPD treatment. It includes molecular docking of Durva phytocompounds with the proteins like MMP9, IL-8 and TNF alpha, proteins involved in major COPD pathways to evaluate binding affinity and potential for lead molecules.

Keywords: COPD, emphysema, bronchitis, tobacco smoke, inflammation, Cynodon dactylon, anti-inflammatory, in silico, molecular docking

How to cite this article:
Namita Krishnakumar, Deekshitha M. In Silico Screening and Molecular Docking of Cynodon dactylon phytochemicals against COPD-Associated Proteins. Research and Reviews: A Journal of Pharmacology. 2026; 16(02):-.
How to cite this URL:
Namita Krishnakumar, Deekshitha M. In Silico Screening and Molecular Docking of Cynodon dactylon phytochemicals against COPD-Associated Proteins. Research and Reviews: A Journal of Pharmacology. 2026; 16(02):-. Available from: https://journals.stmjournals.com/rrjop/article=2026/view=242875


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Ahead of Print Subscription Original Research
Volume 16
02
Received 14/04/2026
Accepted 02/05/2026
Published 04/05/2026
Publication Time 20 Days
48

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