This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.
Heena T. Shaikh,
IR. Dr. Kazi Kutubuddin Sayyad Liyakat,
- Assistant Professor, Department of Electronics and Telecommunication Engineering, Brahmdevdada Mane Institute of Technology, Solapur, Maharashtra, India
- Professor and Head, Department of Electronics and Telecommunication Engineering, Brahmdevdada Mane Institute of Technology, Solapur, Maharashtra, India
Abstract
The artificial heart has moved from a visionary concept to a clinically viable organreplacement technology, yet its longterm success hinges on the sophistication of its control architecture. This paper presents a comprehensive investigation of closedloop control strategies that enable an artificial heart to mimic the dynamic, beattobeat adaptability of its biological counterpart. We first construct a highfidelity cardiovascular model that integrates ventricular elastance, systemic and pulmonary vascular compliance, and realtime autonomic feedback. Building on this platform, three families of controllers are examined: (i) a modelpredictive controller (MPC) that anticipates hemodynamic disturbances by solving a constrained optimization problem at each cardiac cycle; (ii) an adaptive fuzzylogic controller (AFLC) that learns patientspecific nonlinear relationships between preload, afterload, and contractility; and (iii) a sensorfusion proportionalintegralderivative (PID) scheme that fuses pressure, flow, and bioimpedance signals to compensate for sensor dropout and noise. Simulation results across a spectrum of physiological challenges—including rapid postural changes, exerciseinduced demand, and sudden vascular occlusion—demonstrate that the MPC consistently maintains arterial pressure within ±5 % of target values while minimizing energy consumption. The AFLC exhibits superior robustness to model mismatch and patient variability, whereas the sensorfusion PID offers the most straightforward implementation with acceptable performance. A hybrid controller that blends MPC’s foresight with AFLC’s adaptability is proposed, achieving the best tradeoff between precision, resilience, and computational load. These findings illuminate a pathway toward nextgeneration artificial hearts that can autonomously regulate circulation with a level of finesse previously reserved for living tissue.
Keywords: Control, Artificial Heart, Sensor, Actuator, Pressure.
Heena T. Shaikh, IR. Dr. Kazi Kutubuddin Sayyad Liyakat. A study on Controlling Artificial Heart. Journal of Control & Instrumentation. 2026; 17(01):-.
Heena T. Shaikh, IR. Dr. Kazi Kutubuddin Sayyad Liyakat. A study on Controlling Artificial Heart. Journal of Control & Instrumentation. 2026; 17(01):-. Available from: https://journals.stmjournals.com/joci/article=2026/view=238901
References
1. Yu YC, Boston JR, Simaan MA, Antaki JF. Minimally invasive estimation of systemic vascular parameters for artificial heart control. Control Engineering Practice. 2002 Mar 1;10(3):277-85.
2. Pierce WS, Brighton JA, Donachy JH, Landis DL, Rosenberg G, Prophet GA, White WJ, Waldhausen JA. The artificial heart: Progress and promise. Archives of Surgery. 1977 Dec 1;112(12):1430-8.
3. Chen Q, Wong SC, Chi KT, Ruan X. Analysis, design, and control of a transcutaneous power regulator for artificial hearts. IEEE Transactions on Biomedical Circuits and Systems. 2009 Jan 20;3(1):23-31.
4. Kosaka R, Yanagi K, Sato T, Ishitoya H, Ichikawa S, Motomura T, Kawahito S, Mikami M, Linneweber J, Nonaka K, Takano T. Operating point control system for a continuous flow artificial heart: in vitro study. ASAIO journal. 2003 May 1;49(3):259-64.
5. Kobayashi M, Horvath DJ, Mielke N, Shiose A, Kuban B, Goodin M, Fukamachi K, Golding LA. Progress on the design and development of the continuous‐flow total artificial heart. Artificial organs. 2012 Aug;36(8):705-13.
6. Saito I, Chinzei T, Abe Y, Ishimaru M, Mochizuki S, Ono T, Isoyama T, Iwasaki K, Kouno A, Baba A, Ozeki T. Progress in the control system of the undulation pump total artificial heart. Artificial organs. 2003 Jan;27(1):27-33.
7. Hajiheydari N, Mahdavi A, Shafiei A. Developing a Holistic Business Process Management Maturity Model (BPM3). Internationa Journal of Engineering and Technical Research. 2014;2(2).
8. Stanley TH, Kolff WJ. Metabolic monitoring and control of the artificial heart. The Journal of Thoracic and Cardiovascular Surgery. 1974 Mar 1;67(3):434-9.
9. Zhang H, Ding Y, Cao L, Wang X, Feng L. Fine-grained question-level deception detection via graph-based learning and cross-modal fusion. IEEE Transactions on Information Forensics and Security. 2022 Jun 27;17:2452-67.
10. Chen J, Jastrzebska-Perfect P, Chai P, Say MG, Tu J, Gao W, Halperin F, Korzenik J, Huang HW, Katabi D, Traverso G. Barriers to translating continuous monitoring technologies for preventative medicine. Nature biomedical engineering. 2025 Nov 14:1- 9.
11. Miller L, Birks E, Guglin M, Lamba H, Frazier OH. Use of ventricular assist devices and heart transplantation for advanced heart failure. Circulation research. 2019 May 24;124(11):1658-78.
12. Yau TM, Pagani FD, Mancini DM, Chang HL, Lala A, Woo YJ, Acker MA, Selzman CH, Soltesz EG, Kern JA, Maltais S. Intramyocardial injection of mesenchymal precursor cells and successful temporary weaning from left ventricular assist device support in patients with advanced heart failure: a randomized clinical trial. Jama. 2019 Mar 26;321(12):1176-86.
13. Syed F, Khan S, Toma M. Modeling dynamics of the cardiovascular system using fluid- structure interaction methods. Biology. 2023 Jul 21;12(7):1026.
14. Vu V, Rossini L, Del Alamo JC, Dembitsky W, Gray RA, May-Newman K. Benchtop models of patient-specific intraventricular flow during heart failure and LVAD support. Journal of Biomechanical Engineering. 2023 Nov 1;145(11):111010.

Journal of Control & Instrumentation
| Volume | 17 |
| 01 | |
| Received | 26/02/2026 |
| Accepted | 27/02/2026 |
| Published | 20/03/2026 |
| Publication Time | 22 Days |
Login
PlumX Metrics