POLYMER NANOCOMPOSITES AS EMERGING PLATFORMS IN PHARMACEUTICAL NANOTECHNOLOGY

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Year : 2026 | Volume : 14 | 01 | Page :
    By

    Lakshman Kumar Dogiparthi,

  • Balakrishna Talamanchi,

  • Mynam Harika,

  • Vannappagari Prabhash,

  • Raichur Ruhinaz,

  • Kora keerthi,

  • A. Jayanth,

  • P. Amitha,

  • Bezawada Siva Nagaraju,

  • Guggulotu Vishnu Tulasi Naik,

  1. Associate Professor, Department of Pharmacognosy, MB School of Pharmaceutical Sciences, Mohan Babu University, Tirupati, Andhra Pradesh, India
  2. Professor and HOD, Department of Pharmaceutics, V. V. Institute of Pharmaceutical sciences, Gudlavalleru, Andhra Pradesh, India
  3. Assistant Professor, Department of Pharmaceutics, V. V. Institute of Pharmaceutical sciences, Gudlavalleru, Andhra Pradesh, India
  4. Student, Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
  5. Student, Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
  6. Student, Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
  7. Student, Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
  8. Student, Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
  9. Student, Department of Pharmaceutics, V. V. Institute of Pharmaceutical sciences, Gudlavalleru, Andhra Pradesh, India
  10. Student, Department of Pharmaceutics, V. V. Institute of Pharmaceutical sciences, Gudlavalleru, Andhra Pradesh, India

Abstract

Nanotechnology allows the handling of materials in the 1-100 nm range, where distinct physicochemical phenomena, including quantum effects and higher surface-to-volume ratio, enable disruptive uses in pharmaceuticals and biomedicine. Significant challenges in solubility, stability and targeted biodistribution of therapeutics can be overcome by incorporating nanostructured polymers and polymer-based composites into drug delivery systems. PLGA nanoparticle and other nanocarriers, such as PLGA micelles, dendrimers, and hydrogels, have revealed promising effects on enhanced bioavailability and reduced systemic toxicity of chemotherapeutics, proteins, and nucleic acids. The non-covalent modification or immobilisation at specific locations on a drug has been achieved through smart polymer platforms which respond to pH, redox state and temperature enabling site-specific drug release and theranostic functionalities. The incorporation of artificial intelligence and machine learning extends to the design, optimisation and predictive modelling of the performance of polymeric nanomedicines. The recent developments in the areas of high-throughput screening, nano-enabled microfluidics and polymer-based nanocomposites and nanoscience and nanotechnology applications have facilitated drug discovery and have extended applications in bioimaging, sensing and environmental remediation with polymer based nanocomposites containing graphene, carbon nanotubes or iron oxide nanoparticles. Although encouraging, challenges such as difficulties in large-scale production, quality control, long term safety and harmonised standards continue to limit the clinical translation of nanomedicines. Ethical aspects of patient safety, data confidentiality and equitable accessibility should be addressed as well. The future brings personalized nanomedicine, self-governing intelligent nanorobots, green bio-degradable polymers, and lives feedback nanoplatforms. This discussion highlights the key role of polymeric nanocomposites in pharmaceutical nanotechnology and emphasizes the need of the interdisciplinary research and ethical governance in advancing safe, effective and accessible to globally nanotherapeutic solutions.

Keywords: Nanotechnology, Polymeric Nanocomposites, Artificial Intelligence, quantum dots, PLGA nanoparticle.

How to cite this article:
Lakshman Kumar Dogiparthi, Balakrishna Talamanchi, Mynam Harika, Vannappagari Prabhash, Raichur Ruhinaz, Kora keerthi, A. Jayanth, P. Amitha, Bezawada Siva Nagaraju, Guggulotu Vishnu Tulasi Naik. POLYMER NANOCOMPOSITES AS EMERGING PLATFORMS IN PHARMACEUTICAL NANOTECHNOLOGY. Journal of Polymer & Composites. 2026; 14(01):-.
How to cite this URL:
Lakshman Kumar Dogiparthi, Balakrishna Talamanchi, Mynam Harika, Vannappagari Prabhash, Raichur Ruhinaz, Kora keerthi, A. Jayanth, P. Amitha, Bezawada Siva Nagaraju, Guggulotu Vishnu Tulasi Naik. POLYMER NANOCOMPOSITES AS EMERGING PLATFORMS IN PHARMACEUTICAL NANOTECHNOLOGY. Journal of Polymer & Composites. 2026; 14(01):-. Available from: https://journals.stmjournals.com/jopc/article=2026/view=236244


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Ahead of Print Subscription Review Article
Volume 14
01
Received 29/08/2025
Accepted 10/09/2025
Published 20/01/2026
Publication Time 144 Days
17

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