Organic Compounds as Anti-inflammatory Agents, Natural and Synthetic

Year : 2026 | Volume : 13 | 01 | Page :
    By

    Khalid M. Darwish,

  • Ehab El-Hawary,

  1. Faculty of Science, Department of Chemistry, University of Benghazi, Benghazi, Libya
  2. Student, Department of Chemistry, University of Benghazi, Benghazi, Libya

Abstract

Inflammation diseases still threaten humanity everywhere. For which there is always a continuous demand for immediate medication, the so-called anti-inflammatory drug. Anti-inflammatory organic compounds are either of natural origin or synthetic. Many drugs represent the main constituent of plants. Turmeric, ginger, garlic, spinach, broccoli, ginseng, blueberries, clove, Aloe Vera and pineapple all are plants almost rich in anti-oxidant and flavonoids that reduce inflammation. Researchers still have spent decades of years exploring compounds that are known for their anti-inflammatory effect and hence inventing similar synthetic analogues, spending billions of dollars for research. Nowadays, artificial intelligence (AI) is taking part in the invention of new drugs in a comparatively short time and with lower price. Of course, there are plenty of synthetic drugs which can not be covered in this article but we will focus our attention on choosing the most common anti-inflammatory drugs used in Libya such as ibuprofen, diclofenac, and ketoprofen in addition to the other frequently used drugs such as aspirin and naproxen. The use of these along with other non-steroidal anti-inflammatory drugs (NSAIDs) is widespread, although expensive, for conditions like headaches, muscle injuries, and dental pain. We will also show their chemical structure, the method of their synthesis, their pharmaceutical importance, and their side effects.

Keywords: Anti-inflammatory Drug, Artificial Intelligence, Headache, Injuries, Turmeric.

How to cite this article:
Khalid M. Darwish, Ehab El-Hawary. Organic Compounds as Anti-inflammatory Agents, Natural and Synthetic. Research & Reviews: A Journal of Drug Design & Discovery. 2025; 13(01):-.
How to cite this URL:
Khalid M. Darwish, Ehab El-Hawary. Organic Compounds as Anti-inflammatory Agents, Natural and Synthetic. Research & Reviews: A Journal of Drug Design & Discovery. 2025; 13(01):-. Available from: https://journals.stmjournals.com/rrjoddd/article=2025/view=234356


References

1. Ravi Kant Upadhyay. Anti-inflammatory activity of plant-derived natural bio-organic ingredients: A review, International Journal of Green Pharmacy, 2025, 19(2):65
2. Farnoosh Saadati, Amir Modarresi Chahardehi, Negar Jamshidi, Nazanin Jamshidi and Darioush Ghasemi. Coumarin: A natural solution for alleviating inflammatory disorders, Current Research in Pharmacology and Drug Discovery , 2024, 7, 100202
3. Dong-Oh Moon. Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management, community Int. J. Mol. Sci. 2024, 25, 2911.
4. Ling Zheng, Scott J. Howell, Denise A. Hatala, Kun Huang, and Timothy S. Kern.Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy, Diabetes, 2007, 56, 337-345
5. Abdulrahman A Alsimaree, Recent Advances On Antiproliferative and Anti-
inflammatory Potential Of Pyrazoline Derivatives, Biointerface Research in Applied Chemistry, 2025, 15(2): 16
6. Vaishnavi Mali , Geetanjali Patil , and Sariya Shaikh. international journal of innovative research in technology, 2025, 12 (7): 2349-6002
7. Julie Jurenka. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa. A preclinical and clinical research, Alternative Medicine Review: a Journal of Clinical Therapeutic, 2009, 14(2):141-53
8. Pabon, H. J. J., 1964. Synthesis of curcumin and related compounds: Recl. Trav. Chim. Pays-Bas. 83, 379–386
9. Iryna Kravchenko, Lidiya Eberle, Mariia Nesterkina, Alona Kobernik. Anti-inflammatory and analgesic activity of ointment based on dense ginger extract, (Zingiber officinale), J. Herbmed Pharmacol. 2019; 8(2): 126-132.
10. Arman Mahmud Khan, Md. Arman Sharif, Rahagir Salekeen, Md. Hafijur Rahman, Sakib Mahmud, Partha Biswas, Md. Nazmu Hasan, Kazi Mohammed Didarul Islam, Md. Morsaline Billah, Md. Emdadul Islam. In vitro and in silico investigation of garlic’s (Allium sativum) bioactivity against 15-lipoxygenase mediated inflammopathies, J. Herbmed Pharmacol. 2023; 12(2): 283-298.
11. Yuta Morishita, Emi Saito, Eri Takemura, Ryoma Fujikawa, Ryohei Yamamoto,
Masanori Kuroyanagi, Osamu Shirota, And Norio Muto. Flavonoid glucuronides isolated from spinach inhibit IgE-mediated degranulation in basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice, OAT, 2015, DOI: 10.15761/IMM.1000119
12. A.M.A. Hashem, Hanaa Abuzeid, Martin Winter, and Christian M. Julien. Synthesis of High Surface Area α-KyMnO2 Nanoneedles Using Extract of Broccoli as Bioactive Reducing Agent and Application in Lithium Battery, Materials, 2020, 13(6), 1269
13. Ze-Yu Shi, Jin-Zhang Zeng, Alice Sze Tsai Wong. Chemical Structures and Pharmacological Profiles of Ginseng Saponins, Molecules 2019, 24(13), 2443
14. Seema Patel. Blueberry as functional food and dietary supplement: The natural way to ensure holistic health, Mediterranean Journal of Nutrition and Metabolism, 2014, 7, 133–143
15. Magdalena Ulanowska. Biological Properties and Prospects for the Application of Eugenol—A Review, Int. J. Mol. Sci. 2021, 22(7), 3671
16. Khadija Khaldoune, Naima Fdil, Mustapha Ait Ali. Exploring Aloe vera: A comprehensive review on extraction, chemical composition, biological effects, and its utilization in the synthesis of metallic nanoparticles, Biocatalysis and Agricultural Biotechnology, 2024, 27, 103052
17. Jun Hu, Han Lin, Jia Shen, Jiaqi Lan, Chao Ma, Yunan Zhao, Fan Lei, Dongming Xing, and Lijun Du. Developmental toxicity of orally administered pineapple leaf extract in rats, Food and Chem. Toxicology, 2011, 49, 1455-1463
18. Mmurad Abualhasan, Mohyeddin Assali, Nidal Jaradat, Rana Tarayra, Aseel Hamdan, Rula Ardah, Abdel nasr Zaid. Synthesis and formulation of ibuprofen pro-drugs for enhanced transdermal absorption, International Journal of Pharmacy and Pharmaceutical Sciences, 2015, 7(2): 352-354
19. Aymen Labidi. Diclofenac Synthesis, Organic Chemistry-Organometallic Chemistry, 2021, 1, 1-3
20. Sonawane, H. R.; Bellur, N. S.; Kulkarni, D. G.; Ayyangar, N. R. Tetrahedron 1994, 50, 1243.
21. Carolina Ramminger, Danilo Zim, Vanusa R. Lando, Viviane Fassina and Adriano L. Monteiro. Transition-Metal Catalyzed Synthesis of Ketoprofen, J. Braz. Chem. Soc., 2000, 11(2):105-111.
22. Klein , D. (2015). Organic Chemistry, (2nded.). USA: John Wiley & Sons, Inc.
23. Mena, Sara Santiago, Iluminada Gallardo, Gonzalo Guirado. Sustainable and efficient electrosynthesis of naproxen using carbon dioxide and ionic liquids, Chemosphere, 2020, 245, 125557


Ahead of Print Subscription Review Article
Volume 13
01
Received 03/12/2025
Accepted 14/12/2025
Published 15/12/2025
Publication Time 12 Days


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