Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking Approach

Year : 2026 | Volume : 17 | 01 | Page :
    By

    Harshitha Lakshmi N,

  1. Student, Department of Biotechnology, Ramaiah Institute of Technology, Bengaluru, Karnataka, India

Abstract

Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking ApproachGlioneuronal tumors and gliomas are grade I tumors classified by the World Health Organization (WHO). They typically grow slowly and primarily affect infants, children, and teenagers, but can also occur in adults. They mostly cause seizures caused by gangliomas. Most current treatments include surgery and radiotherapy. Since this disease affects children, the current treatments may cause complications. Andrographis paniculata is a medicinal plant that is native to the Indian subcontinent, some parts of China, and Southeast Asia. It has lance-shaped leaves with white flowers with purple streaks. It has short, upright, and branching stems. It has been extensively used in Indian and Chinese traditional medicine. It has anti-inflammatory, antibacterial, hepatoprotective, anti-tumor, and immunomodulatory qualities. Its phytocompounds can suppress the growth of tumor cells. In this study, I explore using Andrographis paniculata phytocompounds against Glioneuronal and glioma tumors. This study explores the in situ and molecular docking analysis. The in-situ analysis was done by SwissADME. The molecular docking was done using the PyRx tool using Autodock Vina software. The Anti-apoptotic protein (Bcl-xl) inhibits programmed cell death. Similarly, Phosphoinositide 3-Kinase (PI3K) is an important signalling pathway that is dysregulated in the case of a tumor. These two proteins were docked against the Andrographis paniculata phytocompounds. The phytocompounds 5-Hydroxy-7,8-dimethoxyflavone, Andrographin, Myristic acid, and Carvacrol showed excellent binding affinity to Bcl-xl and PI3K. Then the protein-phytocompound complex was visualized in Biovia DS software. This study can be further continued by performing molecular dynamics analysis and further in vitro analysis to further understand the therapeutic effect of Andrographis paniculata against Glioneuronal and Gliomas tumors.

Keywords: Glioneuronal tumor, gliomas, in-silico analysis, molecular docking, Andrographis paniculata, ADME analysis,PI3K and Bcl-xL.

How to cite this article:
Harshitha Lakshmi N. Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking Approach. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 17(01):-.
How to cite this URL:
Harshitha Lakshmi N. Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking Approach. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 17(01):-. Available from: https://journals.stmjournals.com/rrjops/article=2025/view=232775


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Ahead of Print Subscription Review Article
Volume 17
01
Received 02/11/2025
Accepted 15/11/2025
Published 21/11/2025
Publication Time 19 Days
110

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