A Comprehensive Review of Nutritional Supplements

Year : 2025 | Volume : 17 | Issue : 01 | Page :
    By

    B. Hariharan,

  • R. Mahalakshmi,

  • A. Mohamed kaif,

  • J. Thamaraiselvan,

  • M. Varshini,

  • P. Sankar,

  • S. Anbazhagan,

  1. Student, Department of Pharmacy, Surya School of Pharmacy, Villupuram, Tamil Nadu, India
  2. Student, Department of Pharmacy, Surya School of Pharmacy, Villupuram, Tamil Nadu, India
  3. Student, Department of Pharmacy, Surya School of Pharmacy, Villupuram, Tamil Nadu, India
  4. Student, Department of Pharmacy, Surya School of Pharmacy, Villupuram, Tamil Nadu, India
  5. Student, Department of Pharmacy, Surya School of Pharmacy, Villupuram, Tamil Nadu, India
  6. Associate Professor, Department of Pharmaceutical Chemistry, Surya School of Pharmacy, Villupuram, Tamil Nadu, India
  7. Principal, Department of Chemistry, Surya School of Pharmacy, Villupuram, Tamil Nadu, India

Abstract

The role of nutrition and nutraceuticals in human health and disease, covering macronutrients, micronutrients, organic acids, trace and macro minerals, vitamins, and bioactive compounds. It outlines biochemical structures, dietary sources, metabolism, physiological functions, and deficiency states of carbohydrates, proteins and amino acids, and fats. Key organic acids, choline, and taurine are described for their metabolic and digestive roles. The document evaluates dietary supplements, functional foods, nutraceuticals, designer foods, and medicinal foods, and discusses regulatory and safety challenges in supplement use. Evidence for nutraceutical applications is surveyed across cardiovascular disease, non-alcoholic fatty liver disease, cancer, obesity, osteoarthritis, diabetes, eye and skin health, asthma, neurological disorders, and gynaecological conditions, highlighting mechanisms of action, notable compounds, benefits, limitations, and safety concerns. The conclusion stresses that nutraceuticals complement but do not replace conventional therapies and calls for evidence-based use, quality assurance, regulatory oversight, and personalized integration into healthcare.

Keywords: Nutritional Supplements, Dietary Supplements, Micronutrients, Macronutrients, Trace minerals.

[This article belongs to Research and Reviews: A Journal of Pharmaceutical Science ]

How to cite this article:
B. Hariharan, R. Mahalakshmi, A. Mohamed kaif, J. Thamaraiselvan, M. Varshini, P. Sankar, S. Anbazhagan. A Comprehensive Review of Nutritional Supplements. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 17(01):-.
How to cite this URL:
B. Hariharan, R. Mahalakshmi, A. Mohamed kaif, J. Thamaraiselvan, M. Varshini, P. Sankar, S. Anbazhagan. A Comprehensive Review of Nutritional Supplements. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 17(01):-. Available from: https://journals.stmjournals.com/rrjops/article=2025/view=232710


References

1) López-Torres Hidalgo, J. A critical review of diet supplementation: The good, the bad, and the ugly.Nutrition and Brain Cognitive Sciences. DOI: 10.1097/NBC.0000000000000101
2) Niculescu, M. D., & Lupu, D. S Nutritional supplements and cognitive performance: Current perspectives. Nutrients. DOI: 10.3390/nu15153320
3) Skeie, G., Braaten, T., Hjartåker, A., Lentjes, M., Amiano, P., Jakszyn, P., & Lund, E. Use of dietary supplements in the EPIC calibration study. Public Health Nutrition. DOI: 10.1017/S1368980008002299
4) Bailey, R. L., Gahche, J. J., Miller, P. E., Thomas, P. R., & Dwyer, J. T. Why US adults use dietary supplements. JAMA Internal Medicine. DOI: 10.1001/jamainternmed.2013.2299
5) Dickinson, A., MacKay, D., & Wong, A. Consumer attitudes about the role of multivitamins and other dietary supplements: Report of a survey. Nutrition Journal. DOI: 10.1186/s12937-015-0053-9
6) U.S. Food and Drug Administration (FDA). Dietary Supplement Health and Education Act of 1994 (DSHEA). Public Law 103–417. Retrieved from https://www.fda.gov/food/dietary-supplement-products-ingredients/dietary-supplement-health-and-education-act-dshea
7) Ahmed, R., & Khandaker, M. S. Natural products as nutraceutical treatments for neurological disorders: An overview. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 62–69. DOI: 10.5281/zenodo.15226021
8) Dwivedi, S. K., Issar, K., & Tiwari, V. Nutrient Requirements in Health and Disease. In: Handbook of Nutraceuticals. DOI: 10.1007/978-3-030-69677-1_3-1
9) Wenner, B., & Dore, M. Nutrient Classification. In: Nutrition in Pediatrics: Basic Science and Clinical Applications (3rd ed.).
10) Walker, W. A., Watkins, J. B., & Duggan, C. Nutrition in Pediatrics: Basic Science and Clinical Applications. Textbook.
11) Nelson, D. L., & Cox, M. M. Lehninger Principles of Biochemistry (5th ed.). W. H. Freeman. DOI: 10.1007/978-3-662-08289-8
12) Lehninger Principles of Biochemistry (7th ed.). (No DOI available for 7th edition.)
13) (No confirmed author) – Advanced Nutrition & Human Metabolism (7th ed.) Advanced Nutrition and Human Metabolism. (Textbook – no DOI)
14) Awuchi, C. G., & Amagwula, I. O. Biochemistry and Nutrition of Carbohydrates. Global Journal of Research in Agriculture and Life Sciences.
15) Ajomiwe, N., Boland, M., Phongthai, S., Bagiyal, M., Singh, J., & Kaur, L. Protein Nutrition: Understanding Structure, Digestibility, and Bioavailability for Optimal Health. Foods. DOI: 10.3390/foods13111771
16) Millward, D. J. Protein metabolism and related body function: mechanistic approaches and health consequences. Proceedings of the Nutrition Society. DOI: 10.1017/S0029665120007880
17) Calvez J, Azzout-Marniche D, Tomé D. Protein quality, nutrition and health. Front Nutr. 2024 May 28;11:1406618. doi: 10.3389/fnut.2024.1406618.
18) Anastassiadis, S. Large-scale lysine fermentation: ~800,000 tons/year, mainly for animal feed. Recent Patents on Biotechnology. DOI: 10.2174/187220807779813947 (I cleaned the title — if you want the exact original title, send it.)

19) Ikeda, M. Strain improvement of Corynebacterium glutamicum for lysine production; global demand >2 million tons/year. Advances in Biochemical Engineering/Biotechnology. DOI: 10.1007/10_2016_27
20) Moe, P. W. Future directions for energy requirements and food energy values. Journal of Nutrition. DOI: 10.1093/jn/124.suppl_9.1738S
21) Keys, A., & Grande, F. Role of dietary fat in human nutrition. American Journal of Public Health. DOI: 10.2105/AJPH.47.12.1520
22) Holman, R. T. The ratio of trienoic: tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement. Journal of Nutrition. DOI: 10.1093/jn/70.3.405
23) Johnston, P. V., Johnson, O. C., & Kummerow, F. A. Occurrence of trans fatty acids in human tissue. Science. DOI: 10.1126/science.126.3276.698-a
24) Sinclair, H. M. Deficiency of essential fatty acids and atherosclerosis. The Lancet. (No DOI provided — if needed, I can find the exact one.)
25) Brenner, R. R. Role of essential fatty acids in the structure and function of biological membranes. Lipids. DOI: 10.1007/BF02533428
26) Bailey, R. L., West, K. P., & Black, R. E.The epidemiology of global micronutrient deficiencies. Annals of Nutrition and Metabolism. DOI: 10.1159/000371618
27) National Academies of Sciences. Prevention of Micronutrient Deficiencies: Tools for Policymakers and Public Health Workers. National Academies Press. DOI: 10.17226/5962
28) Adil, S., Banday, M. T., Bhat, G. A., Mir, M. S., & Rehman, M. Effect of dietary supplementation of organic acids on performance, intestinal histomorphology, and serum biochemistry of broiler chicken. Veterinary Medicine International. (2010). DOI: 10.4061/2010/479485
29) Wishart, D. S., et al. Human Metabolome Database: Citric Acid (HMDB0000094). Human Metabolome Database (HMDB). (2022).
30) Keys, A., & Grande, F. Role of dietary fat in human nutrition. American Journal of Public Health. DOI: 10.2105/AJPH.47.12.1520
31) Wishart DS, et al. Acetic Acid (HMDB0000042). Human Metabolome Database. 2022.
32) Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutrition Reviews. 2009;67:615–623.
33) Parvez S, Malik KA, Kang SA, Kim HY. Probiotics and their fermented food products are beneficial for health. J Appl Microbiol. 2006;100:1171–1185.
34) Schaffer SW, Jong CJ, Ramila KC. Physiological roles of taurine in heart and muscle. J Biomed Sci. 2010;17(Suppl 1):S2.
35) Silva AM, Oliveira PJ. Malic acid metabolism in health and disease. Int J Mol Sci. 2012;13:7405–7419.
36) Draper J, Fialkowski Revilla MK, Titchenal A. 10.1: Introduction to Trace Minerals. LibreTexts. Licensed under CC BY-NC-SA 4.0.
37) Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19:164–174.
38) Uauy R, Olivares M, Gonzalez M. Essentiality of copper in humans. Am J Clin Nutr. 1998;67(Suppl 5):952S–959S.
39) Zimmermann MB. Iodine deficiency. Endocr Rev. 2009;30:376–408.
40) Rayman MP. Selenium and human health. Lancet. 2012;379:1256–1268.
41) Aschner JL, Aschner M. Nutrients and toxicants: Manganese. Pediatr Res. 2005;57:153–159.
42) Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013;18:144–157.
43) Higdon J, Drake VJ. Molybdenum. Linus Pauling Institute, Oregon State University – Micronutrient Information Center. 2021.
44) Mertz W. Chromium in human nutrition: a review. J Nutr. 1993;123:626–633.
45) Carazo A, Macáková K, Matoušová K, Kujovská Krčmová L, Protti M, Mladěnka P. Vitamin A update: Forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity. Nutrients. 2021;13:1703
46) Hanna M, Jaqua E, Nguyen V, Clay J. B Vitamins: Functions and Uses in Medicine. The Permanente Journal. 2022;26(2):89–97. Doi:10.7812/TPP/21.204
47) Doseděl M, Jirkovský E, Macáková K, Krčmová LK, Javorská L, Pourová J, Mercolini L, Remião F, Nováková L, Mladěnka P, on behalf of The OEMONOM. Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients. 2021;13(2):615. Doi:10.3390/nu13020615
48) Dominguez LJ, Farruggia M, Veronese N, Barbagallo M. Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites. 2021;11(4):255. Doi:10.3390/metabo11040255
49) Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F. The role of vitamin E in human health and some diseases. Sultan Qaboos University Medical Journal. 2014;14(2):e157–e165. Doi:10.18295/2075-0528.1566
50) Andrès E, Lorenzo-Villalba N, Terrade J-E, Méndez-Bailon M. Journal of Clinical Medicine. 2024;13(13):3641. Doi:10.3390/jcm13133641
51) Farag MA, Abib B, Qin Z, Ze X, Ali SE. Dietary macrominerals: Updated review of their role and orchestration in human nutrition throughout the life cycle with sex differences. Curr Res Food Sci. 2023;6:100450. doi:10.1016/j.crfs.2023.100450
52) Signorelli GC, Bianchetti MG, Jermini LMM, Agostoni C, Milani GP, Simonetti GD, et al. Dietary chloride deficiency syndrome: Pathophysiology, history, and systematic literature review. Nutrients. 2020;12(11):3436. doi:10.3390/nu12113436
53) Vannucci L, Fossi C, Quattrini S, Guasti L, Pampaloni B, Gronchi G, et al. Calcium intake in bone health: A focus on calcium-rich mineral waters. Nutrients. 2018;10(12):1930. doi:10.3390/nu10121930
54) Itkonen ST, Lamberg-Allardt C. Phosphorus – A scoping review for Nordic Nutrition Recommendations 2023. Food Nutr Res. 2023;67:10318. doi:10.29219/fnr.v67.10318
55) Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M, et al. Magnesium status and stress: The vicious circle concept revisited. Nutrients. 2020;12(12):3672. doi:10.3390/nu12123672
56) Mente A, O’Donnell M, Yusuf S. Sodium intake and health: What should we recommend based on the current evidence? Nutrients. 2021;13(9):3232. doi:10.3390/nu13093232
57) D’Elia L. Potassium intake and human health. Nutrients. 2024;16(6):833. doi:10.3390/nu16060833
58) Chintale AG, Kadam VS, Sakhare RS, Birajdar GO, Nalwad DN. Role of nutraceuticals in various diseases: A comprehensive review. Int J Res Pharm Chem. 2013;3(2):2231–2781.
59) Tappia PS, Shah AK, Dhalla NS. The efficacy of vitamins in the prevention and treatment of cardiovascular disease. Int J Mol Sci. 2024;25(18):9761. doi:10.3390/ijms25189761
60) Del Ben M, Polimeni L, Baratta F, Pastori D, Angelico F. The role of nutraceuticals for the treatment of non-alcoholic fatty liver disease. Br J Clin Pharmacol. 2017;83(1):88–95. doi:10.1111/bcp.12899.
61) Maida DuricSugas Sivanesan, Marica BakovicFirst Phosphatidylcholine functional foods and nutraceuticals: A potential approach to prevent non-alcoholic fatty liver disease published: 10 April 2012https://doi.org/10.1002/ejlt.201100350
62) Aggarwal P, Dutta G, Shaurya R, Rajendran V, Thirunavukkarasu P, Charan J, Kumar T. Unlocking the Potential of Nutraceuticals in Cancer Chemotherapy: A Comprehensive Review. Cureus. 2025 Aug 4;17(8):e89328. doi: 10.7759/cureus.89328.
63) Maiuolo J, Gliozzi M, Carresi C, Musolino V, Oppedisano F, Scarano F, Nucera S, Scicchitano M, Bosco F, Macri R, Ruga S, Cardamone A, Coppoletta A, Mollace A, Cognetti F, Mollace V. Nutraceuticals and Cancer: Potential for Natural Polyphenols. Nutrients. 2021 Oct 27;13(11):3834. doi: 10.3390/nu13113834.

64) Bonetti G, Herbst KL, Donato K, Dhuli K, Kiani AK, Aquilanti B, Velluti V, Matera G, Iaconelli A, Bertelli M. Dietary supplements for obesity. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E160-E168. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2757.
65) Bonetti G, Herbst KL, Dhuli K, Kiani AK, Michelini S, Michelini S, Ceccarini MR, Michelini S, Ricci M, Cestari M, Codini M, Beccari T, Bellinato F, Gisondi P, Bertelli M. Dietary supplements for lipedema. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E169-E173. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2758.
66) Żęgota Z, Goździk J, Głogowska-Szeląg J. EFFICACY OF HERBAL AND NATURALLY-DERIVED DIETARY SUPPLEMENTS FOR THE MANAGEMENT OF KNEE OSTEOARTHRITIS: A MINI-REVIEW. Wiad Lek. 2021;74(8):1975-1983.
67) Vaishya R, Agarwal AK, Shah A, Vijay V, Vaish A. Current status of top 10 nutraceuticals used for Knee Osteoarthritis in India. J Clin Orthop Trauma. 2018 Oct-Dec;9(4):338-348. DOI: 10.1016/j.jcot.2018.07.015
68) Rossino MG, Casini G. Nutraceuticals for the Treatment of Diabetic Retinopathy. Nutrients. 2019 Apr 2;11(4):771. doi: 10.3390/nu11040771.
69) Castro-Castaneda CR, Altamirano-Lamarque F, Ortega-Macías AG, Santa Cruz-Pavlovich FJ, Gonzalez-De la Rosa A, Armendariz-Borunda J, Santos A, Navarro-Partida J. Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology. Nutrients. 2022 Nov 25;14(23):5014. doi: 10.3390/nu14235014.
70) Rohit Sharma, Hetal Amin, PK Prajapati Plant kingdom Nutraceuticals for diabetes Journal of Ayurvedic and Herbal Medicine 2 (6), 224-8, 2016
71) Controlled Trial Authors: Mokgalaboni K, Mashaba R G, Phoswa W N, Lebelo S L. Hyperglycemia and Inflammation in Type 2 Diabetes Mellitus: Quantitative Analysis of Randomized Journal: Nutrients, 2024, Volume 16, Article 4177. DOI: 10.3390/nu16234177
72) Controlled Trials Authors: Kim J, Noh W, Kim A, Choi Y, Kim Y-S. Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized. Journal: International Journal of Molecular Sciences, 2023, Volume 24, Issue 18, Article 13999. DOI: 10.3390/ijms241813999
73) Authors: Pathomwichaiwat T, Jinatongthai P, Prommasut N, Ampornwong K, Rattanavipanon W, Nathisuwan S, et al supplementation on glucose metabolism in diabetes mellitus and metabolic syndrome: An umbrella review and updated meta-analysis. Journal: PLoS ONE, 2023, Volume 18, Issue 7, e0288997. DOI: 10.1371/journal.pone.0288997
74) Skylar A. Souyoul . Katharine P. Saussy. Mary P. Lupo Dermatol Ther (Heidelb) Nutraceuticals: A Review (2018) 8:5–16 https://doi.org/10.1007/s13555-018-0221-x
75) Nutraceuticals and skin health: what are the key benefits and protective properties? Kim Pearson Journal of Aesthetic Nursing 4 (4), 166-171, 2015
76) Januszewski J, Forma A, Zembala J, Flieger M, Tyczyńska M, Dring JC, Dudek I, Świątek K, Baj J. Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why. Medicina (Kaunas). 2023 Dec 29;60(1):68. doi: 10.3390/medicina60010068.
77) Monteleone CA, Sherman AR. Nutrition and asthma. Arch Intern Med. 1997 Jan 13;157(1):23-34.
78) Moreno-Macias H, Romieu I. Effects of antioxidant supplements and nutrients on patients with asthma and allergies. J Allergy Clin Immunol. 2014 May;133(5):1237-44; quiz 1245. doi: 10.1016/j.jaci.2014.03.020.
79) McCarty MF, DiNicolantonio JJ, Lerner A. Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics. J Asthma Allergy. 2021 Jun 15;14:685-701. doi: 10.2147/JAA.S307549.
80) Makkar R, Behl T, Bungau S, Zengin G, Mehta V, Kumar A, Uddin MS, Ashraf GM, Abdel-Daim MM, Arora S, Oancea R. Nutraceuticals in Neurological Disorders. Int J Mol Sci. 2020 Jun 22;21(12):4424. doi: 10.3390/ijms21124424.
81) Ciebiera M, Esfandyari S, Siblini H, Prince L, Elkafas H, Wojtyła C, Al-Hendy A, Ali M. Nutrition in Gynecological Diseases: Current Perspectives. Nutrients. 2021 Apr 2;13(4):1178. doi: 10.3390/nu13041178.
82) Nutrition in Gynecological Diseases: Current Perspectives. Nutrients 2021, 13, 1178. https://doi.org/10.3390/nu13041178

Regular Issue Subscription Review Article
Volume 17
Issue 01
Received 28/10/2025
Accepted 05/11/2025
Published 20/11/2025
Publication Time 23 Days
150

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