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Sarah Mohammed Abed Alwan,
Nagham Mahmood Aljamali2,
- Lecturer, Chemistry Field, Holy Karbala Education Directorate, Karbala, Iraq
- Professor, Department of Chemistry, Synthetic Organic Chemistry, Karbala, Iraq
Abstract
Azo compounds are used as intermediates in the preparation of many well-known and diverse organic derivatives. Cyclical or related azo derivatives, such as triazoles and thiophenes, possess useful applications in medicinal and pharmaceutical chemistry. Thiophene compounds and their derivatives have demonstrated a variety of biological activities, including antibacterial, antifungal, anti-tuberculosis, anti-inflammatory, analgesic, sedative, and hypnotic properties, immunosuppressive, and antihypertensive properties. Furthermore, thiophene derivatives can be used in the treatment of gastrointestinal disorders, diabetes prevention, and antioxidant activities. Most thiophene and triazole derivatives are of the most importance because they form part of the structure of some important medical compounds, such as drugs used for anesthesia, muscle relaxation, and sedation in animals. They are also used as anxiolytics and muscle relaxants. In this study, and in continuation of the work of previous researchers, we have prepared several cyclic compounds of thiophene and triazole, and they were linked to other rings, as well as linked to azo groups by forming the carbanion ion and attacking the azo group through the coupling reaction, and then the compounds were identified by spectroscopic means and other applied studies to know the effectiveness of the prepared compounds like fluorescence study and measurements of absorption and emission of molecules in optical analysis.
Keywords: thiophene, triazole, azo, coupling, hetero, five membered, six, seven membered
Sarah Mohammed Abed Alwan, Nagham Mahmood Aljamali2. Formation, Organic Investigation, Fluorescence Study of New Cyclic Derivatives of Thiophane-Triazole Compounds. Emerging Trends in Chemical Engineering. 2025; 12(03):-.
Sarah Mohammed Abed Alwan, Nagham Mahmood Aljamali2. Formation, Organic Investigation, Fluorescence Study of New Cyclic Derivatives of Thiophane-Triazole Compounds. Emerging Trends in Chemical Engineering. 2025; 12(03):-. Available from: https://journals.stmjournals.com/etce/article=2025/view=228244
References
- Abe M, Shimizu A, Yokoyama Y, Takeuchi Y, Ishikawa O. A possible inhibitory action of diaminodiphenyl sulfone on tumour necrosis factor-α production from activated mononuclear cells on cutaneous lupus erythematosus. Clin Exp Dermatol. 2008;33(6):759-63.
- Ahmad RA, Rogers HJ. Pharmacokinetics and protein binding interactions of dapsone and pyrimethamine. Br J Clin Pharmacol. 1980;10(6):519-24.
- Al-Said MS, Ghorab MM, Nissan YM. Dapson heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties. Chem Cent J. 2012;6:64.
- Altagracia M, Monroy-Noyola A, Osorio-Rico L, Kravzov J, Varado-Calvillo R, Manjarrez-Marmolejo J, et al. Dapsone attenuates kainic acid-induced seizures in rats. Neurosci Lett. 1994;176(1):52-4.
- Anderson R, Gatner EM, van Rensburg CE, Grabow G, Imkamp FM, Kok SK, et al. In vitro and in vivo effects of dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy. Antimicrob Agents Chemother. 1981;19(3):495-503.
- Anderson R. Enhancement by clofazimine and inhibition by dapsone of production of prostaglandin E2 by human polymorphonuclear leukocytes in vitro. Antimicrob Agents Chemother. 1985;27(2):257-62.
- Mahmood AN. Synthesis and chemical identification of macro compounds of thiazol and imidazol. Res J Pharm Technol. 2015;8(1):78-84. doi:10.5958/0974-360X.2015.00016.5.
- Ashurst JV, Wasson MN, Hauger W, Fritz WT. Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. J Am Osteopath Assoc. 2010;110(1):16-20.
- Barranco VP. Inhibition of lysosomal enzymes by dapsone. Arch Dermatol. 1974;110(4):563-6.
- Beiguelman B, Pisam RC. Effect of DDS on phytohemagglutinin-induced lymphocyte transformation. Int J Lepr Other Mycobact Dis. 1974;42(4):412-5.
- Mahmood AN. Synthesis and biological study of hetero (atoms and cycles) compounds. Der Pharma Chem. 2016;8(6):40-8.
- Berlow BA, Liebhaber MI, Dyer Z, Spiegel TM. The effect of dapsone in steroid-dependent asthma. J Allergy Clin Immunol. 1991;87(3):710-5.
- Bernstein JE, Lorincz AL. Sulfonamides and sulfones in dermatologic therapy. Int J Dermatol. 1981;20(2):81-8.
- Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011;19(12):3717-31.
- Blasum C. Untersuchung zur Beinflussung der Interleukin-8-Spiegel in Lipopolysaccharid-stimulierten Vollblut gesunder Probanden durch in der Dermatologie angewandte antiinflammatorische Pharmaka mit antioxidativer Potenz [dissertation]. Dresden: Technical University, University Hospital, Department of Dermatology; 1998.
- Boehm I, Bauer R, Bieber T. Urticaria treated with dapsone. Allergy. 1999;54(7):765-6.
- Mahmood AN. Origination of macrocyclic formazan with macrocyclic sulfazan and triazan as innovated compounds and compared their efficiency against breast cancer. Open Access J Biomed Sci. 2022;4(1):OAJBS.ID.000383. doi:10.38125/OAJBS.000383.
- Perro A, Reculusa S, Bourgeat-Lami E, Duguet E, Ravaine S. Synthesis of hybrid colloidal particles: from snowman-like to raspberry-like morphologies. Colloids Surf A Physicochem Eng Asp. 2006;284(1-3):78-83.
- Husien NSM, Aljamali NM. Designation of nano-analytical reagents and evaluation of nano-applications. J Adv Res Fluid Mech Therm Sci. 2024;116(2):27-40.
- Bonney RJ, Wightman PD, Dahlgren ME, Sadowski SJ, Davies P, Jensen N, et al. Inhibition of the release of prostaglandins, leukotrienes and lysosomal acid hydrolases from macrophages by selective inhibitors of lecithin biosynthesis. Biochem Pharmacol. 1983;32(3):361-6.
- Booth SA, Moody CE, Dahl MV, Herron MJ, Nelson RD. Dapsone suppresses integrin-mediated neutrophil adherence function. J Invest Dermatol. 1992;98(2):135-40.
- Bordin L, Fiore C, Zen F, Coleman MD, Ragazzi E, Clari G. Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding. Br J Pharmacol. 2010;161(6):1186-99.
- Wang C, Yan J, Du M, Burlison JA, Li C, Sun Y, et al. One-step synthesis of indirubins by reductive coupling of isatins with KBH4. Tetrahedron. 2017;73(19):2780-5. doi:10.1016/j.tet.2017.03.077
- Lattuada M, Hatton TA. Synthesis, properties and applications of Janus nanoparticles. Nano Today. 2011;6(3):286-308.
- Song Y, Chen S. Janus nanoparticles: preparation, characterization, and applications. Chem Asian J. 2014;9(2):418-30.
- Liang F, Zhang C, Yang Z. Rational design and synthesis of Janus composite. Adv Mater. 2014;26(40):6944-9.
- Perro A, Meunier F, Schmitt V, Ravaine S. Production of large quantities of “Janus” nanoparticles using wax-in-water emulsions. Colloids Surf A Physicochem Eng Asp. 2009;332(1):57-62.
- Imd KA, Hsanen KA, Nagham MA. Invention of (Gluta.Sulfazane-Cefixime) compounds as inhibitors of cancerous tumors. J Cardiovasc Dis Res. 2020;11(2):44-55. doi:10.31838/jcdr.2020.11.02.09
- AbdAli M, Mahmood NA. Synthesis, spectral, bioassay, chromatographic studying of new imidazole reagents via three components reaction. NeuroQuantology. 2021;19(7):115-22. doi:10.14704/nq.2021.19.7.NQ21092
- Wahyudi S, Vardiansyah NR, Setyorini PH. Effect of blood perfusion on temperature distribution in the multilayer of the human body with interstitial hyperthermia treatment for tumour therapy. CFD Lett. 2022;14(6):102-14. doi:10.37934/cfdl.14.6.102114
- Mahmood AJ, Mahmood NA, Jwad SM. Development and preparation of ciprofloxacin drug derivatives for treatment of microbial contamination in hospitals and environment. Indian J Forensic Med Toxicol. 2020;14(2):1115-22.
- Mahmood NA. Synthesis of antifungal chemical compounds from fluconazole with (pharma-chemical) studying. Res J Pharm Biol Chem Sci. 2017;8(3):564-73.
- Pradhan S, Xu LP, Chen S. Janus nanoparticles by interfacial engineering. Adv Funct Mater. 2007;17(14):2385-92.
- Matheus ME, de Almeida Violante F, Garden SJ. Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line. Eur J Pharmacol. 2007;556(1-3):200-6.
- Pera-Titus M, Leclercq L, Clacens JM, De Campo F, Nardello-Rataj V. Pickering interfacial catalysis for biphasic systems: from emulsion design to green reactions. Angew Chem Int Ed Engl. 2015;54(7):2006-21.
- Fan Z, Tay A, Pera-Titus M, Zhou WJ, Benhabbari S, Feng X. Pickering interfacial catalysts for solvent-free biomass transformation: physicochemical behavior of non-aqueous emulsions. J Colloid Interface Sci. 2014;427:80-90.
- Hsanen KA, Aseel MJ, Mahmood NA. Synthesis of drug derivatives as inhibitors of cancerous cells. Biochem Cell Arch. 2020;20(2):4211-7.
- Mehta SL, Manhas N, Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev. 2007;54(1):34-66.
- Faria J, Ruiz MP, Resasco DE. Phase-selective catalysis in emulsions stabilized by Janus silica-nanoparticles. Adv Synth Catal. 2010;352(14-15):2359-64.
- Rasool SR, Mahmood NA, Jassim AA. Guanine substituted heterocyclic derivatives as bioactive compounds. Biochem Cell Arch. 2020;20(Suppl 2):3651-5. Available from: https://connectjournals.com/03896.2020.20.3651
- Mahmood NA, Alfatlawi IO. Synthesis of sulfur heterocyclic compounds and study of expected biological activity. Res J Pharm Technol. 2015;8(9):1225-42. doi:10.5958/0974-360X.2015.00224.3
- d’Alnoncourt RN, Csepei LI, Hävecker M, Girgsdies F, Schuster ME, Schlögl R, et al. The reaction network in propane oxidation over phase-pure MoVTeNb M1 oxide catalysts. J Catal. 2014;311:369-85. doi:10.1016/j.jcat.2013.12.008
- Mahmood NA, Jawd SM, Zainab MJ, Alfatlawi IO. Inhibition activity of (Azo–acetyl acetone) on bacteria of mouth. Res J Pharm Technol. 2017;10(6):1683-6. doi:10.5958/0974-360X.2017.00297.9
- Abdul Aal RH, Alkaabi SJ. Inhibition activity of silver nanoparticles (AgNPs) biosynthesized by Ziziphus spina-Christi leaf extract against local pathogenic bacterial isolates. Al-Harf J. 2024;22(Aug):1-10.
- Mahmood NA. Inventing of macrocyclic formazan compounds with their evaluation in nano-behavior in the scanning microscope and chromatography. Biomed J Sci Tech Res. 2022;41(3):32783-92. doi:10.26717/BJSTR.2022.41.006616
- Alfatlawi IO, Nuha SS, Zainab MJ, Aljamali NM. Synthesis of new organic compounds via three components reaction with studying of identification, thermal behavior, bioactivity on bacteria of teeth. J Glob Pharm Technol. 2017;11(9):157-64.
- Mokrani T, van Reenen A, Amer I. Molecular weight and tacticity effect on morphological and mechanical properties of Ziegler–Natta catalyzed isotactic polypropylenes. Polímeros. 2015;25(6):556-63. doi:10.1590/0104-1428.2158

Emerging Trends in Chemical Engineering
| Volume | 12 |
| 03 | |
| Received | 12/06/2025 |
| Accepted | 17/07/2025 |
| Published | 27/09/2025 |
| Publication Time | 107 Days |
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