Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2025 | Volume : 3 | 02 | Page :
    By

    Vyomal Chaudhari,

  • Jeni R. Patel,

  1. Department of Biology, The Patidar Gin Science College, Bardoli, Gujarat, India
  2. Department of Biology, The Patidar Gin Science College, Bardoli, Gujarat, India

Abstract

Blood Cancer, also popular with name ‘Hematologic cancer’ have variety of types: Leukaemia, Lymphoma, Myeloma, uncontrolled multiplication of blood cells mainly affecting to bone marrow and blood cells (White Blood Cells). Lymphoma, originating from lymphatic system resulted in uncontrolled growth and instead of normal apoptosis development of tumor. Myeloma, uncontrolled formation of malignant plasma cells leads disrupting production of healthy blood cells. This situation creates variety of diseases like anaemia, thrombocytopenia, and leukopenia. Leukaemia and lymphomas involved abnormal growth and survival of cancerous blood cells resulted due to mutation in RAS signalling. 5p9j protein (RAS protein, a small GTPase molecule) is responsible for this mutation in signalling pathway. To cure these types of diseases, In Silico analysis using multi-target molecular docking method was used. In present study, total 13 bioactive compounds of source medicinal plant named Abies grandis were used to explore top three Phytocompounds and their anticancer potential against malignant activity of 5p9j protein.

Keywords: Molecular docking, RAS signalling, Abies grandis, Lymphoma, Myeloma, SwissADME analysis, Biovia Discovery studio visualization

How to cite this article:
Vyomal Chaudhari, Jeni R. Patel. Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein. International Journal of Molecular Biotechnological Research. 2025; 03(02):-.
How to cite this URL:
Vyomal Chaudhari, Jeni R. Patel. Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein. International Journal of Molecular Biotechnological Research. 2025; 03(02):-. Available from: https://journals.stmjournals.com/ijmbr/article=2025/view=227192


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Ahead of Print Subscription Original Research
Volume 03
02
Received 21/05/2025
Accepted 06/07/2025
Published 15/09/2025
Publication Time 117 Days
240

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