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nThis is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.n
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Amar Mohite, Rohan Sharadanand Phatak, Vyankatesh R Dharanguttikar, Swapnali Thorat, Atul R Chopade, Jayant Rajaram Pawar,
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- Research Associate, Assistant Professor, Assistant Professor, Assistant Professor, Associate Professor, Associate Professor, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Department of Pharmacognosy, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, Maharshtra, Maharshtra, Maharshtra, Maharshtra, Maharshtra, India, India, India, India, India, India
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Abstract
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nPolymer chemistry enables the stabilization and sustained release of herbal actives, critical for topical therapeutic applications. This study explores a novel process for preparing a stable, sustained-release topical composition of Euphorbia tithymaloides, leveraging polymer-based systems. Ethanolic extract (50 mg) of the plant, rich in unstable sugar moieties (e.g., D-ribose) and sterols (e.g., stigmasterol), is encapsulated within a phospholipid matrix of phosphatidylcholine (50–100 mg) and cholesterol (50–100 mg). This lipid-polymer complex, formed via rotary evaporation at 45°C and hydrated with phosphate buffer saline (pH 7.4), yields a vesicular suspension with 0.2 µm particles after sonication. The suspension’s stability stems from phospholipid bilayer assembly, protecting labile phytocompounds from Lewis acid (dichloromethane) degradation. Integrated into a transdermal patch with polyvinyl alcohol (PVA) and ethyl cellulose (EC), plasticized by polyethylene glycol (PEG) and enhanced by dimethyl sulfoxide (DMSO), the system achieves a 90-day shelf life and 89.40% drug release over 12 hours. Polymer-polymer interactions—PVA’s hydrophilic chains and EC’s hydrophobic backbone—modulate release kinetics, while PEG reduces matrix rigidity (Tg ~ -60°C). The patch (2×2 cm²) ensures uninterrupted drug-skin contact, ideal for chronic inflammation. FT-IR confirms no adverse drug-polymer interactions, and stability data (pH 5.4, 98.25% drug content at 90 days) validate the composite’s robustness. This work underscores polymer chemistry’s role in crafting herbal delivery systems, with potential for synthetic polymer enhancements (e.g., polycaprolactone) to further optimize performance.nn
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Keywords: Polymer Chemistry, Phospholipid Vesicles, Transdermal Patch, Euphorbia tithymaloides, Sustained Release, Polymer Composites, Stability.
n[if 424 equals=”Regular Issue”][This article belongs to Journal of Polymer and Composites ]
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nAmar Mohite, Rohan Sharadanand Phatak, Vyankatesh R Dharanguttikar, Swapnali Thorat, Atul R Chopade, Jayant Rajaram Pawar. [if 2584 equals=”][226 wpautop=0 striphtml=1][else]Polymer Chemistry in Sustained-Release Herbal Composites: Designing a Stable Euphorbia tithymaloides Topical System with Phospholipid and Polymer Matrices[/if 2584]. Journal of Polymer and Composites. 30/08/2025; 13(06):-.
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nAmar Mohite, Rohan Sharadanand Phatak, Vyankatesh R Dharanguttikar, Swapnali Thorat, Atul R Chopade, Jayant Rajaram Pawar. [if 2584 equals=”][226 striphtml=1][else]Polymer Chemistry in Sustained-Release Herbal Composites: Designing a Stable Euphorbia tithymaloides Topical System with Phospholipid and Polymer Matrices[/if 2584]. Journal of Polymer and Composites. 30/08/2025; 13(06):-. Available from: https://journals.stmjournals.com/jopc/article=30/08/2025/view=0
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| Volume | 13 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 06 | |
| Received | 12/03/2025 | |
| Accepted | 16/04/2025 | |
| Published | 30/08/2025 | |
| Retracted | ||
| Publication Time | 171 Days |
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