Electrospun Antibacterial Polymer Composite Scaffolds Incorporating Silver Nanoparticles for Enhanced Wound Healing

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Year : 2025 | Volume : 13 | 05 | Page : –
    By

    Kumaresan.T,

  • Subhashini.S,

  • M.Chrispin Das,

  • P.Senthilkumar,

  • Chandra Sekhar K,

  • P.Janagarathinam,

  • SUMANTH S,

  • Denis R,

  1. Lecturer (Senior Grade), Mechanical Engineering, PSG Polytechnic College, , India
  2. Assistant Professor (Senior Grade), Assistant Professor (Senior Grade), Department of Computer Science and Engineering, B S Abdur Rahman Crescent Institute of Science and Technology,Chennai, Tamil Nadu, India
  3. Associate Professor, Department of Mechanical Engineering, St.Joseph’s Institute of Technology, OMR, Chennai, Tamil Nadu, India
  4. Associate Professor, Department of Mechanical Engineering, Nehru Institute of Engineering and Technology, Thirumalayampalayam, Coimbatore, Tamil Nadu, India
  5. Assistant professor, Dept of Information Technology, Srkr engineering college, Bhimavaram, Andhra Pradesh, India
  6. Assistant Professor, Department of Mechanical Engineering, SNS College of Technology, Coimbatore, Tamil Nadu, India
  7. Associate Professor, Department of Computer Science and Applications, Government College for Women, Kolar, Karnataka, India
  8. Assistant Professor, Mount Carmel College Autonomous Bengaluru, Karnataka, India

Abstract

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The current work was concerned with the synthesis and the characterization of electrospun polycaprolactone (PCL)/chitosan-based nanofiber scaffolds with silver nanoparticles (AgNPs) loading for improved antibacterial and biological potential. Electrospinning has been used for manufacturing uniform nanofibers with regulated morphology and optimized fiber diameter. With respect to the incorporations of AgNPs, varying silver concentrations were used to determine their effects on the fiber structures, activity against the microbes and cells compatibility. With the increased concentration of AgNP, scanning electron microscopy (SEM) showed the dispersion of fibers with decreased diameter. The distribution and distribution of silver in the fibers was detected by EDS and topography analysis. Antibacterial efficacy was determined by zone of inhibition tests and colony-forming unit (CFU) drop studies that were conducted against E. coli and S. aureus. Results showed strong dose-dependent antimicrobial response to the highest effect with significant increase in bacterial inhibitions at increasing AgNPs levels. In addition, porosity measurements showed the scaffold to be appropriate for cellular infiltration. Cell attachment studies with SEM revealed good morphology and spreading of cells on the AgNPs loaded scaffolds implying improved biocompatibility. The addition of PCL/chitosan with silver nanoparticles created an advanced multi-functional system that ensures protection against bacteria while simultaneously delivering the interaction with the cells; this was important in terms of applications for wound healing and tissue engineering. The results show that the controlled inclusion of AgNPs into electrospun nanofibers can be used to achieve effective augmentation of antimicrobial properties without destroying the structural integrity and biocompatibility. According to this study, the AgNP-functionalized scaffolds have the potential to be used for biomedical applications when infection management and tissue regeneration are important.

Keywords: Electrospun nanofibers, Silver nanoparticles, Antibacterial scaffold, PCL/Chitosan, Cell adhesion, Tissue engineering.

How to cite this article:
Kumaresan.T, Subhashini.S, M.Chrispin Das, P.Senthilkumar, Chandra Sekhar K, P.Janagarathinam, SUMANTH S, Denis R. Electrospun Antibacterial Polymer Composite Scaffolds Incorporating Silver Nanoparticles for Enhanced Wound Healing. Journal of Polymer and Composites. 2025; 13(05):-.
How to cite this URL:
Kumaresan.T, Subhashini.S, M.Chrispin Das, P.Senthilkumar, Chandra Sekhar K, P.Janagarathinam, SUMANTH S, Denis R. Electrospun Antibacterial Polymer Composite Scaffolds Incorporating Silver Nanoparticles for Enhanced Wound Healing. Journal of Polymer and Composites. 2025; 13(05):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=0


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Ahead of Print Subscription Original Research
Volume 13
05
Received 14/05/2025
Accepted 21/06/2025
Published 07/07/2025
Publication Time 54 Days
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