Horizons in Neuralgia Care: Addressing Unmet Needs and Future Prospects

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2025 | Volume : 02 | 02 | Page : –
    By

    Pramod Kumar Pathak,

  • Satish Kumar Sarankar,

  1. Research Scholar, Department of Pharmacy, Mansarovar Global University, Sehore,, M.P., India
  2. Professor & Principal, Department of Pharmacy, Mansarovar Global University, Sehore,, M.P., India

Abstract

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Neuralgia refers to intense, sharp, and often chronic pain resulting from damage or irritation to nerves. It is typically characterized by sudden, shooting pain along the course of a nerve, significantly impairing daily functioning and impacting both physical and emotional well-being. Given its intensity and chronic nature, neuralgia presents a complex challenge in clinical management, emphasizing the importance of timely diagnosis and effective intervention to improve patient outcomes. This comprehensive overview covers the underlying causes, types, clinical manifestations, diagnostic strategies, and treatment options for neuralgia. Various etiologies are explored, including nerve compression, viral infections (such as shingles), diabetes, multiple sclerosis, and traumatic injuries, all of which can lead to nerve irritation or damage. The discussion includes distinct forms of neuralgia, such as trigeminal, postherpetic, glossopharyngeal, and occipital neuralgia, each associated with specific pain patterns and nerve involvement that necessitate tailored diagnostic and therapeutic approaches.Clinically, neuralgia is marked by sudden, sharp, and stabbing pain, often triggered or exacerbated by touch, temperature changes, or movement. Symptoms may be intermittent or persistent, complicating the clinical presentation and making diagnosis more challenging. Diagnostic strategies emphasize thorough clinical evaluations, detailed patient histories, and the use of advanced imaging techniques like MRI and CT scans to identify underlying causes. In some cases, nerve conduction studies or electromyography are employed to assess nerve damage or dysfunction. Treatment options range from pharmacological therapies, including anticonvulsants, antidepressants, and analgesics, to interventional approaches like nerve blocks, neuromodulation, and surgical procedures. Each modality is examined in terms of efficacy, limitations, and potential side effects, reinforcing the need for individualized treatment plans based on the specific type and severity of neuralgia. By offering an in-depth exploration of neuralgia’s causes, clinical features, diagnostic methods, and treatment strategies, this article aims to enhance understanding and improve management practices. It also underscores the ongoing need for research into novel and more effective therapies to better address the complexities of neuralgia and reduce its burden on patients.

Keywords: Neuralgia, Peripheral neuropathy, Diagnosis, Treatment, Management.

How to cite this article:
Pramod Kumar Pathak, Satish Kumar Sarankar. Horizons in Neuralgia Care: Addressing Unmet Needs and Future Prospects. International Journal of Brain Sciences. 2025; 02(02):-.
How to cite this URL:
Pramod Kumar Pathak, Satish Kumar Sarankar. Horizons in Neuralgia Care: Addressing Unmet Needs and Future Prospects. International Journal of Brain Sciences. 2025; 02(02):-. Available from: https://journals.stmjournals.com/ijbs/article=2025/view=0


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References

  1. Raja SN, Carr DB, Cohen M, et al. The revised International Association for the Study of Pain definition of pain: Concepts, challenges, and compromises. Pain. 2020;161(9):1976–82.
  2. Wilhour D, Nahas SJ. The neuralgias. Curr Neurol Neurosci Rep. 2018;18(10):69.
  3. Taşci İ, Beydilli İ, Demir CF, Balgetir F, Gönen M, Bakir M. A case of syncopal convulsions triggered by glossopharyngeal neuralgia. Agri. 2021;33:197–9.
  4. Peirs C, Seal RP. Neural circuits for pain: Recent advances and current views. Science. 2016;354(6312):578–84.
  5. De León AM, Garcia-Santibanez R, Harrison TB. Neuropathies due to infections and antimicrobial treatments. Curr Treat Options Neurol. 2023;1–17.
  6. Wijntjes J, Borchert A, van Alfen N. Nerve ultrasound in traumatic and iatrogenic peripheral nerve injury. Diagnostics (Basel). 2020;11(1):30.
  7. Kazamel M, Stino AM, Smith AG. Metabolic syndrome and peripheral neuropathy. Muscle Nerve. 2021;63(3):285–93.
  8. Bhagavati S. Autoimmune disorders of the nervous system: Pathophysiology, clinical features, and therapy. Front Neurol. 2021;12:664664.
  9. Peters J, Staff NP. Update on toxic neuropathies. Curr Treat Options Neurol. 2022;24(5):203–16.
  10. Gambeta E, Chichorro JG, Zamponi GW. Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments. Mol Pain. 2020;16:1744806920901890.
  11. Chen YW, Chuang SK. Botulinum toxin A might be an alternative or adjunct therapy for the treatment of trigeminal and postherpetic neuralgia. J Evid Based Dent Pract. 2017;17:259–61.
  12. Gande AV, Chivukula S, Moossy JJ, Rothfus W, Agarwal V, Horowitz MB, et al. Long-term outcomes of intradural cervical dorsal root rhizotomy for refractory occipital neuralgia. J Neurosurg. 2016;125(1):102–10.
  13. Shah RJ, Padalia D. Glossopharyngeal neuralgia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
  14. Schreiber AK, Nones CF, Reis RC, Chichorro JG, Cunha JM. Diabetic neuropathic pain: Physiopathology and treatment. World J Diabetes. 2015;6(3):432–44.
  15. Fazekas D, Doroshenko M, Horn DB. Intercostal neuralgia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
  16. Leslie SW, Antolak S, Feloney MP, et al. Pudendal neuralgia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
  17. Jensen TS, Finnerup NB. Allodynia and hyperalgesia in neuropathic pain: Clinical manifestations and mechanisms. Lancet Neurol. 2014;13(9):924–35.
  18. Balzani E, Fanelli A, Malafoglia V, Tenti M, Ilari S, Corraro A, et al. A review of the clinical and therapeutic implications of neuropathic pain. Biomedicines. 2021;9(9):1239.
  19. Gadient PM, Smith JH. The neuralgias: Diagnosis and management. Curr Neurol Neurosci Rep. 2014;14(7):459.
  20. Montano N, Conforti G, Di Bonaventura R, Meglio M, Fernandez E, Papacci F. Advances in diagnosis and treatment of trigeminal neuralgia. Ther Clin Risk Manag. 2015;11:289–99.
  21. Keppel Hesselink JM, Schatman ME. Phenytoin and carbamazepine in trigeminal neuralgia: Marketing-based versus evidence-based treatment. J Pain Res. 2017;10:1663–6.
  22. Tikhonov DB, Zhorov BS. Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants. J Gen Physiol. 2017;149:465–81.
  23. Al-Quliti KW. Update on neuropathic pain treatment for trigeminal neuralgia: The pharmacological and surgical options. Neurosciences (Riyadh). 2015;20:107–14.
  24. Patel P, Green M, Tram J, Wang E, Murphy M, Abd-Elsayed AA, et al. Latest advancements in transcutaneous electrical nerve stimulation (TENS) and electronic muscle stimulation (EMS): Revisiting an established therapy with new possibilities. J Pain Res. 2025;18:137–53.
  25. Klowak M, Lau R, Mohammed MN, Birago A, Samson B, Ahmed L, et al. A systematic review of dietary lifestyle interventions for neuropathic pain. J Clin Med. 2024;13(22):6766.
  26. Meaadi J, Obara I, Eldabe S, Nazar H. The safety and efficacy of gabapentinoids in the management of neuropathic pain: A systematic review with meta-analysis of randomised controlled trials. Int J Clin Pharm. 2023;45(3):556–65.
  27. Mitsikostas DD, Moka E, Orrillo E, Aurilio C, Vadalouca A, Paladini A, et al. Neuropathic pain in neurologic disorders: A narrative review. Cureus. 2022;14(2):e22419.
  28. Parmar M, Sharma N, Modgill V, Naidu P. Comparative evaluation of surgical procedures for trigeminal neuralgia. J Maxillofac Oral Surg. 2013;12(4):400–9.
  29. Emery EC, Luiz AP, Wood JN. Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief. Expert Opin Ther Targets. 2016;20(8):975–83.
  30. Mavridis T, Deligianni CI, Karagiorgis G, Daponte A, Breza M, Mitsikostas DD. Monoclonal antibodies targeting CGRP: From clinical studies to real-world evidence—What do we know so far? Pharmaceuticals (Basel). 2021;14(7):700.

Ahead of Print Subscription Review Article
Volume 02
02
Received 28/04/2025
Accepted 23/06/2025
Published 27/06/2025
Publication Time 60 Days

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