Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications

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Year : 2025 | Volume : 13 | 05 | Page :
    By

    Pratik Prakash Somade,

  • Shrinivas K Mohite,

  • Atul R Chopade,

  • Vyankatesh R Dharanguttikar,

  • Swapnali A Thorat,

  1. Tutor, Department of Anatomy, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharshtra, India
  2. Professor, Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Maharshtra, India
  3. Associate Professor, Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Maharshtra, India
  4. Assistant Professor, Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Maharshtra, India
  5. Assistant Professor, Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Maharshtra, India

Abstract

The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely utilized in the pharmaceutical industry to develop advanced drug delivery systems and optimize therapeutic effects. Polymers serve as carriers, stabilizers, and release modulators in drug formulation, ensuring the bioavailability and efficacy of active pharmaceutical ingredients (APIs). This research aims to develop a polymer-supported synthetic strategy for producing benzamide derivatives with potential pharmaceutical applications, particularly as anti-inflammatory agents. The results indicated strong binding affinities, suggesting the potential of these derivatives as effective anti-inflammatory agents. The polymer-supported approach not only improves the physicochemical properties of the final product but also enhances its biological activity, making it a promising candidate for pharmaceutical applications. Overall, this study demonstrates the advantages of polymer-assisted synthesis in medicinal chemistry, providing a robust method for developing bioactive compounds with improved stability and therapeutic potential. Future work will explore in vitro and in vivo evaluations to further validate their pharmacological properties.

Keywords: Polymer Chemistry, Benzamide Derivatives, Anti-inflammatory Agents, Polymeric Supports, FTIR, NMR, Molecular Docking.

How to cite this article:
Pratik Prakash Somade, Shrinivas K Mohite, Atul R Chopade, Vyankatesh R Dharanguttikar, Swapnali A Thorat. Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications. Journal of Polymer and Composites. 2025; 13(05):-.
How to cite this URL:
Pratik Prakash Somade, Shrinivas K Mohite, Atul R Chopade, Vyankatesh R Dharanguttikar, Swapnali A Thorat. Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications. Journal of Polymer and Composites. 2025; 13(05):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=214592


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Ahead of Print Subscription Review Article
Volume 13
05
Received 28/02/2025
Accepted 08/04/2025
Published 24/06/2025
Publication Time 116 Days
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