Stimuli-Responsive Polymers for Drug Release in Targeted Therapy

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2025 | Volume : 13 | 04 | Page : –
    By

    P. M. Gaigole,

  • Sagavkar S. R,

  • Jeetendra Dhamone,

  • Sameer Sawarkar,

  1. , Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharshtra, India
  2. , Department of Pharmaceutics, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharshtra, India
  3. , Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharshtra, India
  4. Associate Professor, Department of Civil Engineering, PCCOER, Ravet, Pune, Maharshtra, India

Abstract

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SRPs, or stimuli-responsive polymers, are becoming a good way to give specific drugs. They let medicines be released in a controlled way. Some of the things that can change these polymers are pH, temperature, light, magnetic fields, and the number of ions present. Some outside signs can make SRPs respond, which helps control how drugs are released. This cuts down on side effects and improves the effectiveness of focused treatments. In the past few years, there have been big steps forward in making SRPs with special groups that let them work when they get into the body. In cancer treatment, pH-sensitive plastics are used to let drugs work in the acidic environment of tumours. In the same way, thermoresponsive polymers can release drugs when the temperature changes, which makes them useful for going after areas that are sick or swollen. This essay talks about how smart release systems (SRPs) work and the newest ways to use them to treat certain drugs. It focusses on how polymers are designed, how they are made, and how they are used in drug delivery systems. The paper also talks about the problems with SRP-based systems, such as their safety, ability to grow, and ability to work with live things. It also suggests ways to fix these issues. Nanoparticles, liposomes, and micelles can be used with SRPs to make drugs breakdown better and be taken more easily by the body.

Keywords: Stimuli-responsive polymers, targeted drug delivery, controlled drug release, polymer design, nanocarriers.

How to cite this article:
P. M. Gaigole, Sagavkar S. R, Jeetendra Dhamone, Sameer Sawarkar. Stimuli-Responsive Polymers for Drug Release in Targeted Therapy. Journal of Polymer and Composites. 2025; 13(04):-.
How to cite this URL:
P. M. Gaigole, Sagavkar S. R, Jeetendra Dhamone, Sameer Sawarkar. Stimuli-Responsive Polymers for Drug Release in Targeted Therapy. Journal of Polymer and Composites. 2025; 13(04):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 13
04
Received 20/03/2025
Accepted 19/05/2025
Published 31/05/2025
Publication Time 72 Days
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