Polysaccharide-Based Hydrogels for Sustained Drug Release in Pharmacology

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Year : 2025 | Volume : 13 | 04 | Page : –
    By

    Ghorpade V.S.,

  • Sameer Sawarkar,

  • Vijaykumar Javanjal,

  • A.U. Rajurkar,

  1. , Department of Pharmaceutics, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharshtra, India
  2. Associate Professor, Department of Civil Engineering, PCCOER, Ravet, Pune, Maharshtra, India
  3. Associate Professor, Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharshtra, India
  4. Assistant Professor, Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharshtra, India

Abstract

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Polysaccharide-based hydrogels have showed great potential in medicine as materials for long-lasting, under control medication delivery systems. Natural polysaccharides include chitosan; alginate, agarose, and cellulose form these hydrogels. Among its many advantages are biocompatibility, biodegradability, and customising ability for various drug release rates. Reacting to pH, temperature, and ionic strength changes in the surroundings, polysaccharide-based hydrogels may swell. For usage requiring the release of therapeutic substances over an extended period of time, this makes them ideal. From tiny molecules to proteins and nucleic acids, these hydrogels may retain a great variety of medications. This guarantees that the medications reach the correct site of action, with the fewest adverse effects possible, therefore enhancing their efficacy. Usually, polysaccharide hydrogels are produced by physical or chemical crosslinkings. These crosslinks enable safe and delayed release of the medicine inside. Moreover, altering the molecules in polysaccharides may improve these hydrogels in respects like mechanical strength, growth rate, and breakdown speed. They may therefore be used for a range of medical needs. To improve these hydrogels’ medication retention and control of release, you may additionally use other nanomaterials such as nanoparticles or nanofibers. Although they offer great potential, creating polysaccharide-based hydrogels remains challenging. Making them again and often, increasing their scope, and securing official permission present challenges.

Keywords: Polysaccharide hydrogels, sustained drug release, drug delivery systems, biocompatibility, crosslinking methods, nanomaterials.

How to cite this article:
Ghorpade V.S., Sameer Sawarkar, Vijaykumar Javanjal, A.U. Rajurkar. Polysaccharide-Based Hydrogels for Sustained Drug Release in Pharmacology. Journal of Polymer and Composites. 2025; 13(04):-.
How to cite this URL:
Ghorpade V.S., Sameer Sawarkar, Vijaykumar Javanjal, A.U. Rajurkar. Polysaccharide-Based Hydrogels for Sustained Drug Release in Pharmacology. Journal of Polymer and Composites. 2025; 13(04):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 13
04
Received 20/03/2025
Accepted 19/05/2025
Published 31/05/2025
Publication Time 72 Days
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