Effect of Polymer Crosslinking on Drug Release Kinetics

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2025 | Volume : 13 | 03 | Page : –
    By

    Bhinge S. D.,

  • S. R. Satpute,

  • Mukesh Sharma,

  • Jambi Ratna Raja Kumar,

  1. , Department of Pharmaceutical Chemistry, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharshtra, India
  2. , Department of Chemical Engineering, Vishwakarma Institute of Technology, Pune, Maharshtra, India
  3. , Arya College of Pharmacy, Jaipur, Rajasthan, India
  4. , Department of Computer Engineering, Genba Sopanrao Moze College of Engineering, Balewadi, Pune, Maharshtra, India

Abstract

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In order to improve treatment effectiveness and minimise adverse effects, polymer-based drug delivery systems are often used to produce regulated and sustained drug release. Polymer crosslinking, which alters the structural, mechanical, and degrading characteristics of the polymer matrix, is one of the key elements affecting drug release kinetics. The porosity, swelling behaviour, and rate of degradation of the polymer are all impacted by the crosslinking process, which may be accomplished chemically, physically, photo-induced, or enzymatically. This study investigates how drug diffusion and release kinetics are affected by changes in crosslinking density. Networks of highly crosslinked polymers usually have less swelling and porosity, which slows drug transport and extends release. Lightly crosslinked polymers, on the other hand, facilitate quicker drug dispersion by enabling faster water penetration. Degradable crosslinked networks are appropriate for responsive drug delivery because they allow for regulated release by enzymatic or hydrolytic cleavage. By reacting to physiological circumstances, stimuli-responsive crosslinking such as pH-sensitive, thermo-responsive, or enzyme-degradable networks provides tailored drug release. These intelligent systems are very useful for site-specific medication administration, such in gastrointestinal-targeted formulations or cancer treatment. Applications of crosslinked polymers in ophthalmic, injectable, transdermal, and oral drug delivery systems are covered in the study. It emphasises how crucial it is to balance medication stability, release rate, and biocompatibility by optimizing crosslinking settings. Designing sophisticated drug delivery systems for targeted treatments and personalised medicine will be made possible by a deeper understanding of polymer crosslinking processes.

Keywords: Polymer Crosslinking, Hydrogel Networks, Diffusion Mechanism, Crosslinking Density, Biodegradable Polymers, Swelling Behavior, Ph-Responsive Polymers.

How to cite this article:
Bhinge S. D., S. R. Satpute, Mukesh Sharma, Jambi Ratna Raja Kumar. Effect of Polymer Crosslinking on Drug Release Kinetics. Journal of Polymer and Composites. 2025; 13(03):-.
How to cite this URL:
Bhinge S. D., S. R. Satpute, Mukesh Sharma, Jambi Ratna Raja Kumar. Effect of Polymer Crosslinking on Drug Release Kinetics. Journal of Polymer and Composites. 2025; 13(03):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 13
03
Received 20/03/2025
Accepted 27/03/2025
Published 31/05/2025
Publication Time 72 Days
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