Role and impact of Dietary Antioxidants on Aging and Lifespan: A Review

Year : 2025 | Volume : 15 | 02 | Page : –
    By

    Shabnam Khan,

  • Astha Priyadarshini,

  • Niyati Chakravarti,

  • Ritu Raj Singh,

  • Shabnam Khan,

  1. Assistant Professor, Department of Basic Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India
  2. Student, Department of Basic Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India
  3. Student, Department of Basic Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India
  4. Student, Department of Basic Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India
  5. Professor & Head, Department of Basic Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India

Abstract

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The effect of an antioxidant-rich diet on aging and lifespan has attracted significant scientific attention, primarily through the lens of the free radical theory of aging (FRTA). This theory suggests that oxidative stress caused by an accumulation of reactive oxygen species (ROS), accelerates aging and contributes to cellular damage. The accumulation of free radicals and the oxidative damage that is induced significantly contribute to the aging process. This imbalance plays a key role in the development of chronic and degenerative diseases such as cancer, autoimmune disorders, aging, cataracts, rheumatoid arthritis, cardiovascular disease, and neurodegenerative conditions. Antioxidants such as vitamins C and E, polyphenols, and flavonoids—commonly found in fruits, vegetables, and plant-based foods— are believed to mitigate oxidative damage, potentially enhancing health span and extending lifespan. While many studies report promising outcomes, including reduced oxidative damage and improved metabolic health, contradictory findings reveal negligible or even harmful effects in certain organisms. The complexity of aging involves multiple factors, including genome damage, telomere shortening, and mitochondrial dysfunction, emphasizing the need for a multifaceted approach that integrates biological, psychological and sociological perspectives. Research into dietary antioxidants highlights the value of a balanced diet rich in diverse food sources, which may offer protection against oxidative stress. Continued exploration is crucial to unravel the nuanced relationships between antioxidant intake, oxidative stress, and longevity, paving the way for potential dietary interventions to promote healthy aging and improve lifespan. Aging is a complex process involving multiple biological mechanisms, such as genome damage, telomere shortening, and mitochondrial dysfunction which require a holistic approach to fully understand. Although the role of antioxidants in preventing age-related diseases is well-documented, but their definitive impact on lifespan and aging remains unclear and requires further study.

Keywords: Antioxidants, Oxidative stress, Free radical, ROS, Aging, Lifespan

How to cite this article:
Shabnam Khan, Astha Priyadarshini, Niyati Chakravarti, Ritu Raj Singh, Shabnam Khan. Role and impact of Dietary Antioxidants on Aging and Lifespan: A Review. Research and Reviews : A Journal of Life Sciences. 2025; 15(02):-.
How to cite this URL:
Shabnam Khan, Astha Priyadarshini, Niyati Chakravarti, Ritu Raj Singh, Shabnam Khan. Role and impact of Dietary Antioxidants on Aging and Lifespan: A Review. Research and Reviews : A Journal of Life Sciences. 2025; 15(02):-. Available from: https://journals.stmjournals.com/rrjols/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 15
02
Received 24/05/2025
Accepted 29/05/2025
Published 29/05/2025
Publication Time 5 Days
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