Microsphere and Nanoparticle Drug Delivery Systems: Role of Polymers in Pharmacology

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Year : 2025 | Volume : 13 | 04 | Page : –
    By

    Patil M. B.,

  • Sameer Sawarkar,

  • Narayan Sapkal,

  • Vandana Sharma,

  1. Assistant Professor, Department of Pharmaceutics, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharashtra, India
  2. Associate Professor, Department of Civil Engineering, PCCOER, Ravet, Pune, Maharashtra, India
  3. Assistant Professor, Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharashtra, India
  4. Professor, Department of Pharmacy, Arya College of Pharmacy, Jaipur, Rajasthan, India

Abstract

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Microsphere and nanoscale drug delivery methods have changed the field of pharmacology by making treatment agents more bioavailable, more targeted, and easier to manage. These delivery systems, which are mostly made up of polymers, look like a good way to get around the problems that traditional drug formulations have, like not dissolving well, clearing quickly, and spreading in different places. Plastics are very important in the creation of these improved drug transport systems because they can be used in many ways and are biocompatible and biodegradable. Microspheres are bigger, usually between 1 and 1000 micrometres, and are used to hold drugs in place so that they can be released slowly over a long period of time. Nanoparticles, on the other hand, are only 1 to 100 nanometres wide, which means they can get through cellular walls more easily and target specific cells or tissues. Both techniques use polymers that may be altered to provide the ideal drug loading, regulated breakdown, and release to the appropriate site. Often utilised in these systems are natural biopolymers such gelatin, alginate, and chitosan. Other widely used synthetic polymers include poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG). Polymers not only provide pharmaceuticals with a home to reside but also affect how soon the medications are released, how they behave in the body, and how effectively they function as medicine in drug delivery systems. The employed polymer influences the safety, release profile, and interaction with the defence system of the system. Furthermore enhancing the surface of nanoparticles’ targeting accuracy are ligands or antibodies added to them. This guarantees that medications are administered precisely where they are required to be active, therefore lowering side effects. More efficient cancer treatments, gene therapies, and vaccinations are made feasible by recent advancements in polymeric microspheres and nanoparticles. These developments may entirely alter the way illnesses are controlled by making medications safer and more potent.

Keywords: Microspheres, Nanoparticles, Drug Delivery, Polymers, Biocompatibility

How to cite this article:
Patil M. B., Sameer Sawarkar, Narayan Sapkal, Vandana Sharma. Microsphere and Nanoparticle Drug Delivery Systems: Role of Polymers in Pharmacology. Journal of Polymer and Composites. 2025; 13(04):-.
How to cite this URL:
Patil M. B., Sameer Sawarkar, Narayan Sapkal, Vandana Sharma. Microsphere and Nanoparticle Drug Delivery Systems: Role of Polymers in Pharmacology. Journal of Polymer and Composites. 2025; 13(04):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 13
04
Received 20/03/2025
Accepted 06/05/2025
Published 29/05/2025
Publication Time 70 Days
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