3D-Printed Polymeric Drug Delivery Systems for Personalized Medicine

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2025 | Volume : 13 | 04 | Page : –
    By

    Patil A. A.,

  • G. N. Kotwal,

  • Pravin Ingle,

  • Mukesh Sharma,

  1. Associate Professor and Head, Department of Pharmacology, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharashtra, India
  2. Associate Professor, Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharashtra, India
  3. Assistant Professor, Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharashtra, India
  4. Associate Professor, Department of Pharmacy, Arya College of Pharmacy, Jaipur, Rajasthan, India

Abstract

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Personalized medicine has revolutionized healthcare by tailoring treatments to individual patient needs. Among the emerging technologies, 3D printing has demonstrated immense potential in fabricating polymeric drug delivery systems with precise control over drug release, dosage, and bioavailability. These systems offer customized therapeutic solutions, improving efficacy while reducing adverse effects. This paper provides an overview of 3D-printed polymeric drug delivery systems, discussing the types of polymers used, fabrication techniques, applications in personalized medicine, and challenges in clinical translation. Polymers such as poly(lactic acid) (PLA), polycaprolactone (PCL), polyvinyl alcohol (PVA), and hydrogels are widely utilized due to their biocompatibility and controlled drug release capabilities. Advanced 3D printing techniques, including fused deposition modeling (FDM), stereolithography (SLA), selective laser sintering (SLS), and inkjet printing, enable the creation of complex drug delivery structures with patient-specific attributes. These systems have shown promise in applications such as personalized oral dosage forms, transdermal patches, implantable drug reservoirs, and ophthalmic drug delivery. Despite their advantages, challenges remain in regulatory approval, material selection, scalability, and cost-effectiveness. Ensuring the safety, stability, and reproducibility of 3D-printed drug delivery systems requires rigorous research and validation. Future advancements in AI-driven formulation design, novel biodegradable polymers, and digital health integration are expected to enhance the feasibility of these systems in clinical settings. 3D-printed polymeric drug delivery systems represent a transformative approach to personalized medicine. With continued research and technological improvements, they have the potential to redefine drug administration, making treatments more effective and patient-centric.

Keywords: Personalized Medicine, Bioavailability Enhancement, Controlled Drug Release, Smart Polymers, Pharmaceutical Manufacturing, Patient-Specific, Nanostructured Polymers, Pharmacokinetics, Sustained Drug Release.

How to cite this article:
Patil A. A., G. N. Kotwal, Pravin Ingle, Mukesh Sharma. 3D-Printed Polymeric Drug Delivery Systems for Personalized Medicine. Journal of Polymer and Composites. 2025; 13(04):-.
How to cite this URL:
Patil A. A., G. N. Kotwal, Pravin Ingle, Mukesh Sharma. 3D-Printed Polymeric Drug Delivery Systems for Personalized Medicine. Journal of Polymer and Composites. 2025; 13(04):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 13
04
Received 20/03/2025
Accepted 22/05/2025
Published 29/05/2025
Publication Time 70 Days
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