
Soham Namdev Nikam,

Kunal Sharad Patil,

Sakshi Sachin Utpat,
- Student, Department of Pharmacy, Dr. DY Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India
- Student, Department of Pharmacy, Dr. DY Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India
- Student, Department of Pharmacy, Dr. DY Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India
Abstract
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The development of plant-based therapies for neurodegenerative diseases holds significant promise due to the therapeutic potential of natural compounds such as Laurus nobilis, Aronia melanocarpa, and celastrol. This review identifies critical literature gaps in the current research, including inconsistent extraction methods, lack of clinical trials, insufficient documentation of long-term effects, limited mechanistic insights, and poor bioavailability. Addressing these gaps through standardization, rigorous clinical trials, advanced delivery systems, and comprehensive ethnopharmacological documentation is essential. Moreover, the integration of plant-based agents with conventional treatments requires clear regulatory pathways and consideration of ethical issues. By bridging ethnopharmacological knowledge with modern scientific techniques, this research aims to enhance the clinical utility of plant-based compounds, paving the way for innovative, sustainable, and accessible treatments that improve patient outcomes in neurodegenerative disease management. The review underscores the need for holistic and multidisciplinary approaches to fully realize the potential of plant-based therapies in clinical settings.
Keywords: Neuro degenerative Diseases, Plant-Based Therapies, Antioxidants, Ethnopharmacology, Bioavailability.
Soham Namdev Nikam, Kunal Sharad Patil, Sakshi Sachin Utpat. Ethnopharmacological Insights: Uncovering Plant-Based Neuroprotective Treatments for Neurodegenerative Disorders. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2025; ():-.
Soham Namdev Nikam, Kunal Sharad Patil, Sakshi Sachin Utpat. Ethnopharmacological Insights: Uncovering Plant-Based Neuroprotective Treatments for Neurodegenerative Disorders. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2025; ():-. Available from: https://journals.stmjournals.com/rrjodfdp/article=2025/view=0
References
[1] Pilipović, K., Jurišić Grubešić, R., Dolenec, P., Kučić, N., Juretić, L., & Mršić-Peladić, J. (2023). Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol. Antioxidants, 12(3), 746. https://doi.org/10.3390/antiox12030746
[2] Ham, A., Shin, J., Oh, K.-B., Lee, S.-J., Nam, K.-W., Koo, U., Kim, K.-H., & Mar, W. (2011).
Neuroprotective Effect of the n-Hexane Extracts of Laurus nobilis L. in Models of Parkinson’s Disease. Biomol Ther, 19(1), 118-125.
[3] Pal R, Mukherjee S, Khan A, Nathani M, Maji S, Tandey R, Das S, Patra A, Mandal V. A critical appraisal on the involvement of plant-based extracts as neuroprotective agents (2012-2022): an effort to ease out decision-making process for researchers. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec;397(12):9367-9415. doi: 10.1007/s00210-024-03266-6.
[4] Dey, A., Nandy, S., Mukherjee, A. et al. Plant Natural Products as Neuroprotective Nutraceuticals: Preclinical and Clinical Studies and Future Implications. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 90, 929–943 (2020). https://doi.org/10.1007/s40011-020-01170-6
[5] Al-Snafi, A. E. (2021). Medicinal Plants with Neuroprotective Effects. GSC Biological and Pharmaceutical Sciences, 17(1), 213–231.
[6] Moise, G., Jîjie, A.-R., Moacă, E.-A., Predescu, I.-A., Dehelean, C. A., Hegheș, A., Vlad, D. C., Popescu, R., & Vlad, C. S. (2024). Plants’ Impact on the Human Brain—Exploring the Neuroprotective and Neurotoxic Potential of Plants. Pharmaceuticals, 17(10), 1339. https://doi.org/10.3390/ph17101339
[7] May, N., Shi, J., Clunas, H., Neri, J. L. d. S. A., Kelso, C., Morgan, J., Yu, Y., Charlton, K., & Weston-Green, K. (2024). Six Plant-Based Compounds Show Neuroprotective Potential. Neuroscience News. Available from: https://neurosciencenews.com/neuroprotection-plant-compounds-28157/
[8] Kumar, S., & Khanum, F. (2012). Neuroglia: Their Role in Neurodegenerative Diseases. Journal of Neuroimmune Pharmacology, 7(4), 434-446.
[9] Weston-Green, K., & Morgan, J. (2023). The Role of Plant- Based Antioxidants in Neurodegenerative Disease Management. Journal of Neurology and Neurosurgery, 84(2), 123-135.ment. Journal of Neurology and Neurosurgery, 84(2), 123-135.
[10] Shi, J., Clunas, H., Neri, J. L. d. S. A., Kelso, C., Morgan, J., Yu, Y., Charlton, K., & Weston-Green,
K. (2024). Neuroprotective Effects of Plant-Based Compounds: A Review. Food & Function, 15(3), 456-468.
[11] Lim, D. W., Lee, J.-E., Lee, C., & Kim, Y. T. (2024). Natural Products and Their Neuroprotective Effects in Degenerative Brain Diseases: A Comprehensive Review. International Journal of Molecular Sciences, 25(20), 11223.
[12] Moise, G., Jîjie, A.-R., Moacă, E.-A., Predescu, I.-A., Dehelean, C. A., Hegheș, A., Vlad, D. C., Popescu, R., & Vlad, C. S. (2024). Plants’ Impact on the Human Brain—Exploring the Neuroprotective and Neurotoxic Potential of Plants. Pharmaceuticals, 17(10), 1339.
[13] May, N., Shi, J., Clunas, H., Neri, J. L. d. S. A., Kelso, C., Morgan, J., Yu, Y., Charlton, K., & Weston-Green, K. (2024). Six Plant-Based Compounds Show Neuroprotective Potential. Neuroscience News.
[14] Weston-Green, K., & Morgan, J. (2023). The Role of Plant-Based Antioxidants in Neurodegenerative Disease Management. Journal of Neurology and Neurosurgery, 84(2), 123- 135.
[15] Shi, J., Clunas, H., Neri, J. L. d. S. A., Kelso, C., Morgan, J., Yu, Y., Charlton, K., & Weston-Green,
K. (2024). Neuroprotective Effects of Plant-Based Compounds: A Review. Food & Function, 15(3), 456-468.
[16] Lim DW, Lee JE, Lee C, Kim YT. Natural Products and Their Neuroprotective Effects in Degenerative Brain Diseases: A Comprehensive Review. Int J Mol Sci. 2024 Oct 18;25(20):11223. doi: 10.3390/ijms252011223.
[17] Moise G, Jîjie AR, Moacă EA, Predescu IA, Dehelean CA, Hegheș A, Vlad DC, Popescu R, Vlad CS. Plants’ Impact on the Human Brain-Exploring the Neuroprotective and Neurotoxic Potential of Plants. Pharmaceuticals (Basel). 2024 Oct 7;17(10):1339. doi: 10.3390/ph17101339.
[18] News N. Six Plant-Based Compounds Show Neuroprotective Potential – Neuroscience News [Internet]. Neuroscience News. 2024 [cited 2025 Jan 8]. Available from: https://neurosciencenews.com/neuroprotection-plant-compounds-28157/
[19] Pilipović, K., Jurišić Grubešić, R., Dolenec, P., Kučić, N., Juretić, L., & Mršić-Pelčić, J. (2023). Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol. Antioxidants, 12(3), 746. https://doi.org/10.3390/antiox12030746
[20] Rojas-García A, Fernández-Ochoa Á, Cádiz-Gurrea ML, Arráez-Román D, Segura-Carretero A. Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds. Nutrients. 2023 Jan 14;15(2):449. doi: 10.3390/nu15020449.
| Volume | |
| Received | 21/12/2024 |
| Accepted | 08/01/2025 |
| Published | 13/01/2025 |

