A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women

Year : 2024 | Volume : | : | Page : –
By
vector

Sarah Hasan Kadhum AL Huchaimi,

vector

Maysoon Khudair AL Hadrawi,

vector

Raja Jawad Mohmad,

  1. Lecturer, Department of Community Health, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, , Iraq
  2. Assistant Professor, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, , Iraq
  3. Lecturer, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, , Iraq

Abstract document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_abs_127268’);});Edit Abstract & Keyword

Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. It usually begins to appear during adolescence. The ovaries produce an abnormal amount of “androgens”, which are male sex hormones that are usually found in women in small quantities. Ovarian syndrome causes hormonal imbalances, irregular menstrual cycles, increased cysts in the ovaries, in addition to hair growth all over the body, acne, and pain in the pelvic area.  Irregular menstrual cycles, often accompanied by a lack of ovulation, can make it difficult to get pregnant and cause infertility. The cause of polycystic ovary syndrome is unknown, but women with a family history or those with type 2 diabetes are more susceptible to it. The risk factors for polycystic ovary syndrome are obesity and lack of movement, in addition to genetic factors and family medical history. Where PCOS is associated with insulin resistance and Obesity also Diabetes Mellitus type 2,  and Heart Disease, As well as recurrent miscarriage and various cancers, Cardiovascular Diseases (CVD), Chronic inflammation, and various cancers such as uterine and ovarian cancer. One of the most important pathological symptoms in women with polycystic ovary syndrome is the formation of several ovarian cysts containing immature eggs that grow at the same time, then their growth stops without reaching the appropriate size, and ovulation does not occur, and this is determined by ultrasound examination. The patient also suffers from infertility despite not taking contraindications for Pregnancy. Some of its symptoms are relieved by lifestyle changes, medications, and fertility treatments.so we designed this review to assess the relationship between polycystic ovary syndrome and some hormonal disturbances and Metabolic disturbances in an infected woman’s body.

Keywords: CVD, PCOS , Ovary, Metabolic

How to cite this article:
Sarah Hasan Kadhum AL Huchaimi, Maysoon Khudair AL Hadrawi, Raja Jawad Mohmad. A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women. Research & Reviews: A Journal of Microbiology & Virology. 2024; ():-.
How to cite this URL:
Sarah Hasan Kadhum AL Huchaimi, Maysoon Khudair AL Hadrawi, Raja Jawad Mohmad. A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women. Research & Reviews: A Journal of Microbiology & Virology. 2024; ():-. Available from: https://journals.stmjournals.com/rrjomv/article=2024/view=0

Full Text PDF

References
document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_ref_127268’);});Edit

  1. Karkera,, Agard, E., & Sankova, L. (2023). The clinical manifestations of polycystic ovary syndrome (PCOS) and the treatment options. European Journal of Biology and Medical Science Research, 11(1), 57-91.
  2. Jabeen, F., Khadija, S., & Daud, S. (2022). Prevalence of primary and secondary infertility. Saudi J Med, 7(1), 22-8.
  3. Joham, A. E., Norman, R. J., Stener-Victorin, E., Legro, R. S., Franks, S., Moran, L. J., … & Teede, H. J. (2022). Polycystic ovary syndrome. The lancet Diabetes & endocrinology, 10(9), 668-680.
  4. Adnan, A. N., & Hassan, A. S. U. (2023). Evaluation of Polycystic Ovary Syndrome (PCOS) Through Androstolone and Pituitary Hormones Lab Testing. Journal of Scientific Research in Medical and Biological Sciences, 4(3), 28-35.
  5. Dubey,, Reddy, S., Sharma, K., Johnson, S., Hardy, G., & Dwivedi, A. K. (2024). Polycystic Ovary Syndrome, Insulin Resistance, and Cardiovascular Disease. Current Cardiology Reports, 1-13.
  6. Siddiqui, S., Mateen, S., Ahmad, R., & Moin, S. (2022). A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS). Journal of assisted reproduction and genetics, 39(11), 2439-2473.
  7. Saharan,, Singh, V., & Singh, R. (2024). Genetic Testing in Polycystic Ovary Syndrome. In Genetic Testing in Reproductive Medicine(pp. 81-103). Singapore: Springer Nature Singapore.
  8. kaur, r., kaur, m., & suri, v. (2024). exploring long term health implications in four rotterdam phenotypes of polycystic ovary syndrome. anthropologie, 62(1).
  9. Aggarwal, S., & Pandey, K. (2023). Early identification of PCOS with commonly known diseases: Obesity, diabetes, high blood pressure and heart disease using machine learning techniques. Expert Systems with Applications, 217, 119532.
  10. Mayrhofer,, Hager, M., Walch, K., Ghobrial, S., Rogenhofer, N., Marculescu, R., … & Ott, J. (2020). The prevalence and impact of polycystic ovary syndrome in recurrent miscarriage: a retrospective cohort study and meta-analysis. Journal of clinical medicine, 9(9), 2700.
  11. Li, Z., Wang, Y. H., Wang, L. L., Hu, D. T., Teng, Y., Zhang, T. Y., … & Zou, Y. F. (2022). Polycystic ovary syndrome and the risk of endometrial, ovarian and breast cancer: An updated meta-analysis. Scottish Medical Journal, 67(3), 109-120.‏ ‏ ‏ ‏ ‏ ‏ ‏ ‏ ‏ ‏ ‏
  12. Stamou, I., Smith, K. T., Kim, H., Balasubramanian, R., Gray, K. J., & Udler, M. S. (2024). Polycystic Ovary Syndrome Physiologic Pathways Implicated Through Clustering of Genetic Loci. The Journal of Clinical Endocrinology & Metabolism, 109(4), 968-977.
  13. Ali, S., & Jabeen, S. (2024). Clinical features and presentation of polycystic ovary syndrome. In Polycystic Ovary Syndrome(pp. 56-60). Elsevier.
  14. Liu, J., Wu, Q., Hao, Y., Jiao, M., Wang, X., Jiang, S., & Han, L. (2021). Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Human Reproduction, 36(4), 1108-1119.
  15. Pea, J., Bryan, J., Wan, C., Oldfield, A. L., Ganga, K., Carter, F. E., … & Lujan, M. E. (2024). Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis. Human Reproduction Update, 30(1), 109-130.
  16. Chesnokov, M. S., Mamedova, A. R., Zhivotovsky, B., & Kopeina, G. S. (2024). A matter of new life and cell death: programmed cell death in the mammalian ovary. Journal of Biomedical Science, 31(1), 31.
  17. Ojo, A., Nwafor-Ezeh, P. I., Rotimi, D. E., Iyobhebhe, M., Ogunlakin, A. D., & Ojo, A. B. (2023). Apoptosis, inflammation, and oxidative stress in infertility: A mini review. Toxicology Reports.
  18. Zhang, K. H., Zhang, F. F., Zhang, Z. L., Fang, K. F., Sun, W. X., Kong, N., … & Zhao, S. M. (2024). Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation. Protein & Cell, pwad065.
  19. Kumar, S., Garg, K., Soni, A., & Dalal, M. (2024). A Comprehensive Review of Preclinical Models for Polycystic Ovary Syndrome. Current Drug Therapy, 19(4), 426-437.
  20. Maduka, A. U., & Okoye, C. A. (2024). Relationships Between Marital Stress, Depressive Symptoms, Psychache and Infertility Among Couples in Fertility Treatment, in Port Harcourt Nigeria. Social Science Research, 10(1).
  21. Rangi, S. K., Llarena, N. C., & Falcone, T. (2024). Surgical Treatment of Endometriomas: Impact on Ovarian Reserve. In Endometriosis-related Infertility: A Comprehensive Manual(pp. 131-148). Cham: Springer International Publishing.
  22. Malik, P. S., Sahoo, R. K., Sharawat, S., Singh, M., Garg, V., Bhatia, K., … & Kumar, L. (2023). Fertility and pregnancy in chronic myeloid leukemia: Real-world experience from an Indian tertiary care institution. Annals of Hematology, 102(8), 2087-2096.
  23. Athar, F., Karmani, M., & Templeman, N. M. (2024). Metabolic hormones are integral regulators of female reproductive health and function. Bioscience Reports, 44(1), BSR20231916.
  24. Lonardo, M. S., Cacciapuoti, N., Guida, B., Di Lorenzo, M., Chiurazzi, M., Damiano, S., & Menale, C. (2024). Hypothalamic-Ovarian axis and Adiposity Relationship in Polycystic Ovary Syndrome: Physiopathology and Therapeutic Options for the Management of Metabolic and Inflammatory Aspects. Current Obesity Reports, 1-20.
  25. Pratama, G., Wiweko, B., Asmarinah, Widyahening, I. S., Andraini, T., Bayuaji, H., & Hestiantoro, A. (2024). Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis. Scientific Reports, 14(1), 8229.
  26. Naz, S., & Amerjee, A. (2024). Management of subfertility in polycystic ovary syndrome. In Polycystic Ovary Syndrome(pp. 141-160). Elsevier.
  27. Aljaff, N. S. A. (2024). Studying the Effect of Sex Hormones and Their Relationship with Thyroid Hormones in Some Women Suffering from Secondary Infertility and Obesity in Baghdad Governorate. European Science Methodical Journal, 2(1), 16-26.
  28. Ostrovsky,, Ulman, M., Hemi, R., Lurie, S., Hazan, I., Ari, A. B., … & Zornitzki, T. (2024). Selective peripheral tissue response to high testosterone levels in an infertile woman without virilization signs. Endocrinology, Diabetes & Metabolism Case Reports, 2024(2).
  29. Sparić, R., Andjić, M., Rakić, A., Bjekić-Macut, J., Livadas, S., Kontić-Vučinić, O., … & Macut, D. (2024). Insulin-sensitizing agents for infertility treatment in woman with polycystic ovary syndrome: a narrative review of current clinical practice. Hormones, 23(1), 49-58.
  30. ‏‏Stener-Victorin,, Teede, H., Norman, R. J., Legro, R., Goodarzi, M. O., Dokras, A., … & Piltonen, T. T. (2024). Polycystic ovary syndrome. Nature Reviews Disease Primers, 10(1), 27.
  31. Sultana, R., Iqbal, M. J., Islam, R., & Biswash, P. K. (2024). Association between Polycystic Ovary Syndrome (PCOS) and Pregnancy Complications. Sch Int J Obstet Gynec, 7(1), 25-29.
  32. Rosato,, Sciarra, F., Minnetti, M., Degjoni, A., & Venneri, M. A. (2024). Clinical management of androgen excess and defect in women. Expert Review of Endocrinology & Metabolism, 19(1), 21-35.
  33. Schleh,, Ryan, B., Ahn, C., Ludzki, A., Van Pelt, D., Pitchford, L., … & Horowitz, J. (2024). Insulin-mediated suppression of fatty acid release predicts whole-body insulin resistance of glucose uptake and skeletal muscle insulin receptor activation. bioRxiv, 2024-02.
  34. Dewal, R. S., Yang, F. T., Baer, L. A., Vidal, P., Hernandez-Saavedra, D., Seculov, N. P., … & Stanford, K. I. (2024). Transplantation of committed pre-adipocytes from brown adipose tissue improves whole-body glucose homeostasis. Iscience, 27(2).
  35. Ramírez-Martínez, L., Palafox-Gómez, C., Porchia, L. M., & López-Bayghen, E. (2024). The Potential for Ketogenic Diets to Control Glucotoxicity, Hyperinsulinemia, and Insulin Resistance to Improve Fertility in Women with Polycystic Ovary Syndrome. Clinical and Experimental Obstetrics & Gynecology, 51(3), 57.‏‏
  36. ‏Pandey, M., & Niroula, K. (2024). Optimizing Nutrition for PCOS Management: A Comprehensive Guide.
  37. Tűű,, Nas, K., Török, M., & Várbíró, S. (2024). SHBG Levels Do Not Correlate with Insulin Levels in PCOS with Appropriate Fasting Insulin Sensitivity. Journal of Clinical Medicine, 13(3), 838.
  38. Misra,, Gada, J., Dhole, C., Varthakavi, P., & Bhagwat, N. (2024). Comparative Study of Insulin Sensitivity and Resistance and Their Correlation with Androgens in Lean and Obese Women with Polycystic Ovary Syndrome. Reproductive Sciences, 31(3), 754-763.
  39. ‏‏BÜYÜKYILMAZ, G., KOCA, S. B., ADIGÜZEL, K. T., BOYRAZ, M., & GURBUZ, F. (2024). The Role of the AMH, SHBG, Free Androgen Index and LH/FSH Ratio in the Diagnosis of Polycystic Ovary Syndrome in Adolescent. Türkiye Çocuk Hastalıkları Dergisi, 18(1), 34-40.
  40. Wongwananuruk, T., Kongcharoensukying, A., Pramyothin, P., Indhavivadhana, S., Tanmahasamut, P., Rattanachaiyanont, M., … & Chantrapanichkul, P. (2024). Body Fat Distribution in Thai Reproductive-Aged Polycystic Ovary Syndrome Women Compared with Non-Polycystic Ovary Syndrome Women. Clinical and Experimental Obstetrics & Gynecology, 51(2), 52.‏
  41. ‏ Silva, A., & Motta, A. (2024). Peroxisome proliferator-activated receptors and placental function in women with polycystic ovary syndrome. Reproduction, 167(5).
  42. ‏ ‏Ahima, R. S., & Park, H. K. (2024). Adipokines and metabolism. In Metabolic Syndrome: A Comprehensive Textbook(pp. 335-356). Cham: Springer International Publishing.
  43. ‏ Huang, H. Y. R., Badar, S., Said, M., Shah, S., Bharadwaj, H. R., Ramamoorthy, K., … & Bardhan, M. (2024). The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature. Molecular Biology Reports, 51(1), 1-22.
  44. Ali, S. M., ABDULHUSSEIN, I. F., & Kazom, S. N. (2024). Comparison of Letrozole vs Clomiphene Citrate for induction of ovulation in polycystic ovarian syndromeAn Iraqi study. Texas Journal of Medical Science, 30, 23-39.
  45. Suhail, H. A. (2024). Early Recurrent Pregnancy Loss. Journal for Research in Applied Sciences and Biotechnology, 3(1), 315-328.‏ A. (2024). Early Recurrent Pregnancy Loss. Journal for Research in Applied Sciences and Biotechnology, 3(1), 315-328.‏
  46. Hawraa Aide Khudir A, Shaimaa M A. Jawad. (2024). Evaluation of Relationship between GLP-1  and  GIP  Hormones and  Insulin  Resistance in  Patients with Type 2 Diabetes in AL-Najaf Government., Al-Harf Journal., Vol. 21., Issue. June 2024.
  47. Kiran, Z. (2024). Diagnostic criteria for polycystic ovary syndrome. In Polycystic Ovary Syndrome(pp. 61-74). Elsevier.
  48. ‏Wal, A., Dash, B., Jaiswal, V., Gupta, D., & Mishra, A. K. (2024). Role of inflammation, oxidative stress, and angiogenesis in polycystic ovary syndrome (PCOS): Current perspectives. Targeting Angiogenesis, Inflammation, and Oxidative Stress in Chronic Diseases, 459-485.
  49. Ansari, R. T., Syed, U., Riaz, M., Askari, S., & Anjum, S. (2024). Unveiling the spectrum: A cross-sectional exploration of hirsutism causes in women. Pakistan Journal of Medical Sciences, 40(4).
  50. Davranova, A. D., Ruziyev, S., Shomurodova, D., & Turakulova, D. (2024). POLYCYSTIC OVARY SYNDROME. Educational Research in Universal Sciences, 3(4 SPECIAL), 590-598.
  51. Farhana, A. A., & Shi, J. (2024). Systematic Review on the Various Clinical Features of Polycystic Ovary Syndrome (PCOS) Patients. J Life Sci, 10(2), 5159-5166.‏
  52. ‏ Gencoglu, S. (2024). Relationship between elevated serum decorin levels and acne vulgaris in women with PCOS. European Review for Medical & Pharmacological Sciences, 28(2).‏ ‏
  53. Sengupta, P., Dutta, S., & Hassan, M. F. (2024). Polycystic ovary syndrome (PCOS) and oxidative stress. Journal of Integrated Science and Technology, 12(3), 752-752.
  54. Liew, F. F., Dutta, S., & Sengupta, P. (2024). Fertility treatment-induced oxidative stress and reproductive disorders. Journal of Integrated Science and Technology, 12(3), 756-756.
  55. Goldstein, S., & Samuni, A. (2024). Chemistry of nitrogen dioxide and its biological implicatios. Redox Biochemistry and Chemistry, 100020.
  56. Yoshikawa, T., & You, F. (2024). Oxidative Stress and Bio-Regulation. International Journal of Molecular Sciences, 25(6), 3360.
  57. Hussain, S., Rasul, A., Hussain, G., Rasheed, M., Manan, M., Riaz, K., … & Adem, S. (2023). Physiological Significance of Oxidative Stress and Anti-oxidative System. In The Role of Natural Antioxidants in Brain Disorders(pp. 49-69). Cham: Springer International Publishing.
  58. Cavalcanti, R. N., Pimentel, T. C., Esmerino, E. A., de Freitas, M. Q., Verruck, S., Silva, M. C., & da Cruz, A. G. (2023). Cold Plasma. Novel Technologies in Food Science, 109-169.
  59. Ahmad, R., & Surguchov, A. (2024). Reactive Oxygen Species: Advances and Developments. BoD–Books on Demand.
  60. Bhattacharya, K., Dey, R., Sen, D., Paul, N., Basak, A. K., Purkait, M. P., … & Syamal, A. K. (2024). Polycystic ovary syndrome and its management: In view of oxidative stress. Biomolecular Concepts, 15(1), 20220038.
  61. Bhattacharya, K., Dey, R., Sen, D., Paul, N., Basak, A. K., Purkait, M. P., … & Syamal, A. K. (2024). Polycystic ovary syndrome and its management: In view of oxidative stress. Biomolecular Concepts, 15(1), 20220038.
  62. ‏Cheng, W., Tan, L., Yu, S., Song, J., Li, Z., Peng, X., … & Yang, X. (2024). Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification. International Immunopharmacology, 131, 111820.‏

Ahead of Print Subscription Review Article
Volume
Received 06/11/2024
Accepted 30/11/2024
Published 11/12/2024